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    MULTIFUNCTIONAL RESTRICTIVE VALVE
    2.
    发明申请
    MULTIFUNCTIONAL RESTRICTIVE VALVE 有权
    多功能限位阀

    公开(公告)号：US20110079296A1

    公开(公告)日：2011-04-07

    申请号：US12966471

    申请日：2010-12-13

    Applicant: Michael Brown ,  John Lockhart ,  Jeffrey S. Doss

    Inventor： Michael Brown ,  John Lockhart ,  Jeffrey S. Doss

    IPC: F16K17/36

    CPC classification number: F16K31/002 ,  E03C1/04 ,  E03C1/0408 ,  E03C1/044 ,  E03C2001/0418 ,  F16K1/123 ,  F16K3/24 ,  G05D23/022 ,  Y02A20/414 ,  Y10T137/7737

    Abstract: A multifunctional restrictive valve for controlling the flow of water therethrough. The valve has a main body with a flow channel through the main body. The main body receives water upstream thereof through an inlet port and passes it out through an outlet port at the downstream end of the body. A flow control assembly is located in the flow channel and includes a temperature sensor/actuator acting on a piston to move, when the temperature sensor heats up the piston, to block water flow control ports. The flow control assembly also includes an override feature wherein the piston is located within a slide and the flow control ports are located in the slide. By moving the slide away from the piston when the piston is blocking the flow control ports, the temperature sensor and piston may be overridden and flow may resume through the main body.

    Abstract translation: 一种用于控制水流通过的多功能限制阀。 该阀具有通过主体的流动通道的主体。 主体通过入口接收其上游的水，并通过身体下游端的出口将其排出。 流量控制组件位于流动通道中，并且当温度传感器加热活塞时，包括作用在活塞上的温度传感器/致动器以阻挡水流控制端口。 流量控制组件还包括超控特征，其中活塞位于滑块内，并且流量控制端口位于滑块中。 当活塞阻塞流量控制端口时，通过将滑块从活塞移开，可能会覆盖温度传感器和活塞，并可通过主体恢复流量。

    Pharmaceutical composition for delayed hypersensitivity
    3.
    发明申请
    Pharmaceutical composition for delayed hypersensitivity 审中-公开
    用于延迟超敏反应的药物组合物

    公开(公告)号：US20060183664A1

    公开(公告)日：2006-08-17

    申请号：US10496851

    申请日：2002-12-13

    Applicant: Toshiaki Takizawa ,  Masaki Tamiya ,  Naohiro Saito ,  Toru Kanke ,  Jiro Matsumoto ,  Yasushi Wada ,  Junichi Kawagoe ,  William Ferrell ,  John Lockhart

    Inventor： Toshiaki Takizawa ,  Masaki Tamiya ,  Naohiro Saito ,  Toru Kanke ,  Jiro Matsumoto ,  Yasushi Wada ,  Junichi Kawagoe ,  William Ferrell ,  John Lockhart

    IPC: A61K38/54

    CPC classification number: A61K45/06 ,  A61K31/00 ,  Y02A50/423 ,  A61K2300/00

    Abstract: The present invention provides a pharmaceutical composition by a novel action mechanism without serious side effects for delayed hypersensitivity and a screening method of the same. The invention also provides a novel assay method of inhibitors/suppressive agents of PAR-2. The invention relates to a pharmaceutical composition for delayed hypersensitivity containing one or two or more active ingredients selected from the group consisting of inhibitors of PAR-2 and suppressive agents of PAR-2 gene expression and a pharmaceutically acceptable carrier, and to a method for screening active ingredients for pharmaceutical composition for delayed hypersensitivity by contacting a subject substance with cells expressing PAR-2 and by determining expression or activity of PAR-2. The invention also relates to a method for detecting or quantifying actions of the subject substance for PAR-2 using cells expressing PAR-2 in a culture containing inositol.

    Abstract translation: 本发明通过新颖的作用机理提供药物组合物，对迟发性超敏反应没有严重的副作用及其筛选方法。 本发明还提供了PAR-2抑制剂/抑制剂的新型测定方法。 本发明涉及一种用于延迟超敏反应的药物组合物，其含有选自PAR-2的抑制剂和PAR-2基因表达的抑制剂的一种或两种以上活性成分和药学上可接受的载体，以及筛选方法 通过使受试物质与表达PAR-2的细胞接触并通过测定PAR-2的表达或活性来延迟超敏反应的药物组合物的活性成分。 本发明还涉及使用含有肌醇的培养物中表达PAR-2的细胞检测或定量PAR-2的物质的作用的方法。

    3-STAGE TEMPERATURE CONTROL VALVE
    5.
    发明申请
    3-STAGE TEMPERATURE CONTROL VALVE 有权
    3级温度控制阀

    公开(公告)号：US20110180741A1

    公开(公告)日：2011-07-28

    申请号：US12807719

    申请日：2010-09-13

    Applicant: John Lockhart

    Inventor： John Lockhart

    IPC: F16K1/00

    CPC classification number: G05D23/022 ,  E03C1/0408 ,  E03C2001/0418 ,  F16K31/002

    Abstract: A temperature control valve that effectively manages fluid pressure therethrough, including pressure differentials which may exist therein, such as from the upstream port to the downstream port, and about a piston slidingly disposed therewithin proximate a fluid flow path. In one embodiment a 3 stage valve is provided whereby fluid flows therethrough when the piston is in a first position, fluid flow is inhibited in a second piston position, and an override third position whereby fluid flows therethrough. When the piston is in the second position, the fluid pressure differential across the piston is balanced and an axial spring force on the piston is relatively small, thereby reducing any subsequent axial force required to advance the piston to the third free flow position, and allowing the valve to be comprised of cheaper materials including plastic.

