公开(公告)号：US20050032829A1

公开(公告)日：2005-02-10

申请号：US10856466

申请日：2004-05-28

Applicant: Kyle Lindstrom ,  Luke Dressel ,  Jason Bonk

Inventor： Kyle Lindstrom ,  Luke Dressel ,  Jason Bonk

IPC: A61K31/4745 ,  C07D20060101 ,  C07D471/02 ,  C07D471/04 ,  C07D471/14

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: A process and intermediates for preparing 1H-imidazo[4,5-c]pyridin-4-amines are disclosed. The process includes providing a 7H-imidazo[4,5-c]tetrazolo[1,5-a]pyridine and converting a 7H-imidazo[4,5-c]tetrazolo[1,5-a]pyridine to a 1H-imidazo[4,5-c]pyridin-4-amine.

Abstract translation: 公开了制备1H-咪唑并[4,5-c]吡啶-4-胺的方法和中间体。 该方法包括提供7H-咪唑并[4,5-c]四唑并[1,5-a]吡啶，并将7H-咪唑并[4,5-c]四唑并[1,5-a]吡啶转化为1H- 咪唑并[4,5-c]吡啶-4-胺。

公开(公告)号：US20060100229A1

公开(公告)日：2006-05-11

申请号：US11097715

申请日：2005-04-01

Applicant: David Hays ,  Michael Danielson ,  John Gerster ,  Shri Niwas ,  Ryan Prince ,  Tushar Kshirsagar ,  Philip Heppner ,  William Moser ,  Joan Moseman ,  Matthew Radmer ,  Maureen Kavanagh ,  Sarah Strong ,  Jason Bonk

Inventor： David Hays ,  Michael Danielson ,  John Gerster ,  Shri Niwas ,  Ryan Prince ,  Tushar Kshirsagar ,  Philip Heppner ,  William Moser ,  Joan Moseman ,  Matthew Radmer ,  Maureen Kavanagh ,  Sarah Strong ,  Jason Bonk

IPC: C07D471/02 ,  A61K31/4745

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

公开(公告)号：US08065174B2

公开(公告)日：2011-11-22

申请号：US12170627

申请日：2008-07-10

Applicant: Jason Bonk ,  Kristin Chouteau ,  Alex Costa ,  Michael Hanes ,  Jill Heddleson ,  Melinda Jones ,  Brenda Lahaie

Inventor： Jason Bonk ,  Kristin Chouteau ,  Alex Costa ,  Michael Hanes ,  Jill Heddleson ,  Melinda Jones ,  Brenda Lahaie

IPC: G06Q90/00

CPC classification number: G06Q10/06 ,  G06Q10/063114 ,  G06Q10/06312 ,  G06Q10/06313 ,  G06Q10/06393

Abstract: Systems, methods and computer-readable media for evaluating business-critical criteria relating to exploring entity mobility/productivity opportunities are provided. A method according to the invention may include calculating a hierarchy of a plurality of decision elements regarding the opportunities. The calculating can include forming a matrix of values corresponding to the relative importance of each of the decision elements with respect to one another. The method can also include calculating a weighted composite score for each sub-process specified in each of the plurality of decision elements. The method may include compiling a favorability rating for each sub-process. The favorability rating for each sub-process may be based, at least in part, on the weighted composite score for each sub-process and the matrix of values corresponding to the relative importance of each of the decision elements with respect to one another. Finally, the method may include ranking each favorability rating to form a favorability index.

Abstract translation: 提供了用于评估与探索实体移动性/生产力机会相关的业务关键标准的系统，方法和计算机可读介质。 根据本发明的方法可以包括计算关于机会的多个决策元素的层级。 所述计算可以包括形成对应于每个判定元件相对于彼此的相对重要性的值的矩阵。 该方法还可以包括计算用于在多个决策元素中的每一个中指定的每个子处理的加权综合得分。 该方法可以包括编译每个子过程的有利度等级。 每个子过程的有利性评级可以至少部分地基于每个子过程的加权综合得分和对应于每个决策元素相对于彼此的相对重要性的值的矩阵。 最后，该方法可以包括排列每个有利度等级以形成有利指数。

公开(公告)号：US20070287724A1

公开(公告)日：2007-12-13

申请号：US11570707

申请日：2005-06-17

Applicant: Doris Stoermer ,  Joseph Dellaria ,  David Amos ,  Bernhard Zimmermann ,  Luke Dressel ,  Jason Bonk ,  Matthew Radmer

