公开(公告)号：US07189359B2

公开(公告)日：2007-03-13

申请号：US10900649

申请日：2004-07-28

Applicant: Shih-Jun Yuan ,  Jing-Tang Yang ,  Jer-Liang Yeh ,  Chih-Sheng Yu ,  Yi-Chiuen Hu ,  Chien-Jen Chen

Inventor： Shih-Jun Yuan ,  Jing-Tang Yang ,  Jer-Liang Yeh ,  Chih-Sheng Yu ,  Yi-Chiuen Hu ,  Chien-Jen Chen

IPC: G01N15/06 ,  B32B5/02 ,  B32B27/04 ,  B32B27/12 ,  B32B27/00

CPC classification number: G01N27/745 ,  G01N33/5438 ,  Y10T436/11

Abstract: A detecting device for biochemical detections is provided. The detecting device includes a first substrate, a magnetic layer located on the first substrate, an isolation layer located on the magnetic layer, at least a first electrode located on the isolation layer, a first dielectric layer located on the first electrode, a first hydrophobic layer located on the first dielectric layer, a second substrate, at least a second electrode located on the second substrate and having a cathode and an anode, a second dielectric layer located on the second electrode' and a second hydrophobic layer located on the second dielectric layer. The first electrode is zigzag-shaped, and the cathode and the anode of the second electrode are comb-shaped and interlaced with each other.

Abstract translation: 提供了用于生化检测的检测装置。 所述检测装置包括第一基板，位于所述第一基板上的磁性层，位于所述磁性层上的隔离层，位于所述隔离层上的至少第一电极，位于所述第一电极上的第一电介质层， 位于第一电介质层上的第二电介质层，第二衬底，位于第二衬底上的至少第二电极，具有阴极和阳极，位于第二电极上的第二电介质层和位于第二电介质上的第二疏水层 层。 第一电极是锯齿形的，并且第二电极的阴极和阳极是梳状的并且彼此交错。

公开(公告)号：US06860157B1

公开(公告)日：2005-03-01

申请号：US10769627

申请日：2004-01-30

Applicant: Jing-Tang Yang ,  Wei-Chih Lin ,  Kuen-Jyh Tsai ,  Ker-Jer Huang

Inventor： Jing-Tang Yang ,  Wei-Chih Lin ,  Kuen-Jyh Tsai ,  Ker-Jer Huang

IPC: G01F1/19

CPC classification number: G01F1/3227 ,  Y10T137/224

Abstract: A fluidic oscillator includes an oscillator body having two attachment walls defining an oscillating chamber therebetween, an inlet duct communicatively extended from the oscillating chamber for guiding a flow of fluid entering into the oscillating chamber, an outlet duct communicatively extended from the oscillating chamber for guiding the flow of fluid exiting from the oscillating chamber, a flow splitter provided at the outlet duct to communicate with the oscillating chamber, and two feedback channels communicating with the oscillating chamber. Each of the attachment walls has an upstream portion and a downstream portion integrally extended therefrom as a step shouldering manner to form a modulating shoulder for modulating an oscillation of the flow within the oscillation chamber so as to stabilize the flow of the fluid to pass through the oscillator body.

Abstract translation: 流体振荡器包括：振荡器体，其具有在其间限定振荡室的两个连接壁，从振荡室通信地延伸的入口管，用于引导进入振荡室的流体流;从振荡室通信地延伸的出口管，用于引导 从振荡室流出的流体流，设置在出口管道处以与振荡室连通的分流器，以及与振荡室连通的两个反馈通道。 每个附接壁具有作为台阶承载方式一体地延伸的上游部分和下游部分，以形成用于调节振荡室内的流动的振荡的调制肩部，以便稳定流体流过 振荡器体。

公开(公告)号：US20060147741A1

公开(公告)日：2006-07-06

申请号：US11302818

申请日：2005-12-14

Applicant: Chien-Hung Ho ,  Sheng-Yuan Chen ,  Hsuan-Hsiu Hsu ,  Jing-Tang Yang ,  Chiko Chen

