公开(公告)号：US20230402129A1

公开(公告)日：2023-12-14

申请号：US18036375

申请日：2021-11-23

Applicant: The University of British Columbia ,  The James Hutton Institute

Inventor： Wilfred Jefferies ,  Paolo Ribeca

IPC: G16B35/20 ,  G16B20/40 ,  G16B40/00

CPC classification number: G16B35/20 ,  G16B20/40 ,  G16B40/00

Abstract: The present invention provides a method of epitope-based vaccine design. The method comprising: a) providing one or more target amino acid sequence(s); b) optionally discarding peptides based on one or more predetermined features; c) parsing and selecting MHC I and/or MHC II binding peptides from said sequences; and d) assembling the MHC I and/or MHC II binding peptides optionally with linkers to produce an assembly of peptides.

公开(公告)号：US09688964B2

公开(公告)日：2017-06-27

申请号：US14429620

申请日：2013-09-20

Applicant: THE JAMES HUTTON INSTITUTE

Inventor： Andrew John Love ,  Mikhail Emmanuilovich Talianski ,  Sean Nicholas Chapman ,  Jane Shaw

IPC: C12N7/00 ,  A61K9/51 ,  B82Y5/00

CPC classification number: C12N7/00 ,  A61K9/5123 ,  B82Y5/00 ,  C12N2710/20023 ,  C12N2710/20031 ,  C12N2770/00023 ,  C12N2770/00031 ,  C12N2770/18023 ,  C12N2770/18031 ,  C12N2770/34023 ,  C12N2770/34031 ,  C12N2770/40023 ,  C12N2770/40031

Abstract: There is described a process for production of metal-coated virus particles or metallic nanoparticles, said process comprising admixing virus particles with plant material with reducing power and a metal salt, wherein the process can be provided in planta or ex planta and the virus particles aid the production of the metal-coated virus particles or metallic nanoparticles.

公开(公告)号：US20240277888A1

公开(公告)日：2024-08-22

申请号：US18580652

申请日：2022-07-20

Applicant: CELLUCOMP LIMITED ,  THE JAMES HUTTON INSTITUTE

Inventor： Eric Arron WHALE ,  David Gwyddon HEPWORTH ,  Andrew John LOVE ,  Julie Nicola SQUIRES

IPC: A61L15/60 ,  A61L15/42 ,  C08L97/02

CPC classification number: A61L15/60 ,  A61L15/425 ,  C08L97/02 ,  A61L2300/404

Abstract: The present invention relates to a process for preparing an antimicrobial cellulose-containing microporous superabsorbent composition from an herbaceous plant material, the process comprising the step of comminuting dry granulated herbaceous plant material to form microparticles having an average particle diameter of from 100 μm to 800 μm; to obtain the cellulose-containing microporous superabsorbent composition.

公开(公告)号：USPP33658P3

公开(公告)日：2021-11-23

申请号：US17035439

申请日：2020-09-28

Applicant: James Hutton Ltd.

Inventor： Sophia N Jennings

IPC: A01H5/08 ,  A01H6/74

Abstract: A new cultivar of Rubus idaeus plant named ‘Skye’ that is characterized by its canes that have thorns that are greyed-purple in color, its canes that require low chill hours to flower, its fruits that have a glossy surface, and its summer floricane fruit production and very late autumn primocane fruit production.

公开(公告)号：USPP33657P3

公开(公告)日：2021-11-23

申请号：US17035414

申请日：2020-09-28

Applicant: James Hutton Ltd.

Inventor： Sophia N Jennings

IPC: A01H5/08 ,  A01H6/74

Abstract: A new cultivar of Rubus plant named ‘Glen Mor’ that is characterized by its spineless canes, its resistance to Phytophthora root rot, its pink petioles on actively growing vegetative canes, its early summer fruit production on floricanes, its early summer fruit production on floricanes, its late fruit laterals low on the floricane during the summer allowing a longer fruit season, and its tip fruit in autumn on the top 6 to 10 buds on the primocane.

公开(公告)号：US20180353988A1

公开(公告)日：2018-12-13

申请号：US15760462

申请日：2016-09-16

Applicant: The James Hutton Institute

Inventor： Graham Gaskin ,  Stephen John Hillier

IPC: B05B17/06

CPC classification number: B05B17/0676 ,  B05B17/0623 ,  B05B17/0653 ,  B05B17/0669 ,  B06B1/0238 ,  B06B2201/77

Abstract: A compact apparatus for atomisation of fluid samples comprises a sonotrode (11), placed so that an ultrasonic wave emitted by the sonotrode is directed through a channel (25) in a separate channel device (21) and reflected by from the interface (26) in a high-low impedance transition zone (Tz), so that a standing wave is formed within the channel. A positive air flow through the channel, driven by a pressure differential at each end of the channel, interacts with the working fluid or slurry being delivered by a fluid delivery device (30) to atomise it. The speed of the air flow and the dispersal, homogeneity, and size of particles in the slurry sample can be controlled by varying the shape of the channel outlet.

