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公开(公告)号：US08507464B2
公开(公告)日：2013-08-13
申请号：US13163303
申请日：2011-06-17
Applicant: Mark Matteucci , Jian-Xin Duan , Hailong Jiao , Jacob Kaizerman
Inventor： Mark Matteucci , Jian-Xin Duan , Hailong Jiao , Jacob Kaizerman
IPC: A61K31/675 , A61K31/665 , A61K31/67 , A61K31/664 , C07F9/655 , C07F9/6506 , C07F9/6553 , C07F9/24 , A61P35/00
CPC classification number: A61K31/675 , A61K31/337 , A61K31/513 , A61K31/7068 , A61K33/24 , C07F9/6506 , C07F9/65397
Abstract: Phosphoramidate alkylator prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents.
Abstract translation: 当单独施用或与一种或多种抗肿瘤剂组合时，氨基磷酸烷基酯前体药物可用于治疗癌症。
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公开(公告)号：US20100104549A1
公开(公告)日：2010-04-29
申请号：US12594802
申请日：2008-04-07
Applicant: Damian Handisides , Stewart Kroll , Jian-Xin Duan , Harold E. Selick
Inventor： Damian Handisides , Stewart Kroll , Jian-Xin Duan , Harold E. Selick
CPC classification number: A61K31/70 , A61K31/17 , A61K31/4015 , A61K31/4035 , A61K31/4439 , A61K31/4965 , A61K38/30 , A61K38/47 , A61K45/06 , C12Y302/01 , A61K2300/00
Abstract: The co-administration of glufosfamide and a glucose lowering drug other than insulin is efficacious in cancer treatment.
Abstract translation: 除了胰岛素以外，葡糖胺和葡萄糖降低药物的共同给药在癌症治疗中是有效的。
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公开(公告)号：US20080214576A1
公开(公告)日：2008-09-04
申请号：US11791197
申请日：2005-11-27
Applicant: Mark Matteucci , Jian-Xin Duan , Photon Rao
Inventor： Mark Matteucci , Jian-Xin Duan , Photon Rao
IPC: A61K31/519 , C07D491/147 , C07D221/18 , A61P35/00 , A61K31/4365 , A61K31/437 , C07D495/04
CPC classification number: C07D471/04 , C07D221/18 , C07D487/04 , C07D491/147 , C07D495/04
Abstract: Compositions and methods for treating cancer and other hyperproliferatice disease conditions with topoisomerase inhibitors and their prodrugs are disclosed.
Abstract translation: 公开了用拓扑异构酶抑制剂及其前体药物治疗癌症和其它过度增生症病症的组合物和方法。
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公开(公告)号：US20070060534A1
公开(公告)日：2007-03-15
申请号：US11478937
申请日：2006-06-30
Applicant: Mark Matteucci , Jian-Xin Duan , Xiaohong Cai
Inventor： Mark Matteucci , Jian-Xin Duan , Xiaohong Cai
IPC: A61K31/704 , C07H15/24
CPC classification number: C07H15/24
Abstract: Anthracycline analogs and their bioconjugates are useful as anticancer agents.
Abstract translation: 蒽环霉素类似物及其生物缀合物可用作抗癌剂。
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公开(公告)号：US20070015771A1
公开(公告)日：2007-01-18
申请号：US11351347
申请日：2006-02-08
Applicant: Mark Matteucci , Photon Rao , Jian-Xin Duan
Inventor： Mark Matteucci , Photon Rao , Jian-Xin Duan
IPC: C07D487/02 , C07D471/02 , C07D455/02 , A61K31/519 , A61K31/4745 , A61K31/4184 , A61K31/416 , A61K31/403
CPC classification number: C07D417/06 , C07D209/42 , C07D231/56 , C07D405/06 , C07D413/06 , C07D471/04
Abstract: Lonidamine analogs are useful in the treatment and prevention of cancer, benign prostatic hyperplasia, macular degeneration and prostatic intraepithelial neoplasia, or for use as an antispermatigenic agent.