Inventor： Doris Stoermer ,  Joseph Dellaria ,  David Amos ,  Bernhard Zimmermann ,  Luke Dressel ,  Jason Bonk ,  Matthew Radmer

IPC: A61K31/4745 ,  A61K31/437 ,  A61P31/12 ,  A61P35/00 ,  C07D471/04 ,  C07D471/14

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, 1,5-naphthyridines, 1,5-tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 咪唑并喹啉，吡啶和萘啶环体系（特别是在1位被环状取代基取代的喹啉，四氢喹啉，吡啶，1,5-萘啶，1,5-四氢萘并吡啶），含有这些化合物的药物组合物和 公开了这些化合物作为免疫调节剂的用途，用于在动物中诱导细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病的方法。

公开(公告)号：US20060142202A1

公开(公告)日：2006-06-29

申请号：US11360071

申请日：2006-02-23

Applicant: Sefik Alkan ,  William Kieper ,  John Vasilakos ,  Jason Bonk ,  George Griesgraber ,  Kenneth Lipson ,  Jie Liu ,  James Mendoza ,  Doris Stoermer ,  Paul Wightman ,  Naiyong Jing ,  William Schultz

Inventor： Sefik Alkan ,  William Kieper ,  John Vasilakos ,  Jason Bonk ,  George Griesgraber ,  Kenneth Lipson ,  Jie Liu ,  James Mendoza ,  Doris Stoermer ,  Paul Wightman ,  Naiyong Jing ,  William Schultz

IPC: A61K38/09 ,  A61K31/4745

CPC classification number: A61K31/4745 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851

Abstract: The present invention provides immunomodulatory compositions include an immune response modifier moiety coupled to a targeting moiety. In another aspect, the invention provides methods of providing targeted delivery of an IRM, generating a localized immune response, and treating a condition in a subject. Generally, the methods include administering to the subject an immunomodulatory composition that includes an immune response modifier moiety coupled to a targeting moiety that recognizes a delivery target.

Abstract translation: 本发明提供免疫调节组合物包括与靶向部分偶联的免疫应答调节剂部分。 在另一方面，本发明提供了提供IRM的靶向递送，产生局部免疫应答和治疗受试者的病症的方法。 通常，所述方法包括向受试者施用免疫调节组合物，其包含与识别递送目标的靶向部分偶联的免疫应答调节剂部分。

公开(公告)号：US20100010846A1

公开(公告)日：2010-01-14

申请号：US12170627

申请日：2008-07-10

Applicant: Jason Bonk ,  Kristin Chouteau ,  Alex Costa ,  Michael Hanes ,  Jill Heddleson ,  Melinda Jones ,  Brenda Lahaie

Inventor： Jason Bonk ,  Kristin Chouteau ,  Alex Costa ,  Michael Hanes ,  Jill Heddleson ,  Melinda Jones ,  Brenda Lahaie

IPC: G06Q10/00

CPC classification number: G06Q10/06 ,  G06Q10/063114 ,  G06Q10/06312 ,  G06Q10/06313 ,  G06Q10/06393

Abstract: Systems, methods and computer-readable media for evaluating business-critical criteria relating to exploring entity mobility/productivity opportunities are provided. A method according to the invention may include calculating a hierarchy of a plurality of decision elements regarding the opportunities. The calculating can include forming a matrix of values corresponding to the relative importance of each of the decision elements with respect to one another. The method can also include calculating a weighted composite score for each sub-process specified in each of the plurality of decision elements. The method may include compiling a favorability rating for each sub-process. The favorability rating for each sub-process may be based, at least in part, on the weighted composite score for each sub-process and the matrix of values corresponding to the relative importance of each of the decision elements with respect to one another. Finally, the method may include ranking each favorability rating to form a favorability index.

Abstract translation: 提供了用于评估与探索实体移动性/生产力机会相关的业务关键标准的系统，方法和计算机可读介质。 根据本发明的方法可以包括计算关于机会的多个决策元素的层级。 所述计算可以包括形成对应于每个判定元件相对于彼此的相对重要性的值的矩阵。 该方法还可以包括计算用于在多个决策元素中的每一个中指定的每个子处理的加权综合得分。 该方法可以包括编译每个子过程的有利度等级。 每个子过程的有利性评级可以至少部分地基于每个子过程的加权综合得分和对应于每个决策元素相对于彼此的相对重要性的值的矩阵。 最后，该方法可以包括排列每个有利度等级以形成有利指数。