公开(公告)号：US20120276014A1

公开(公告)日：2012-11-01

申请号：US13318097

申请日：2010-04-29

Applicant: Bruce A. Molitoris ,  Exing Wang ,  Ruben M. Sandoval

Inventor： Bruce A. Molitoris ,  Exing Wang ,  Ruben M. Sandoval

IPC: A61K49/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N33/48 ,  G06F19/00

CPC classification number: A61K49/0054 ,  A61K49/0043

Abstract: The present invention is related generally to measurement of body fluid volumes in an animal subject. The body fluid volumes of interest include extracellular fluid volume (ECFV), total vascular plasma volume (TVPV) and interstitial fluid volume (IFV). The methods are especially beneficial for subjects suffering from renal failure and particularly those undergoing renal dialysis. ECFV can be measured by administering a first molecule which is non-metabolized and permeable to vessel walls of the vascular system wherein the first molecule is distributed within the total vascular space as well as the interstitial space. TVPV can be measured by administering a second molecule which is non-metabolized and impermeable to vessel walls of the vascular system wherein the second molecule is distributed within only the vascular space. IFV can then be calculated using the equation IFV=ECFV−TVPV.

Abstract translation: 本发明一般涉及动物受试者体液体积的测量。 感兴趣的体液体积包括细胞外液体积（ECFV），总血管血浆体积（TVPV）和间质液体体积（IFV）。 这些方法对于患有肾功能衰竭的受试者尤其是肾透析患者特别有益。 可以通过施用第一分子来测量ECFV，所述第一分子是血管系统的血管壁的非代谢和可渗透的，其中第一分子分布在总血管空间以及间质空间内。 TVPV可以通过施用第二分子来测量，所述第二分子是非代谢的并且不渗透血管系统的血管壁，其中第二分子仅分布在血管空间内。 然后可以使用IFV = ECFV-TVPV等式计算IFV。

公开(公告)号：US08591865B2

公开(公告)日：2013-11-26

申请号：US12946471

申请日：2010-11-15

Applicant: Exing Wang ,  Daniel Meier ,  Robert Bunch ,  Bruce Molitoris ,  Ruben Sandoval ,  Matthew Rubin ,  Erinn Sheridan

Inventor： Exing Wang ,  Daniel Meier ,  Robert Bunch ,  Bruce Molitoris ,  Ruben Sandoval ,  Matthew Rubin ,  Erinn Sheridan

IPC: A61B10/00 ,  A61B5/00 ,  A61B8/00

CPC classification number: A61K49/0043 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/201 ,  A61B5/412 ,  A61K49/0017 ,  A61K49/0054

Abstract: A method for measuring a glomerular filtration rate of a mammalian subject comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the vascular system of the mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the glomerular filtration rate.

Abstract translation: 用于测量哺乳动物受试者的肾小球滤过率的方法包括报告物和标记物荧光分子的来源。 将荧光分子引入哺乳动物受试者的血管系统。 在一段时间内，测量报告物和标记荧光分子的强度。 计算一个比例以确定肾小球滤过率。

公开(公告)号：US20110201940A1

公开(公告)日：2011-08-18

申请号：US12946471

申请日：2010-11-15

Applicant: Exing Wang ,  Daniel Meier ,  Robert Bunch ,  Bruce Molitoris ,  Ruben Sandoval ,  Matthew Rubin ,  Erinn Sheridan

Inventor： Exing Wang ,  Daniel Meier ,  Robert Bunch ,  Bruce Molitoris ,  Ruben Sandoval ,  Matthew Rubin ,  Erinn Sheridan

IPC: A61B6/00 ,  A61K49/00 ,  A61P43/00

CPC classification number: A61K49/0043 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/201 ,  A61B5/412 ,  A61K49/0017 ,  A61K49/0054

Abstract: A method for measuring a glomerular filtration rate of a mammalian subject comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the vascular system of the mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the glomerular filtration rate.

Abstract translation: 用于测量哺乳动物受试者的肾小球滤过率的方法包括报告物和标记物荧光分子的来源。 将荧光分子引入哺乳动物受试者的血管系统。 在一段时间内，测量报告物和标记荧光分子的强度。 计算一个比例以确定肾小球滤过率。

公开(公告)号：US20090285761A1

公开(公告)日：2009-11-19

申请号：US12425827

申请日：2009-04-17

Applicant: Exing Wang ,  Daniel Meier ,  Robert Bunch ,  Bruce Molitoris ,  Ruben Sandoval ,  Matthew Rubin

Inventor： Exing Wang ,  Daniel Meier ,  Robert Bunch ,  Bruce Molitoris ,  Ruben Sandoval ,  Matthew Rubin

IPC: A61K49/12 ,  A61K49/00 ,  A61P43/00

CPC classification number: A61B5/201 ,  A61B1/00154 ,  A61B1/00165 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/412 ,  A61B5/6852 ,  A61K49/0017 ,  A61M5/007

Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.

Abstract translation: 用于测量哺乳动物肾脏中肾小球滤过率的方法包括报告物和标记物荧光分子的来源。 将荧光分子引入哺乳动物受试者的血液中。 在一段时间内，测量报告物和标记荧光分子的强度。 计算比例以确定受试者的肾脏的健康状况。 该方法基于标记分子的荧光相对于报告分子的荧光测量血浆分布的体积。