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    Bioabsorbable composites of derivatized hyaluronic acid and other biodegradable, biocompatible polymers
    2.
    发明授权
    Bioabsorbable composites of derivatized hyaluronic acid and other biodegradable, biocompatible polymers 有权

    公开(公告)号：US06548081B2

    公开(公告)日：2003-04-15

    申请号：US09863029

    申请日：2001-05-22

    Applicant: Khalid K. Sadozai ,  Jing-wen Kuo ,  Charles H. Sherwood

    Inventor： Khalid K. Sadozai ,  Jing-wen Kuo ,  Charles H. Sherwood

    IPC: A61F202

    CPC classification number: C08B37/0072 ,  A61K47/61 ,  A61L31/10 ,  A61L31/129 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  C08L5/08

    Abstract: The present invention relates to a composite and a method for reducing post-operative adhesion of tissues. The composite includes a biocompatible, biodegradable support, and a water-insoluble hyaluronic acid derivative at the support. The hyaluronic acid derivative includes an N-acylurea that results from cross-linking by the reaction of hyaluronic acid with a multifunctional carbodiimide. Optionally, a monocarbodiimide also may be employed. A pharmaceutically-active molecule may be added to the N-acylurea derivative of hyaluronic acid. Although the composite includes material that prevents adhesion between tissues, in order to reduce the need for suturing when the composite is being used during a surgical procedure, a material that enhances adhesion of the composite to tissues may be applied to a surface of the composite. A method of forming the composite for reducing post-operative adhesion of tissues, including the step of applying an N-acylurea derivative of hyaluronic acid resulting from cross-linking with a multifunctional carbodiimide, to a biocompatible, biodegradable support; a method of preparing a drug delivery vehicle that includes a pharmaceutically-active molecule with the N-acylurea derivative of hyaluronic acid resulting from cross-linking with a multifunctional carbodiimide; and a method of reducing post-operative adhesion of tissues are disclosed.

    Steam-sterilizing solid hyaluronic acid
    7.
    发明授权
    Steam-sterilizing solid hyaluronic acid 失效
    蒸汽灭菌固体透明质酸

    公开(公告)号：US5621093A

    公开(公告)日：1997-04-15

    申请号：US468262

    申请日：1995-06-06

    Applicant: David A. Swann ,  Jing-wen Kuo ,  Vladimir Pinsky

    Inventor： David A. Swann ,  Jing-wen Kuo ,  Vladimir Pinsky

    IPC: C08B37/08 ,  C07H5/06 ,  C07H1/06 ,  C07H13/02

    CPC classification number: C08B37/0072

    Abstract: A method for sterilizing solid hyaluronic acid includes autoclaving solid hyaluronic acid, whereby the solid hyaluronic acid is exposed to saturated steam at positive gauge pressure for a period of time that is sufficient to sterilize the solid hyaluronic acid. In one embodiment, autoclaving includes exposing the solid hyaluronic acid to saturated steam at a gauge pressure of about one atmosphere for a period of time between about fifteen and thirty minutes.

    Abstract translation: 用于灭菌固体透明质酸的方法包括高压灭菌固体透明质酸，由此固体透明质酸暴露于正表压下的饱和蒸汽一段足以对固体透明质酸进行灭菌的时间。 在一个实施方案中，高压灭菌包括将固体透明质酸暴露于大约一个大气压的表压下的饱和蒸汽约15至30分钟之间的时间。

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