Inventor： Chien-Hung Ho ,  Sheng-Yuan Chen ,  Hsuan-Hsiu Hsu ,  Jing-Tang Yang ,  Chiko Chen

IPC: B22D7/00 ,  B32B3/10

CPC classification number: B32B3/10 ,  B32B3/26 ,  B32B3/266 ,  B32B2307/302 ,  B32B2457/00 ,  Y10T428/12 ,  Y10T428/24322

Abstract: The present invention provides a composite plate device for a thermal transpiration micropump apparatus. The provided composite plate device includes a substrate having a plurality of flow channels and a plurality of templates with closed sidewalls, wherein the plurality of flow channels allow fluid to flow therethrough and have a feature length larger than or equal to the mean free path length of the fluid. The provided composite plate device further includes a porous material that is filled in the plurality of templates of the substrate, wherein the porous material allows the fluid to flow therethrough and has an equivalent pore diameter smaller than or equal to the mean free path length of the fluid.

Abstract translation: 本发明提供一种用于热蒸发微型泵装置的复合板装置。 所提供的复合板装置包括具有多个流动通道的基板和具有封闭侧壁的多个模板，其中多个流动通道允许流体流过其中并具有大于或等于平均自由程长度的特征长度 流体。 提供的复合板装置还包括填充在基板的多个模板中的多孔材料，其中多孔材料允许流体流过其中，并且具有等于或等于平均自由程长度的当量孔径 流体。

公开(公告)号：US20050056569A1

公开(公告)日：2005-03-17

申请号：US10900649

申请日：2004-07-28

Applicant: Shih-Jun Yuan ,  Jing-Tang Yang ,  Jer-Liang Yeh ,  Chih-Sheng Yu ,  Yi-Chiuen Hu ,  Chien-Jen Chen

Inventor： Shih-Jun Yuan ,  Jing-Tang Yang ,  Jer-Liang Yeh ,  Chih-Sheng Yu ,  Yi-Chiuen Hu ,  Chien-Jen Chen

IPC: B03B7/00 ,  B04B5/10 ,  F04B17/00 ,  G01N33/543

CPC classification number: G01N27/745 ,  G01N33/5438 ,  Y10T436/11

Abstract: A detecting device for biochemical detections is provided. The detecting device includes a first substrate, a magnetic layer located on the first substrate, an isolation layer located on the magnetic layer, at least a first electrode located on the isolation layer, a first dielectric layer located on the first electrode, a first hydrophobic layer located on the first dielectric layer, a second substrate, at least a second electrode located on the second substrate and having a cathode and an anode, a second dielectric layer located on the second electrode and a second hydrophobic layer located on the second dielectric layer. The first electrode is zigzag-shaped, and the cathode and the anode of the second electrode are comb-shaped and interlaced with each other.

Abstract translation: 提供了用于生化检测的检测装置。 所述检测装置包括第一基板，位于所述第一基板上的磁性层，位于所述磁性层上的隔离层，位于所述隔离层上的至少第一电极，位于所述第一电极上的第一电介质层， 层，位于第一电介质层上的第二电介质层，第二衬底，位于第二衬底上并具有阴极和阳极的至少第二电极，位于第二电极上的第二电介质层和位于第二电介质层上的第二疏水层 。 第一电极是锯齿形的，并且第二电极的阴极和阳极是梳状的并且彼此交错。

公开(公告)号：US20050036908A1

公开(公告)日：2005-02-17

申请号：US10917762

申请日：2004-08-13

Applicant: Chih-Sheng Yu ,  Yi-Chiuen Hu ,  Ming-Yu Lin ,  Hsiao-Yu Chou ,  Chien-Jen Chen ,  Shih-Jun Yuan ,  Jing-Tang Yang