Abstract translation: 罗丹明胺类似物可用于治疗和预防癌症，良性前列腺增生，黄斑变性和前列腺上皮内瘤变，或用作抗致细胞药物。
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Patent Agency Ranking
公开(公告)号：US20090312276A1
公开(公告)日：2009-12-17
申请号：US12484104
申请日：2009-06-12
Applicant: Mark Matteucci , Photon Rao , Jian-Xin Duan
Inventor： Mark Matteucci , Photon Rao , Jian-Xin Duan
IPC: A61K31/704 , A61K31/7048 , A61P35/00
CPC classification number: A61K31/415 , A61K31/4166 , A61K31/44 , A61K31/5377 , A61K47/54 , A61K47/559 , A61K47/6899 , B82Y5/00
Abstract: Hypoxia-activated prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents.
Abstract translation: 当单独施用或与一种或多种抗肿瘤剂组合时，缺氧活化的前药可用于治疗癌症。
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公开(公告)号：US20060258656A1
公开(公告)日：2006-11-16
申请号：US10549545
申请日：2004-03-29
Applicant: Mark Matteucci , Photon Rao , Jian-Xin Duan
Inventor： Mark Matteucci , Photon Rao , Jian-Xin Duan
IPC: A61K31/5377 , A61K31/4166
CPC classification number: A61K31/415 , A61K31/4166 , A61K31/44 , A61K31/5377 , A61K47/54 , A61K47/559 , A61K47/6899 , B82Y5/00
Abstract: Hypoxia-activated prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents.
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8.发明授权Treatment of cancer with glufosfamide in patients not receiving insulin therapy 有权在接受胰岛素治疗的患者中，用氟磷酰胺治疗癌症公开(公告)号：US08765690B2
公开(公告)日：2014-07-01
申请号：US12594802
申请日：2008-04-07
Applicant: Damian Handisides , Stewart Kroll , Jian-Xin Duan , Harold E. Selick
Inventor： Damian Handisides , Stewart Kroll , Jian-Xin Duan , Harold E. Selick
IPC: A61K31/70
CPC classification number: A61K31/70 , A61K31/17 , A61K31/4015 , A61K31/4035 , A61K31/4439 , A61K31/4965 , A61K38/30 , A61K38/47 , A61K45/06 , C12Y302/01 , A61K2300/00
Abstract: The co-administration of glufosfamide and a glucose lowering drug other than insulin is efficacious in cancer treatment.
Abstract translation: 除了胰岛素以外，葡糖胺和葡萄糖降低药物的共同给药在癌症治疗中是有效的。
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公开(公告)号：US08552048B2
公开(公告)日：2013-10-08
申请号：US12521290
申请日：2007-12-21
Applicant: Steve Ammons , Jian-Xin Duan , Donald Jung , Mark Matteucci
Inventor： Steve Ammons , Jian-Xin Duan , Donald Jung , Mark Matteucci
IPC: A01N57/00 , A01N57/26 , A61K31/675 , A61K31/66
CPC classification number: A61K31/535 , A61K9/0019 , A61K9/19
Abstract: Compositions containing, and, methods administering, TH302, are useful in treatment of cancer and other hyper-proliferative diseases.
Abstract translation: 含TH302的组合物和施用方法可用于治疗癌症和其他高增殖性疾病。
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公开(公告)号：US08003625B2
公开(公告)日：2011-08-23
申请号：US11993822
申请日：2006-06-29
Applicant: Mark Matteucci , Jian-Xin Duan , Hailong Jiao , Jacob Kaizerman
Inventor： Mark Matteucci , Jian-Xin Duan , Hailong Jiao , Jacob Kaizerman
IPC: A61K31/675 , A61K31/665 , C07F9/22 , A61P35/00
CPC classification number: A61K31/675 , A61K31/337 , A61K31/513 , A61K31/7068 , A61K33/24 , C07F9/6506 , C07F9/65397
Abstract: Phosphoramidate alkylator prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents.
Abstract translation: 当单独施用或与一种或多种抗肿瘤剂组合时，氨基磷酸烷基酯前体药物可用于治疗癌症。
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