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    ANTIBODY AND PROTEIN THERAPUTIC FORMULATIONS AND USES THEREOF
    1.
    发明申请
    ANTIBODY AND PROTEIN THERAPUTIC FORMULATIONS AND USES THEREOF 审中-公开

    公开(公告)号：US20200031917A1

    公开(公告)日：2020-01-30

    申请号：US16337103

    申请日：2017-09-25

    Applicant: Edward R. Kraft ,  Steven Andrew GIANNOS ,  Bernard Godley

    Inventor： Edward R. Kraft ,  Steven Andrew GIANNOS ,  Bernard Godley

    IPC: C07K16/22 ,  A61K38/06 ,  A61K38/17 ,  A61K47/18 ,  A61K47/26 ,  A61K47/10

    Abstract: The present disclosure provides pharmaceutical compositions for monoclonal antibodies, antibody-related products, therapeutic proteins, peptides and other biopharmaceuticals. The compositions provide initial and long term stability of the biopharmaceutical agent, rendering them suitable for parenteral, pulmonary, transdermal, topical, intradermal, intrascleral, intracorneal, ocular and other forms of delivery. The compositions and methods lead to higher yields in dilute solutions and reduce unwanted aggregation of the biopharmaceutical agent. The compositions and methods also allow for disaggregation of previously aggregated proteins and protection from aggregation upon dilution. Additionally, provided are non-aggregating antibody reagents for analytical immunoassays including ELISA methods. The invention provides compositions and methods for topical, enteral, parenteral, pulmonary and other forms of delivery of biologically active substances. Also provided is the transscleral, transcorneal or transocular delivery of high molecular weight, biologically active substances to a patient, with or without pulsed infrared (IR) light. The compositions may also incorporate nanotechnologies to formulate the active substances.

    Photokinetic delivery of biologically active substances using pulsed incoherent light
    4.
    发明授权
    Photokinetic delivery of biologically active substances using pulsed incoherent light 有权
    使用脉冲非相干光进行生物活性物质的光动力输送

    公开(公告)号：US07458982B2

    公开(公告)日：2008-12-02

    申请号：US10679112

    申请日：2003-10-03

    Applicant: Edward R. Kraft ,  Gabriela Kulp

    Inventor： Edward R. Kraft ,  Gabriela Kulp

    IPC: A61N5/00 ,  A61K38/00

    CPC classification number: A61K47/02 ,  A61K9/0014 ,  A61K41/0042 ,  A61K45/06

    Abstract: The invention relates generally to transdermal and transmembrane delivery of biologically active substances through the skin, sub-dermal tissues, blood vessels and cellular membranes without causing damage to the cellular surface, tissue or membrane. The invention provides compositions and methods for enhanced transdermal and transmembrane delivery of biologically active substances using pulsed incoherent light. The invention further provides a device for the application of the pulsed incoherent light to cellular surfaces and membranes using those compositions and methods.

    Abstract translation: 本发明一般涉及通过皮肤，皮下组织，血管和细胞膜的生物活性物质的透皮和跨膜递送，而不会损伤细胞表面，组织或膜。 本发明提供了使用脉冲非相干光增强生物活性物质的透皮和跨膜递送的组合物和方法。 本发明还提供了使用这些组合物和方法将脉冲非相干光应用于细胞表面和膜的装置。

    PULSE DRUG NEBULIZATION SYSTEM, FORMULATIONS THEREFORE, AND METHODS OF USE
    6.
    发明申请
    PULSE DRUG NEBULIZATION SYSTEM, FORMULATIONS THEREFORE, AND METHODS OF USE 审中-公开
    脉冲药物释放系统，其制剂和使用方法

    公开(公告)号：US20150034077A1

    公开(公告)日：2015-02-05

    申请号：US14330200

    申请日：2014-07-14

    Applicant: Edward R. KRAFT ,  Perenlai Enkhbaatar ,  Daniel S. Traber ,  Gabriela A. Kulp

    Inventor： Edward R. KRAFT ,  Perenlai Enkhbaatar ,  Daniel S. Traber ,  Gabriela A. Kulp

    IPC: A61M15/00 ,  A61M15/08 ,  A61M11/04

    CPC classification number: A61M15/002 ,  A61M11/04 ,  A61M11/06 ,  A61M15/00 ,  A61M15/0021 ,  A61M15/009 ,  A61M15/08 ,  A61M16/06 ,  A61M2202/0007 ,  B05B7/066 ,  B05B7/0876 ,  B05B7/0892

    Abstract: Liquid nebulizer apparatus, systems, and formulation compositions, as well as systems for the nebulized, aerosol delivery of such compositions, for the administration and insufflation of medicinal aerosols into the pulmonary system of a mammal are described. The nebulizing apparatus and system can effectively aerosolize a variety of viscosities of medicinal liquid drug carriers, including those made up of oil, water, or emulsions of oil and water. Drugs dissolved or suspended in the compositions and formulations described and adapted for use herein are not damaged or denatured by the nebulization process when the nebulizer described is used. Further, the nebulization system itself can be adapted for use with both mechanically assisted pulmonary ventilation systems as well as hand-held inhalers and nose/mouth face masks for use in pulmonary drug delivery.