Inventor： Chih-Sheng Yu ,  Yi-Chiuen Hu ,  Ming-Yu Lin ,  Hsiao-Yu Chou ,  Chien-Jen Chen ,  Shih-Jun Yuan ,  Jing-Tang Yang

IPC: G01N21/64 ,  G01N33/543 ,  G01N21/00

CPC classification number: G01N21/6428 ,  G01N33/54326 ,  G01N2021/6439

Abstract: A biochemical detecting device for separating a reagent, a plurality of magnetic beads and a target from a mixture, and detecting the target is provided. The biochemical detecting device includes a first substrate, at least two first electrode sets located on the first substrate, a second electrode set located on the first substrate and between the two first electrode sets, and a second substrate covering the first substrate, each of the first electrode sets and the second electrode set. Accordingly, the movement of the mixture is digitally controlled by the provided biological detecting device.

Abstract translation: 提供了用于从混合物中分离试剂，多个磁珠和目标物以及检测靶的生化检测装置。 生化检测装置包括第一基板，位于第一基板上的至少两个第一电极组，位于第一基板上并位于两个第一电极组之间的第二电极组，以及覆盖第一基板的第二基板， 第一电极组和第二电极组。 因此，混合物的移动由所提供的生物检测装置进行数字控制。

公开(公告)号：US07794136B2

公开(公告)日：2010-09-14

申请号：US11429972

申请日：2006-05-09

Applicant: Jing-Tang Yang ,  Kai-Yang Tung ,  Wei-Feng Fang ,  Ker-Jer Huang

Inventor： Jing-Tang Yang ,  Kai-Yang Tung ,  Wei-Feng Fang ,  Ker-Jer Huang

IPC: B01F5/06

CPC classification number: B01F13/0059 ,  B01F5/061 ,  B01F2005/0621 ,  B01F2005/0636 ,  Y10S366/03

Abstract: The present invention discloses a vortex-modulation based micromixer for enforced mass exchange. The micromixer of the present invention comprises a mixing chamber with grooves on one wall thereof and a special-shape barrier on another wall. As different fluids are injected into the mixing chamber respectively from two inlets of the micromixer, the grooves and barriers of the micromixer of the present invention create the constructive interferences to form the active-like agitation of the fluid. For every groove, the flux passed by can be increased via its high pressure gradient. Understandably, the mixing efficiency of the fluids can be greatly improved within a very short distance. At last, the outlet of the micromixer is located in the downstream of the mixing chamber and further is able to connect with other elements. The present invention is entirely a passive micromixer and no additional energy is required. The present invention can apply to a continuous chemical analysis, particularly to a lab-on-a-chip or a micro total analysis system.

Abstract translation: 本发明公开了一种用于强制质量交换的基于涡旋调制的微混合器。 本发明的微混合器包括在其一个壁上具有凹槽的混合室和在另一壁上的特殊形状的阻挡层。 由于不同的流体分别从微型混合器的两个入口注入到混合室中，本发明的微混合器的凹槽和屏障产生了建立性的干扰以形成流体的活性样搅拌。 对于每个槽，可以通过其高压梯度来增加通过的通量。 可以理解，在非常短的距离内可以大大提高流体的混合效率。 最后，微混合器的出口位于混合室的下游，并且还能够与其他元件连接。 本发明完全是无源微混合器，并且不需要额外的能量。 本发明可以应用于连续化学分析，特别是对于芯片实验室或微型总分析系统。