公开(公告)号：US06635085B1

公开(公告)日：2003-10-21

申请号：US09640599

申请日：2000-08-17

Applicant: James Charles Caffey ,  Riyad Moe ,  Matthew Allen Freund ,  James Hutton

Inventor： James Charles Caffey ,  Riyad Moe ,  Matthew Allen Freund ,  James Hutton

IPC: A61F224

CPC classification number: A61F2/2418 ,  A61F2/2415 ,  Y10S623/90

Abstract: A stent includes a stent member having a plurality of post members formed therein. Each post member is connected to an adjacent post member by an interconnecting portion. A plurality of leg members extend from the stent member. The stent may be molded within a flexible polymer valve. The legs stabilize and locate the stent in the mold. Upon completion of the molding process, the legs can be separated from the stent.

Abstract translation: 支架包括其中形成有多个柱构件的支架构件。 每个柱构件通过互连部分连接到相邻的柱构件。 多个腿部构件从支架构件延伸。 支架可以在柔性聚合物阀内模制。 腿部稳定并将支架定位在模具中。 在完成模制过程之后，腿可以与支架分离。

公开(公告)号：US20240254515A1

公开(公告)日：2024-08-01

申请号：US18564149

申请日：2022-05-26

Applicant: The University Of British Columbia ,  The James Hutton Institute

Inventor： Wilfred A. JEFFERIES ,  Paolo RIBECA

IPC: C12N15/86 ,  A61K39/00 ,  A61K39/20 ,  A61K39/215 ,  A61K48/00 ,  A61P31/14 ,  A61P37/04

CPC classification number: C12N15/86 ,  A61K39/20 ,  A61K39/215 ,  A61K48/005 ,  A61P31/14 ,  A61P37/04 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/575 ,  C12N2770/20043 ,  C12N2770/20044 ,  C12N2770/36143 ,  C12N2770/36144 ,  C12N2770/36244

Abstract: The present invention relates to an expression vector that encodes all or a portion of replicon proteins from a positive stranded virus, wherein expression of the replicon proteins is under the control of CMV and T7 promoters, and wherein expression of a payload is under the control of a sub-genomic promoter. Also provided are methods of using the vector in therapeutics and vaccines.

公开(公告)号：US20240238409A1

公开(公告)日：2024-07-18

申请号：US18558241

申请日：2022-05-05

Applicant: THE UNIVERSITY OF BRITISH COLUMBIA ,  THE JAMES HUTTON INSTITUTE

Inventor： Wilfred JEFFERIES ,  Paolo RIBECA

IPC: A61K39/215 ,  A61K39/00 ,  C12N7/00 ,  C12N15/86

CPC classification number: A61K39/215 ,  C12N7/00 ,  C12N15/86 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55555 ,  C12N2710/10041 ,  C12N2710/24043 ,  C12N2760/20241 ,  C12N2770/20034

Abstract: The present invention provides multi-epitope vaccines comprising or capable of expressing one or more concatemers of epitopes from a viral pathogen, namely, SARS-COV-2. wherein at least a portion of the epitopes are from conserved viral proteins and wherein the vaccine comprises or expresses epitopes for all MHC I and MHC II alleles with a frequency >1% in the target population.

公开(公告)号：US11548921B2

公开(公告)日：2023-01-10

申请号：US16617944

申请日：2018-05-31

Applicant: THE JAMES HUTTON INSTITUTE

Inventor： Andrew John Love ,  Mikhail Emmanuilovich Talianski ,  Kara McGeachy

IPC: C07K14/315 ,  C07K14/005

Abstract: The present invention relates to macromolecular complexes comprising micron-scale networks which include binding motifs thereon which allow the covalent bonding of the micron-scale networks to particles which provide nanoscale display surfaces. In particular the present invention relates to micron-scale networks of TMV coat proteins comprising a peptide tag (e.g. SpyTag) and particles providing a nanoscale display surface comprising GFP and a corresponding binding protein (e.g. SpyCatcher) wherein the peptide tag and binding protein pair are capable of spontaneously forming a covalent bond.