公开(公告)号：US07173446B2

公开(公告)日：2007-02-06

申请号：US10875874

申请日：2004-06-24

Applicant: Arthur R. Isakharov ,  Isaac Chang ,  Ai Ssa Chai ,  Timothy M. Swettlen

Inventor： Arthur R. Isakharov ,  Isaac Chang ,  Ai Ssa Chai ,  Timothy M. Swettlen

IPC: G01R31/26

CPC classification number: G01R31/31924 ,  G01R31/2841

Abstract: According to one embodiment a system is disclosed. The system includes a tester having a power supply, an integrated circuit device under test (DUT) and a transient compressor (TC) coupled between the tester and the power supply to stabilize power delivered to the DUT by injecting current into the path between the power supply and the DUT.

Abstract translation: 根据一个实施例，公开了一种系统。 该系统包括具有电源的测试器，被测试的集成电路器件（DUT）和耦合在测试器和电源之间的瞬态压缩器（TC），用于通过将电流注入到功率之间的路径中来稳定输送到DUT的功率 供应和DUT。

公开(公告)号：US20050285613A1

公开(公告)日：2005-12-29

申请号：US10875874

申请日：2004-06-24

Applicant: Arthur Isakharov ,  Isaac Chang ,  Ai Ssa Chai ,  Timothy Swettlen

Inventor： Arthur Isakharov ,  Isaac Chang ,  Ai Ssa Chai ,  Timothy Swettlen

IPC: G01R31/26 ,  G01R31/28 ,  G01R31/319

CPC classification number: G01R31/31924 ,  G01R31/2841

Abstract: According to one embodiment a system is disclosed. The system includes a tester having a power supply, an integrated circuit device under test (DUT) and a transient compressor (TC) coupled between the tester and the power supply to stabilize power delivered to the DUT by injecting current into the path between the power supply and the DUT.

Abstract translation: 根据一个实施例，公开了一种系统。 该系统包括具有电源的测试器，被测试的集成电路器件（DUT）和耦合在测试器和电源之间的瞬态压缩器（TC），用于通过将电流注入到功率之间的路径中来稳定输送到DUT的功率 供应和DUT。

公开(公告)号：US5562721A

公开(公告)日：1996-10-08

申请号：US438326

申请日：1995-05-10

Applicant: Francis E. Marchlinski ,  David S Schwartzman ,  Mark S. Mirotznik ,  Kenneth R. Foster ,  Charles D. Gottlieb ,  Isaac Chang

Inventor： Francis E. Marchlinski ,  David S Schwartzman ,  Mark S. Mirotznik ,  Kenneth R. Foster ,  Charles D. Gottlieb ,  Isaac Chang

IPC: A61B18/14 ,  A61N1/05 ,  A61N1/40 ,  A61B17/39

CPC classification number: A61N1/025 ,  A61B18/1492 ,  A61N1/05 ,  A61N1/056 ,  A61N1/40 ,  A61B18/1402 ,  A61B2018/00702 ,  A61B2018/00875 ,  A61B2018/126 ,  A61B2034/2051 ,  A61B2090/065

Abstract: A method of locating infarcted myocardial tissue in a beating heart includes the step of inserting an impedance measuring tip of a catheter into the chamber of the beating heart, particularly the left or right ventricle, and measuring the impedance of the endocardium at various locations within the chamber of the beating heart. The values measured are compared to impedance values with a predetermined range of values to identify an infarcted area of myocardium and distinguish such area from normal myocardium. The measurements are also compared to a range of values for an infarction border zone. In accordance with the invention, the infarction border zone may be located. The infarction border zone is a significant source of arrhythmia, and particularly of ventricular tachycardia. Further, in accordance with the methods of the present invention, the risk of arrhythmia in a beating heart may be substantially reduced or eliminated by ablating endocardium within the infarction border zone utilizing the same catheter tip. Impedance measurements may also be utilized to assess the adequacy of the electrode-tissue contact, particularly in a fluid filled body organ or cavity. Further, the effectiveness of the ablation of the tissue may be determined by determining the degree of heating of the tissue by measuring the change in impedance in the area of ablation.