公开(公告)号：US20080115849A1

公开(公告)日：2008-05-22

申请号：US11603030

申请日：2006-11-22

Applicant: Jing-Tang Yang ,  Chi-Ko Chen ,  Kun-Chih Tsai

Inventor： Jing-Tang Yang ,  Chi-Ko Chen ,  Kun-Chih Tsai

IPC: F15C1/06

CPC classification number: F15C1/22 ,  Y10T137/2224 ,  Y10T137/2229

Abstract: A micro-fluidic oscillator comprises a main body and a cover body for covering the main body. An oscillation chamber is disposed on the main body to provide an oscillation space for fluid. A sudden-expansion micro-nozzle is connected with one end of the oscillation chamber, and an outlet passage is connected with the other end of the oscillation chamber. Two fluid-separating bodies are located at the connection positions of the outlet passage and the oscillation chamber, respectively. Two feedback channels are located outside two attachment walls. The sudden-expansion micro-nozzle is used to break the viscous shear stress between fluid and the walls and to generate unstable flow and oscillation. Moreover, the two feedback channels have different lengths, inside diameters and alternate outlet positions to further enhance the oscillation of fluid.

Abstract translation: 微流体振荡器包括主体和用于覆盖主体的盖体。 振荡室设置在主体上，为流体提供振荡空间。 突然膨胀的微型喷嘴与振荡室的一端连接，出口通道与振荡室的另一端连接。 两个流体分离体分别位于出口通道和振荡室的连接位置。 两个反馈通道位于两个附件墙外。 突然膨胀的微型喷嘴用于破坏流体和壁之间的粘性剪切应力，并产生不稳定的流动和振荡。 此外，两个反馈通道具有不同的长度，内径和替代的出口位置，以进一步增强流体的振荡。

公开(公告)号：US20060285433A1

公开(公告)日：2006-12-21

申请号：US11155635

申请日：2005-06-20

Applicant: Jing-Tang Yang ,  Kuo-Wei Lin

Inventor： Jing-Tang Yang ,  Kuo-Wei Lin

IPC: B01F5/02 ,  B81B1/00

CPC classification number: B01F13/0059 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/0655 ,  B81B2201/051

Abstract: The present invention discloses a fluidic mixer of serpentine channel incorporated with staggered sudden-expansion and convergent cross sections, which comprises a flat cover and a channel body. The channel body further comprises two L-type mixer inlets, a mixing channel, and two L-type mixer outlets. The configuration of the mixing channel is a single serpentine channel incorporated with staggered sudden-expansion and convergent cross sections, wherein the serpentine structure and the sudden-expansion cross sections induces split flows, which further enable the fluid to stretch and fold so that the contact area within the fluid can be increased. The convergence after sudden expansion in cross section is to prepare the next action of sudden expansion, and such an iterative structure can obviously enhance the mixing effect. The present invention has the following characteristics: planar structure, which enables the measurement and fabrication, particularly the fabrication of micro mixing channel, to be easily undertaken; L-type mixer inlets and outlets, which enables the connection between the mixing channel and external channels to be robust so that the linkage and encapsulation of the micro mixing channel will be advantaged thereby; single-channel design, which enables the flow resistance not to increase owing to the mixing action, and which also enables the working fluid to be able to involve two-phase fluids containing suspension solid particles; low pressure drop; and no bulb residence inside the mixing channel.

Abstract translation: 本发明公开了一种具有交错的突然膨胀和会聚横截面的蛇形通道的流体混合器，其包括平的盖和通道体。 通道体还包括两个L型混合器入口，混合通道和两个L型混合器出口。 混合通道的构造是单一的蛇形通道，并入有交错的突然膨胀和会聚横截面，其中蛇形结构和突然膨胀横截面引起分流，这进一步使得流体能够拉伸和折叠，使得接触 流体内的区域可以增加。 横截面突然膨胀后的收敛是准备下一次突然膨胀的动作，这种迭代结构可以显着提高混合效果。 本发明具有以下特征：能够容易地进行测量和制造，特别是微混合通道的制造的平面结构; L型混合器入口和出口，其使得混合通道和外部通道之间的连接是稳固的，从而有利于微混合通道的连接和封装; 单通道设计，这使得流动阻力由于混合作用而不会增加，并且还使得工作流体能够涉及含有悬浮固体颗粒的两相流体; 低压降 混合通道内没有灯泡。

