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公开(公告)号：US06350934B1
公开(公告)日：2002-02-26
申请号：US08679645
申请日：1996-07-12
Applicant: Michael G. Zwick , Brent E. Edington , James A. McSwiggen , Patricia Ann Owens Merlo , Lining Guo , Thomas A. Skokut , Scott A. Young , Otto Folkerts , Donald J. Merlo
Inventor： Michael G. Zwick , Brent E. Edington , James A. McSwiggen , Patricia Ann Owens Merlo , Lining Guo , Thomas A. Skokut , Scott A. Young , Otto Folkerts , Donald J. Merlo
IPC: C12N504
CPC classification number: C12N15/113 , C12N9/0083 , C12N9/1051 , C12N15/8216 , C12N15/8218 , C12N15/8243 , C12N15/8245 , C12N15/8247 , C12N15/8255 , C12N2310/12 , C12N2310/121 , C12N2310/122
Abstract: The present invention relates to nucleic acid molecules encoding delta 9 desaturase gene, and expression vectors, plant cells, and transgenic plants expressing delta 9 desaturase nucleic acid. The nucleic acid molecules of the present invention can be used, for example, to decrease delta 9 desaturase activity in plant cells, resulting in decreased unsaturated fatty acid production.
Abstract translation: 本发明涉及编码Δ9去饱和酶基因的核酸分子和表达载体，植物细胞和表达Δ9去饱和酶核酸的转基因植物。 本发明的核酸分子可以用于例如降低植物细胞中δ9去饱和酶的活性，导致不饱和脂肪酸的产生降低。
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2.发明授权Enzymatic nucleic acid treatment of diseases or conditions related to levels of epidermal growth factor receptors 失效与表皮生长因子受体水平相关的疾病或病症的酶学核酸治疗
公开(公告)号：US06057156A
公开(公告)日：2000-05-02
申请号：US985162
申请日：1997-12-04
Applicant: Saghir Akhtar , Patricia Fell , James A. McSwiggen
Inventor： Saghir Akhtar , Patricia Fell , James A. McSwiggen
IPC: C12N15/09 , A61K31/7088 , A61K38/00 , A61P35/00 , C12N5/10 , C12N9/00 , C12N15/113 , C12Q1/68 , C07H21/04 , C12N15/63 , C12N15/85
CPC classification number: C12N15/1138 , A61K38/00 , C12N2310/121 , C12N2310/122 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/335 , C12N2310/346
Abstract: Enzymatic nucleic acid molecules which cleave EGFR RNA.
Abstract translation: 切割EGFR RNA的酶学核酸分子。
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公开(公告)号：US20220144629A1
公开(公告)日：2022-05-12
申请号：US17096738
申请日：2020-11-12
Applicant: Trevor Percival Castor , Vasudevacharya Jayarama , James A. McSwiggen
Inventor： Trevor Percival Castor , Vasudevacharya Jayarama , James A. McSwiggen
IPC: B82Y5/00 , C12N15/113 , B82Y40/00 , C07K14/54
Abstract: The present invention pertains to the nanoencapsulation of siRNA and other biologics in phospholipid nanosomes for the improved delivery of siRNA and other biologics to targeted diseased human or animal organs and human or animal cells and apparatus and methods for making the same. In embodiments of the present invention, novel siRNAs were designed to down regulate CCR5 and CD4, based on an analysis of all known alternative transcripts for each gene from both human and monkey (Macaca mulatta) genomes. Embodiments of the present invention feature supercritical, critical and near critical fluids. Embodiments of the present invention also pertain to down regulation of CXCR4 receptor and targeting of nanosomes containing specific siRNA sequences to cells expressing those receptors on the cell surface by coating them with specific ligands. These include ligands for the receptors CCR5, CD4 and CXCR4.
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4.发明授权Method and reagent for the treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor 失效用于治疗与血管内皮生长因子受体水平相关的疾病或病症的方法和试剂公开(公告)号：US06566127B1
公开(公告)日：2003-05-20
申请号：US09371772
申请日：1999-08-10
Applicant: Pamela Pavco , James A. McSwiggen , Dan T. Stinchcomb , Jaime Escobedo
Inventor： Pamela Pavco , James A. McSwiggen , Dan T. Stinchcomb , Jaime Escobedo
IPC: C12N500
CPC classification number: C12N15/1138 , A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3521
Abstract: The present invention relates to nucleic acid molecules which modulate the synthesis, expression and/or stability of an mRNA encoding one or more receptors of vascular endothelial growth factor.
Abstract translation: 本发明涉及调节编码血管内皮生长因子的一种或多种受体的mRNA的合成，表达和/或稳定性的核酸分子。
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公开(公告)号：US6022962A
公开(公告)日：2000-02-08
申请号：US98293
申请日：1998-06-16
Applicant: Bharat Chowrira , James A. McSwiggen
Inventor： Bharat Chowrira , James A. McSwiggen
CPC classification number: C12N15/113 , C12N15/101 , C12N15/1131 , C12N15/1136 , C12N15/1138 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/32 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3523 , C12N2310/3527 , C12N2310/3533 , C12N2310/3535
Abstract: Hairpin ribozyme lacking a substrate moiety, comprising atleast six bases in helix 2 and able to base-pair with a separate substrate RNA, wherein the said ribozyme comprises one or more bases 3' of helix 3 able to base-pair with the said substrate RNA to form a helix 5 and wherein the said ribozyme can cleave and/or ligate said separate RNA(s) in trans.