Abstract translation: 在搏动心脏中定位梗死心肌组织的方法包括将导管的阻抗测量尖端插入跳动心脏的腔室中，特别是左心室或右心室的步骤，以及测量内心内的不同位置处的心内膜的阻抗 心跳的房间。 将所测量的值与具有预定范围值的阻抗值进行比较，以鉴定心肌的梗塞面积并将该区域与正常心肌区分开。 也将测量结果与梗塞边界区域的范围进行比较。 根据本发明，可以设置梗塞边界区域。 梗死边界区是心律失常的重要来源，特别是室性心动过速。 此外，根据本发明的方法，通过利用相同的导管尖端在梗塞边界区域中消融心内膜，可以显着减少或消除跳动心脏中的心律不齐的风险。 还可以使用阻抗测量来评估电极 - 组织接触的充分性，特别是在流体填充的身体器官或空腔中。 此外，可以通过测量消融区域中的阻抗变化来确定组织的加热程度来确定组织消融的有效性。

公开(公告)号：US5447529A

公开(公告)日：1995-09-05

申请号：US188514

申请日：1994-01-28

Applicant: Francis E. Marchlinski ,  David S. Schwartzman ,  Mark S. Mirotznik ,  Kenneth R. Foster ,  Charles D. Gottleb ,  Isaac Chang

Inventor： Francis E. Marchlinski ,  David S. Schwartzman ,  Mark S. Mirotznik ,  Kenneth R. Foster ,  Charles D. Gottleb ,  Isaac Chang

IPC: A61B18/14 ,  A61N1/05 ,  A61N1/40 ,  A61B17/39

CPC classification number: A61N1/025 ,  A61B18/1492 ,  A61N1/05 ,  A61N1/056 ,  A61N1/40 ,  A61B18/1402 ,  A61B2018/00702 ,  A61B2018/00875 ,  A61B2018/126 ,  A61B2034/2051 ,  A61B2090/065

Abstract: A method of locating infarcted myocardial tissue in a beating heart includes the step of inserting an impedance measuring tip of a catheter into the chamber of the beating heart, particularly the left or right ventricle, and measuring the impedance of the endocardium at various locations within the chamber of the beating heart. The values measured are compared to impedance values with a predetermined range of values to identify an infarcted area of myocardium and distinguish such area from normal myocardium. The measurements are also compared to a range of values for an infarction border zone. In accordance with the invention, the infarction border zone may be located. The infarction border zone is a significant source of arrhythmia, and particularly of ventricular tachycardia. Further, in accordance with the methods of the present invention, the risk of arrhythmia in a beating heart may be substantially reduced or eliminated by ablating endocardium within the infarction border zone utilizing the same catheter tip. Impedance measurements may also be utilized to assess the adequacy of the electrode-tissue contact, particularly in a fluid filled body organ or cavity. Further, the effectiveness of the ablation of the tissue may be determined by determining the degree of heating of the tissue by measuring the change in impedance in the area of ablation.

Abstract translation: 在搏动心脏中定位梗死心肌组织的方法包括将导管的阻抗测量尖端插入跳动心脏的腔室中，特别是左心室或右心室的步骤，以及测量内心内的不同位置处的心内膜的阻抗 心跳的房间。 将测量的值与具有预定范围值的阻抗值进行比较，以鉴定心肌的梗塞面积并将该区域与正常心肌区分开。 也将测量结果与梗塞边界区域的范围进行比较。 根据本发明，可以设置梗塞边界区域。 梗死边界区是心律失常的重要来源，特别是室性心动过速。 此外，根据本发明的方法，通过利用相同的导管尖端在梗塞边界区域中消融心内膜，可以显着减少或消除跳动心脏中的心律不齐的风险。 还可以使用阻抗测量来评估电极 - 组织接触的充分性，特别是在流体填充的身体器官或空腔中。 此外，可以通过测量消融区域中的阻抗变化来确定组织的加热程度来确定组织消融的有效性。

公开(公告)号：US20050150759A1

公开(公告)日：2005-07-14

申请号：US10508913

申请日：2003-03-24

Applicant: Isaac Chang

Inventor： Isaac Chang

IPC: B01J19/08 ,  B22F9/14 ,  C01B21/076 ,  C23C26/02 ,  C23C14/32

CPC classification number: B82Y30/00 ,  B01J19/088 ,  B01J2219/00094 ,  B01J2219/00126 ,  B01J2219/0809 ,  B01J2219/0822 ,  B01J2219/0828 ,  B01J2219/0839 ,  B01J2219/0841 ,  B01J2219/0871 ,  B01J2219/0879 ,  B22F9/14 ,  C01B21/0761 ,  C01P2004/04 ,  C01P2004/50 ,  C01P2004/64 ,  C23C24/04 ,  C23C26/02