公开(公告)号：US20050232076A1

公开(公告)日：2005-10-20

申请号：US11107775

申请日：2005-04-18

Applicant: Jing-Tang Yang ,  Lilin Wang ,  Ker-Jer Huang

Inventor： Jing-Tang Yang ,  Lilin Wang ,  Ker-Jer Huang

IPC: B01F3/00 ,  B01F5/06 ,  B01F13/00 ,  B81B1/00

CPC classification number: B01F13/0059 ,  B01F5/061 ,  B01F2005/0621 ,  B01F2005/0636

Abstract: The micromixer with overlapping-crisscross entrance incorporated with the grooved microchannel, is used effectively for mixing two or more fluid streams. The X-shape overlapping-crisscross inlet ports wherein two microfluidic channels contact over a small area, allow the fluid streams flow through and create the tumbling inside the micromixer. Then merging with some patterned grooves on the walls also induces swirling motion. As a result, the folding and stretching effects of the flow are augmented to amplify the fluid mixing of two or more streams of the inlet fluids within a relative short distance in the micromixer. All of the flow streams are actuated with either pressure driven by a syringe pump or capillary electrophoresis. The present invention is applicable for micro total analysis systems and drug delivery systems.

Abstract translation: 具有与沟槽微通道结合的交叠十字交叉入口的微混合器被有效地用于混合两个或更多个流体流。 X形交叠十字交叉入口，其中两个微流体通道在小区域上接触，允许流体流流过并在微型混合器内部产生翻转。 然后与壁上的一些图案化凹槽合并也引起旋转运动。 结果，增加了流动的折叠和拉伸效果，以在微型混合器内相对较短的距离内放大入口流体的两个或更多个流体的流体混合。 所有的流动流由用注射器泵或毛细管电泳驱动的压力致动。 本发明适用于微量总分析系统和药物递送系统。

公开(公告)号：US20050045238A1

公开(公告)日：2005-03-03

申请号：US10926976

申请日：2004-08-27

Applicant: Jing-Tang Yang ,  Jia-Hui Chen ,  Ker-Jer Huang ,  Alex Chen

Inventor： Jing-Tang Yang ,  Jia-Hui Chen ,  Ker-Jer Huang ,  Alex Chen

IPC: F15C5/00 ,  F16K99/00 ,  F15C1/06

CPC classification number: F16K99/0001 ,  F15C5/00 ,  F16K99/0017 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0084 ,  Y10T137/2224

Abstract: The present invention discloses a novel micro valve device, comprising a micro fluidic channel, which is formed by combining two hydrophobic plates, and the micro/nano structure on the wall surfaces of the channel are used to manipulate the mobility of the fluid in the channel. The function of the micro/nano structure mentioned above is to alter the micro or nano surface pattern on the wall surfaces of the channel. According to the relation between the surface pattern and the surface tension, the textured areas on the wall surfaces can change the mobility of the fluid in the channel. This effect is used as a switch in new types of micro valve devices for biomedical tests. Methods of making the micro valve device are described and include generating a micro/nano structure on the surfaces of the channel. The temporal control of different valve resistances can be achieved with different lengths, shapes, depths and materials of the micro/nano structures.

Abstract translation: 本发明公开了一种新颖的微阀装置，其包括通过组合两个疏水板形成的微流体通道，并且通道的壁表面上的微/纳米结构用于操纵流体在通道中的流动性 。 上述微/纳米结构的功能是改变通道壁表面上的微观或纳米表面图案。 根据表面图案和表面张力之间的关系，壁表面上的纹理化区域可以改变通道中流体的流动性。 这种效应用作用于生物医学测试的新型微型阀装置中的开关。 描述制造微型阀装置的方法，包括在通道的表面上产生微/纳米结构。 可以通过微/纳米结构的不同长度，形状，深度和材料实现不同阀阻的时间控制。