公开(公告)号：US20120010601A1

公开(公告)日：2012-01-12

申请号：US13149068

申请日：2011-05-31

Applicant: Scott D. Simon ,  George Ding ,  Joseph Cheng

Inventor： Scott D. Simon ,  George Ding ,  Joseph Cheng

IPC: A61B17/00 ,  A61P35/04 ,  A61K51/06

CPC classification number: A61K41/0085 ,  A61B17/7097 ,  A61B2017/005

Abstract: A method of treating diseased tissue in a patient, the diseased tissue being proximate a hardened previously implanted bone cement including relatively high atomic number elements in a patient. The method includes generating a photon beam and directing the generated photon beam into the patient in a direction such that at least a portion of the photon beam impinges on the hardened bone cement and generates Compton interaction knock-out electrons from the high atomic number elements included in the hardened bone cement as a result of interaction of the at least a portion of the photon beam with the bone cement, wherein the direction of the photon beam is such that the at least a portion of the photon beam impinges on the hardened bone cement so that at least some of the Compton interaction knock-out electrons impinge upon the diseased tissue.

Abstract translation: 一种治疗患者中的患病组织的方法，所述患病组织接近硬化的先前植入的骨水泥，其包括患者体内相对较高的原子数元素。 该方法包括产生光子束并将所产生的光子束以使得至少一部分光子束撞击硬化的骨粘固剂的方向引导到患者体内，并从包括的高原子数元素产生康普顿相互作用的敲除电子 在硬化的骨水泥中，由于光子束的至少一部分与骨粘固剂相互作用，其中光子束的方向使得至少一部分光子束撞击硬化的骨水泥 使得至少一些康普顿相互作用的敲除电子撞击患病组织。

公开(公告)号：US20120041685A1

公开(公告)日：2012-02-16

申请号：US13181908

申请日：2011-07-13

Applicant: George Ding ,  Jason Pawlowski

Inventor： George Ding ,  Jason Pawlowski

IPC: G06F19/00

CPC classification number: A61B6/032 ,  A61B6/501 ,  A61B6/542 ,  A61N5/1031

Abstract: Systems and methods for accurately calculating radiation doses in biological tissues exposed to a radiation source are provided. In the systems and methods first, a radiation dose is computed to geometry of water equivalent medium of the biological tissues, expressed in computed tomography (CT) volumetric images. A Medium-Dependent-Correction factor that is a function of an effective bone depth matrix and the incident x-ray beam is obtained and tabulated. Using patient material and density data derived from CT images, the effective bone thickness can be calculated from a specific x-ray source. Finally, a Medium-Dependent-Correction factor that is a function of an effective bone depth matrix is used to accurately determine the radiation dose distributions to biological tissues.

Abstract translation: 提供了准确计算暴露于辐射源的生物组织中辐射剂量的系统和方法。 在系统和方法中，首先计算辐射剂量，以计算机断层摄影（CT）体积图像表示的生物组织的水当量介质的几何形状。 中等依赖性修正因子是有效骨深度矩阵和入射X射线束的函数，并列表。 使用从CT图像获得的患者材料和密度数据，可以从特定的X射线源计算有效的骨厚度。 最后，使用作为有效骨深度矩阵的函数的中等依赖性修正因子来准确地确定对生物组织的辐射剂量分布。