Abstract translation: 缺少底物部分的发夹核酶，其包含螺旋2中至少6个碱基并且能够与单独的底物RNA碱基配对，其中所述核酶包含一个或多个能够与所述底物RNA碱基配对的螺旋3的3'碱基 以形成螺旋5，并且其中所述核酶可以以反式方式切割和/或连接所述分离的RNA。
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Patent Agency Ranking
6.发明授权公开(公告)号：US06623962B1
公开(公告)日：2003-09-23
申请号：US09401063
申请日：1999-09-22
Applicant: Saghir Akhtar , Patricia Fell , James A. McSwiggen
Inventor： Saghir Akhtar , Patricia Fell , James A. McSwiggen
IPC: C07H2104
CPC classification number: C12N15/1138 , A61K38/00 , C12N2310/121 , C12N2310/122 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/335 , C12N2310/346 , C12N2310/3521
Abstract: Enzymatic nucleic acid molecules which cleave EGFR RNA.
Abstract translation: 切割EGFR RNA的酶学核酸分子。
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7.发明申请RNA Interference Mediated Inhibition of Protein Tyrosine Phosphatase-1B (PTP-1B) Gene Expression Using Short Interfering RNA 审中-公开RNA干扰介导的使用短干扰RNA的蛋白酪氨酸磷酸酶-1B（PTP-1B）基因表达的抑制公开(公告)号：US20090233983A1
公开(公告)日：2009-09-17
申请号：US12245486
申请日：2008-10-03
Applicant: James A. McSwiggen
Inventor： James A. McSwiggen
CPC classification number: C12N15/1137 , C12N2310/14 , C12Y301/03048
Abstract: The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications associated with insulin response. Specifically, the invention relates to small interfering RNA (siRNA) molecules capable of mediating RNA interference (RNAi) against PTP-1B polypeptide and polynucleotide targets.
Abstract translation: 本发明涉及可用于调节多种应用中的基因表达的方法和试剂，包括用于与胰岛素反应相关的治疗，诊断，靶标验证和基因组发现应用。 具体地，本发明涉及能够介导针对PTP-1B多肽和多核苷酸靶标的RNA干扰（RNAi）的小干扰RNA（siRNA）分子。
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公开(公告)号：US5807743A
公开(公告)日：1998-09-15
申请号：US758306
申请日：1996-12-03
Applicant: Dan T. Stinchcomb , James A. McSwiggen
Inventor： Dan T. Stinchcomb , James A. McSwiggen
IPC: A61K38/00 , C12N15/113 , C07H21/09 , C12N15/85 , C12Q1/68
CPC classification number: C12N15/1138 , A61K38/00 , C12N2310/121 , C12N2310/122
Abstract: A nucleic acid molecule which blocks synthesis and/or expression of an IL-2R encoded RNA, wherein said nucleic acid molecule is used to treat graft rejection, an autoimmune disease, cancer, psoriasis, an allergy or other inflammatory disease.
Abstract translation: 阻断IL-2R编码RNA的合成和/或表达的核酸分子，其中所述核酸分子用于治疗移植排斥反应，自身免疫疾病，癌症，牛皮癣，过敏或其它炎性疾病。
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公开(公告)号：US11981714B2
公开(公告)日：2024-05-14
申请号：US17096738
申请日：2020-11-12
Applicant: Trevor Percival Castor , Vasudevacharya Jayarama , James A McSwiggen
Inventor： Trevor Percival Castor , Vasudevacharya Jayarama , James A McSwiggen
IPC: C07K14/54 , B82Y5/00 , B82Y40/00 , C12N15/113
CPC classification number: C07K14/5446 , B82Y5/00 , B82Y40/00 , C12N15/113
Abstract: The present invention pertains to the nanoencapsulation of siRNA and other biologics in phospholipid nanosomes for the improved delivery of siRNA and other biologics to targeted diseased human or animal organs and human or animal cells and apparatus and methods for making the same. In embodiments of the present invention, novel siRNAs were designed to down regulate CCR5 and CD4, based on an analysis of all known alternative transcripts for each gene from both human and monkey (Macaca mulatta) genomes. Embodiments of the present invention feature supercritical, critical and near critical fluids. Embodiments of the present invention also pertain to down regulation of CXCR4 receptor and targeting of nanosomes containing specific siRNA sequences to cells expressing those receptors on the cell surface by coating them with specific ligands. These include ligands for the receptors CCR5, CD4 and CXCR4.
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10.发明授权公开(公告)号：US07022828B2
公开(公告)日：2006-04-04
申请号：US10156306
申请日：2002-05-28
Applicant: James A. McSwiggen
Inventor： James A. McSwiggen
IPC: C07H21/02
CPC classification number: C12N15/1137 , A61K38/00 , C12N15/113 , C12N15/1138 , C12N2310/12 , C12N2310/121 , C12N2310/13 , C12N2310/14 , C12N2310/18 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/332 , C12N2310/346 , C12N2310/3521
Abstract: The present invention relates to nucleic acid molecules, including antisense and enzymatic nucleic acid molecules, such as hammerhead ribozymes, DNAzymes, allozymes, aptamers, decoys and siRNA (RNAi), which modulate the expression or function of IKK genes, such as IKK-gamma, IKK-alpha, or IKK-beta, and PKR genes.
Abstract translation: 本发明涉及核酸分子，包括反义和酶核酸分子，例如锤头核酶，DNA酶，异构酶，适体，诱饵和siRNA（RNAi），其调节IKK基因如IKK-γ的表达或功能 ，IKK-α或IKK-β和PKR基因。
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