    Abstract translation: 一种温度控制阀，其有效地管理其中的流体压力，包括其中可能存在的压力差，例如从上游端口到下游端口，以及围绕在靠近流体流动路径滑动地设置的活塞。 在一个实施例中，提供了三级阀，当活塞处于第一位置时，流体流过其中，在第二活塞位置阻止流体流动，并且由此流体流过其中的超控位置。 当活塞处于第二位置时，活塞两端的流体压差平衡，并且活塞上的轴向弹簧力相对较小，从而减少将活塞推进到第三自由流动位置所需的任何随后的轴向力，并允许 阀门由包括塑料在内的便宜材料组成。

    SYSTEM AND METHOD FOR GRAPHICALLY CONFIGURING LEADS
    8.
    发明申请
    SYSTEM AND METHOD FOR GRAPHICALLY CONFIGURING LEADS 有权
    用于图形配置的系统和方法

    公开(公告)号：US20070213797A1

    公开(公告)日：2007-09-13

    申请号：US11749890

    申请日：2007-05-17

    Applicant: Par Lindh ,  James Kalgren ,  Rene Wentkowski ,  John Lockhart

    Inventor： Par Lindh ,  James Kalgren ,  Rene Wentkowski ,  John Lockhart

    IPC: A61N1/05

    CPC classification number: A61N1/37264 ,  A61N1/0563 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/37247 ,  A61N1/3962 ,  A61N1/3993 ,  A61N2001/0585 ,  Y10S128/92 ,  Y10S128/922 ,  Y10S128/923

    Abstract: Systems and methods are provided for graphically configuring leads for a medical device. According to one aspect, the system generally comprises a medical device and a processing device, such as a programmer or computer, adapted to be in communication with the medical device. The medical device has at least one lead with at least one electrode in a configuration that can be changed using the processing device. The processing device provides a graphical display of the configuration, including a representative image of a proposed electrical signal to be applied by the medical device between the at least one electrode of the medical device and at least one other electrode before the medical device applies the electrical signal between the at least one electrode and the at least one other electrode. In one embodiment, the graphical display graphically represents the lead(s), the electrode(s), a pulse polarity, and a vector.

    Abstract translation: 提供了用于图形化配置医疗设备引线的系统和方法。 根据一个方面，系统通常包括医疗设备和适于与医疗设备通信的诸如编程器或计算机的处理设备。 医疗装置具有至少一个引线，其中至少一个电极可以使用该处理装置进行改变。 所述处理装置提供所述配置的图形显示，其包括所述医疗装置在所述医疗装置的所述至少一个电极与所述至少一个其它电极之间施加的所提出的电信号的代表性图像， 信号在所述至少一个电极和所述至少一个其它电极之间。 在一个实施例中，图形显示图形地表示引线，电极，脉冲极性和矢量。

    System and method for graphically configuring leads
    10.
    发明授权
    System and method for graphically configuring leads 有权
    用于图形化配置引线的系统和方法

    公开(公告)号：US08571660B2

    公开(公告)日：2013-10-29

    申请号：US13177000

    申请日：2011-07-06

    Applicant: Par Lindh ,  James Kalgren ,  Rene H. Wentkowski ,  John Lockhart

    Inventor： Par Lindh ,  James Kalgren ,  Rene H. Wentkowski ,  John Lockhart

    IPC: A61N1/39

    CPC classification number: A61N1/37264 ,  A61N1/0563 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/37247 ,  A61N1/3962 ,  A61N1/3993 ,  A61N2001/0585 ,  Y10S128/92 ,  Y10S128/922 ,  Y10S128/923

    Abstract: Systems and methods are provided for graphically configuring leads for a medical device. According to one aspect, the system generally comprises a medical device and a processing device, such as a programmer or computer, adapted to be in communication with the medical device. The medical device has at least one lead with at least one electrode in a configuration that can be changed using the processing device. The processing device provides a graphical display of the configuration, including a representative image of a proposed electrical signal to be applied by the medical device between the at least one electrode of the medical device and at least one other electrode before the medical device applies the electrical signal between the at least one electrode and the at least one other electrode. In one embodiment, the graphical display graphically represents the lead(s), the electrode(s), a pulse polarity, and a vector.

    Abstract translation: 提供了用于图形化配置医疗设备引线的系统和方法。 根据一个方面，系统通常包括医疗设备和适于与医疗设备通信的诸如编程器或计算机的处理设备。 医疗装置具有至少一个引线，其中至少一个电极可以使用该处理装置进行改变。 所述处理装置提供所述配置的图形显示，其包括所述医疗装置在所述医疗装置的所述至少一个电极与所述至少一个其它电极之间施加的所提出的电信号的代表性图像， 信号在所述至少一个电极和所述至少一个其它电极之间。 在一个实施例中，图形显示图形地表示引线，电极，脉冲极性和矢量。

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