公开(公告)号：US11648312B2

公开(公告)日：2023-05-16

申请号：US16955457

申请日：2018-12-21

Applicant: Freedom Waves S.R.L ,  Pierangela Giustetto

Inventor： Pierangela Giustetto ,  Daniele Faletto

IPC: A61K41/00 ,  G16H20/17 ,  A61N7/00 ,  B06B1/02 ,  G16H40/67 ,  G16H70/60 ,  G16H50/50 ,  G16H50/70 ,  G16H70/40 ,  G16H40/40 ,  A61P35/00 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/704

CPC classification number: A61K41/0047 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/704 ,  A61N7/00 ,  A61P35/00 ,  B06B1/0215 ,  G16H20/17 ,  G16H40/40 ,  G16H40/67 ,  G16H50/50 ,  G16H50/70 ,  G16H70/40 ,  G16H70/60 ,  A61N2007/0004 ,  A61N2007/0078 ,  B06B2201/55 ,  B06B2201/76

Abstract: System for inducing sonoporation of a drug into cancer cells in a tumor and method thereof, the system comprising a generator configured to provide electrical energy at an ultrasound frequency; an ultrasound probe electrically connected to the generator and configured to convert the electrical energy into low intensity pulsed ultrasonic waves defined by operation parameters, said operation parameters comprising the frequency, the duty cycle, the operation time of the ultrasonic waves; an input device enabling an operator to enter configuration data comprising: type of tumor, type of drug, localization of secondary tumor, anthropometric measurements and grade of tumor, and a processor configured to determine the values of the operation parameters on the basis of the entered configuration data and control the generator and the ultrasound probe to operate according to said determined values, wherein the value of the frequency is determined on the basis of the type of tumor, the localization of the tumor, the grade of tumor and the anthropometric measurements, the value of the duty cycle is determined on the basis of the drug, the type of tumor and the grade of the tumor, and the value of said operation time being determined on the basis of at least the type of tumor and the type of drug.

公开(公告)号：US20240382595A1

公开(公告)日：2024-11-21

申请号：US18308247

申请日：2023-04-27

Applicant: Peirangela Giustetto ,  Freedom Waves S.R.L.

Inventor： Pierangela Giustetto ,  Daniele Faletto

IPC: A61K41/00 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/704 ,  A61N7/00 ,  A61P35/00 ,  B06B1/02 ,  G16H20/17 ,  G16H40/40 ,  G16H40/67 ,  G16H50/50 ,  G16H50/70 ,  G16H70/40 ,  G16H70/60

Abstract: A method for controlling ultrasonic waves to induced sonoporation of a drug into cancer cells in a tumor. The method may include accessing configuration data that may include a type of the tumor and a type of drug, and determining values of operational parameters that may be based on the configuration data to define determined values. The operational parameters may include frequency value and duty cycle value. The method may also include determining frequency value which may be based on the type of tumor that may define a determined frequency value, and determining the duty cycle value which may be based on the type of drug and the type of tumor that may define a determined duty cycle value.

公开(公告)号：US20210069332A1

公开(公告)日：2021-03-11

申请号：US16955457

申请日：2018-12-21

Applicant: Pierangela GIUSTETTO ,  Freedom Waves S.R.L.

Inventor： Pierangela GIUSTETTO ,  Daniele FALETTO

IPC: A61K41/00 ,  A61K31/337 ,  A61K31/704 ,  A61K31/4745 ,  A61K31/513 ,  A61P35/00 ,  A61N7/00 ,  G16H20/17 ,  G16H50/70 ,  G16H40/67 ,  G16H40/40 ,  G16H70/40 ,  G16H70/60 ,  G16H50/50 ,  B06B1/02

Abstract: System for inducing sonoporation of a drug into cancer cells in a tumor and method thereof, the system comprising a generator configured to provide electrical energy at an ultrasound frequency; an ultrasound probe electrically connected to the generator and configured to convert the electrical energy into low intensity pulsed ultrasonic waves defined by operation parameters, said operation parameters comprising the frequency, the duty cycle, the operation time of the ultrasonic waves; an input device enabling an operator to enter configuration data comprising: type of tumor, type of drug, localization of secondary tumor, anthropometric measurements and grade of tumor, and a processor configured to determine the values of the operation parameters on the basis of the entered configuration data and control the generator and the ultrasound probe to operate according to said determined values, wherein the value of the frequency is determined on the basis of the type of tumor, the localization of the tumor, the grade of tumor and the anthropometric measurements, the value of the duty cycle is determined on the basis of the drug, the type of tumor and the grade of the tumor, and the value of said operation time being determined on the basis of at least the type of tumor and the type of drug.