    Abstract translation: 描述了液体雾化器装置，系统和制剂组合物，以及用于雾化，气溶胶递送这种组合物的系统，用于将药物气溶胶施用和吹入哺乳动物的肺系统。 雾化装置和系统可以有效地雾化药液载体的各种粘度，包括由油，水或油和水的乳液组成的药物载体。 溶解或悬浮在本文所述和适用的组合物和制剂中的药物在使用所述雾化器时不会被雾化过程损坏或变性。 此外，雾化系统本身可以适用于机械辅助肺通气系统以及用于肺部药物递送的手持式吸入器和鼻/口罩。

    PULSE DRUG NEBULIZATION SYSTEM, FORMULATIONS THEREFORE, AND METHODS OF USE
    8.
    发明申请
    PULSE DRUG NEBULIZATION SYSTEM, FORMULATIONS THEREFORE, AND METHODS OF USE 有权
    脉冲药物释放系统，其制剂和使用方法

    公开(公告)号：US20120174915A1

    公开(公告)日：2012-07-12

    申请号：US13423044

    申请日：2012-03-16

    Applicant: Edward R. Kraft ,  Perenlai Enkhbaatar ,  Daniel L. Traber ,  Gabriela A. Kulp

    Inventor： Edward R. Kraft ,  Perenlai Enkhbaatar ,  Daniel L. Traber ,  Gabriela A. Kulp

    IPC: A61M11/00

    CPC classification number: A61M15/002 ,  A61M11/04 ,  A61M11/06 ,  A61M15/00 ,  A61M15/0021 ,  A61M15/009 ,  A61M15/08 ,  A61M16/06 ,  A61M2202/0007 ,  B05B7/066 ,  B05B7/0876 ,  B05B7/0892

    Abstract: Liquid nebulizer apparatus, systems, and formulation compositions, as well as systems for the nebulized, aerosol delivery of such compositions, for the administration and insufflation of medicinal aerosols into the pulmonary system of a mammal are described. The nebulizing apparatus and system can effectively aerosolize a variety of viscosities of medicinal liquid drug carriers, including those made up of oil, water, or emulsions of oil and water. Drugs dissolved or suspended in the compositions and formulations described and adapted for use herein are not damaged or denatured by the nebulization process when the nebulizer described is used. Further, the nebulization system itself can be adapted for use with both mechanically assisted pulmonary ventilation systems as well as hand-held inhalers and nose/mouth face masks for use in pulmonary drug delivery.

    Abstract translation: 描述了液体雾化器装置，系统和制剂组合物，以及用于雾化，气溶胶递送这种组合物的系统，用于将药物气溶胶施用和吹入哺乳动物的肺系统。 雾化装置和系统可以有效地雾化药液载体的各种粘度，包括由油，水或油和水的乳液组成的药物载体。 溶解或悬浮在本文所述和适用的组合物和制剂中的药物在使用所述雾化器时不会被雾化过程损坏或变性。 此外，雾化系统本身可以适用于机械辅助肺通气系统以及用于肺部药物递送的手持式吸入器和鼻/口罩。

    Pulse drug nebulization system, formulations therefore, and methods of use
    10.
    发明授权
    Pulse drug nebulization system, formulations therefore, and methods of use 有权
    因此脉冲药物雾化系统，配方及使用方法

    公开(公告)号：US08776786B2

    公开(公告)日：2014-07-15

    申请号：US13423044

    申请日：2012-03-16

    Applicant: Edward R Kraft ,  Perenlai Enkhbaatar ,  Daniel S Traber ,  Gabriela A. Kulp

    Inventor： Edward R Kraft ,  Perenlai Enkhbaatar ,  Daniel S Traber ,  Gabriela A. Kulp

    IPC: A61M11/00 ,  A61M15/00 ,  A61M16/10

    CPC classification number: A61M15/002 ,  A61M11/04 ,  A61M11/06 ,  A61M15/00 ,  A61M15/0021 ,  A61M15/009 ,  A61M15/08 ,  A61M16/06 ,  A61M2202/0007 ,  B05B7/066 ,  B05B7/0876 ,  B05B7/0892

    Abstract: Liquid nebulizer apparatus, systems, and formulation compositions, as well as systems for the nebulized, aerosol delivery of such compositions, for the administration and insufflation of medicinal aerosols into the pulmonary system of a mammal are described. The nebulizing apparatus and system can effectively aerosolize a variety of viscosities of medicinal liquid drug carriers, including those made up of oil, water, or emulsions of oil and water. Drugs dissolved or suspended in the compositions and formulations described and adapted for use herein are not damaged or denatured by the nebulization process when the nebulizer described is used. Further, the nebulization system itself can be adapted for use with both mechanically assisted pulmonary ventilation systems as well as hand-held inhalers and nose/mouth face masks for use in pulmonary drug delivery.

    Abstract translation: 描述了液体雾化器装置，系统和制剂组合物，以及用于雾化，气溶胶递送这种组合物的系统，用于将药物气溶胶施用和吹入哺乳动物的肺系统。 雾化装置和系统可以有效地雾化药液载体的各种粘度，包括由油，水或油和水的乳液组成的药物载体。 溶解或悬浮在本文所述和适用的组合物和制剂中的药物在使用所述雾化器时不会被雾化过程损坏或变性。 此外，雾化系统本身可以适用于机械辅助肺通气系统以及用于肺部药物递送的手持式吸入器和鼻/口罩。

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