Abstract: The invention relates to a process for the production of submicron particles (26) and comprises the steps of: (i) placing first and second electrodes, (6, 10) in a volume of coolant, such that the electrodes (6, 10) are mutually spaced, (ii) passing an electrical current across the electrodes to generate an electrical arc (24) between them, (iii) maintaining a stable arc (24) by controlling the relative spacing between the two electrodes (6, 10) to melt or evaporate and separate material from at least one of the electrodes (6, 10) such that droplets of said material are formed, and (iv) quenching said droplets to form said submicron particles (26) of the material in the coolant. The invention also relates to a powder coating method and to an apparatus for performing the methods of the invention.

Abstract translation: 本发明涉及一种生产亚微米颗粒（26）的方法，包括以下步骤：（i）将第一和第二电极（6,10）放置在一定体积的冷却剂中，使得电极（6,10） （ii）使电流通过电极以在它们之间产生电弧（24），（iii）通过控制两个电极（6,10）之间的相对间隔而保持稳定的电弧（24）至 熔化或蒸发并从至少一个电极（6,10）分离材料，使得形成所述材料的液滴，和（iv）淬灭所述液滴以形成冷却剂中的材料的所述亚微米颗粒（26）。 本发明还涉及一种粉末涂布方法以及用于实施本发明方法的装置。

公开(公告)号：US5673704A

公开(公告)日：1997-10-07

申请号：US654197

申请日：1996-05-28

Applicant: Francis E. Marchlinski ,  David S. Schwartzman ,  Mark S. Mirotznik ,  Kenneth R. Foster ,  Charles D. Gottlieb ,  Isaac Chang

Inventor： Francis E. Marchlinski ,  David S. Schwartzman ,  Mark S. Mirotznik ,  Kenneth R. Foster ,  Charles D. Gottlieb ,  Isaac Chang

IPC: A61B18/14 ,  A61N1/05 ,  A61N1/40 ,  A61B17/39

CPC classification number: A61N1/025 ,  A61B18/1492 ,  A61N1/05 ,  A61N1/056 ,  A61N1/40 ,  A61B18/1402 ,  A61B2018/00702 ,  A61B2018/00875 ,  A61B2018/126 ,  A61B2034/2051 ,  A61B2090/065

Abstract: A method of locating infarcted myocardial tissue in a beating heart includes the step of inserting an impedance measuring tip of a catheter into the chamber of the beating heart, particularly the left or right ventricle, and measuring the impedance of the endocardium at various locations within the chamber of the beating heart. The values measured are compared to impedance values with a predetermined range of values to identify an infarcted area of myocardium and distinguish such area from normal myocardium. The measurements are also compared to a range of values for an infarction border zone. In accordance with the invention, the infarction border zone may be located. The infarction border zone is a significant source of arrhythmia, and particularly of ventricular tachycardia. Further, in accordance with the methods of the present invention, the risk of arrhythmia in a beating heart may be substantially reduced or eliminated by ablating endocardium within the infarction border zone utilizing the same catheter tip. Impedance measurements may also be utilized to assess the adequacy of the electrode-tissue contact, particularly in a fluid filled body organ or cavity. Further, the effectiveness of the ablation of the tissue may be determined by determining the degree of heating of the tissue by measuring the change in impedance in the area of ablation.

Abstract translation: 在搏动心脏中定位梗死心肌组织的方法包括将导管的阻抗测量尖端插入跳动心脏的腔室中，特别是左心室或右心室的步骤，以及测量内心内的不同位置处的心内膜的阻抗 心跳的房间。 将测量的值与具有预定范围值的阻抗值进行比较，以鉴定心肌的梗塞面积并将该区域与正常心肌区分开。 也将测量结果与梗塞边界区域的范围进行比较。 根据本发明，可以设置梗塞边界区域。 梗死边界区是心律失常的重要来源，特别是室性心动过速。 此外，根据本发明的方法，通过利用相同的导管尖端在梗塞边界区域中消融心内膜，可以显着减少或消除跳动心脏中的心律不齐的风险。 还可以使用阻抗测量来评估电极 - 组织接触的充分性，特别是在流体填充的身体器官或空腔中。 此外，可以通过测量消融区域中的阻抗变化来确定组织的加热程度来确定组织消融的有效性。