公开(公告)号：US09255130B2

公开(公告)日：2016-02-09

申请号：US13056975

申请日：2009-07-29

Applicant: John Yu ,  Alice Yu ,  Ming-Wei Kuo ,  Jui-Chin Chang

Inventor： John Yu ,  Alice Yu ,  Ming-Wei Kuo ,  Jui-Chin Chang

IPC: A61K48/00 ,  C07K14/47 ,  C07K16/18 ,  C12N15/113 ,  C12Q1/68 ,  G01N33/68

CPC classification number: C07K14/4747 ,  A61K48/005 ,  C07K16/18 ,  C12N15/113 ,  C12N2799/025 ,  C12Q1/6876 ,  G01N33/6854

Abstract: Methods and compositions for treating retinal diseases comprising therapeutic amounts of a compound selected from a normal Puf-A gene product, an active polypeptide fragment thereof, an analog thereof or a peptidomimetic thereof. Vectors, including AAV vectors comprising the therapeutic compound are provided. Puf-A compositions suitable for subretinal, intravitreal, topical, subconjunctival, retrobulbar, periocular, suprachoroidal, or intraocular administration are provided. Methods for screening siRNA, RNAi and shRNA, small molecules and monoclonal antibodies that inhibit Puf-A target activity and reduce apoptosis are provided.

Abstract translation: 用于治疗视网膜疾病的方法和组合物包括治疗量的选自正常Puf-A基因产物，其活性多肽片段，其类似物或肽模拟物的化合物。 提供载体，包括包含治疗化合物的AAV载体。 提供适用于视网膜下，玻璃体内，局部，结膜下结膜，球后，眼周，脉络膜或眼内给药的Puf-A组合物。 提供了筛选siRNA，RNAi和shRNA，抑制Puf-A靶活性和减少细胞凋亡的小分子和单克隆抗体的方法。

公开(公告)号：US20130202678A1

公开(公告)日：2013-08-08

申请号：US13056975

申请日：2008-07-29

Applicant: John Yu ,  Alice Yu ,  Ming-Wei Kuo ,  Jui-Chin Chang

Inventor： John Yu ,  Alice Yu ,  Ming-Wei Kuo ,  Jui-Chin Chang

IPC: C07K14/47 ,  G01N33/68 ,  C12Q1/68 ,  C12N15/113 ,  C07K16/18

CPC classification number: C07K14/4747 ,  A61K48/005 ,  C07K16/18 ,  C12N15/113 ,  C12N2799/025 ,  C12Q1/6876 ,  G01N33/6854

Abstract: Methods and compositions for treating retinal diseases comprising therapeutic amounts of a compound selected from a normal Puf-A gene product, an active polypeptide fragment thereof, an analog thereof or a peptidomimetic thereof. Vectors, including AAV vectors comprising the therapeutic compound are provided. Puf-A compositions suitable for subretinal, intravitreal, topical, subconjunctival, retrobulbar, periocular, suprachoroidal, or intraocular administration are provided. Methods for screening siRNA, RNAi and shRNA, small molecules and monoclonal antibodies that inhibit Puf-A target activity and reduce apoptosis are provided.

Abstract translation: 用于治疗视网膜疾病的方法和组合物包括治疗量的选自正常Puf-A基因产物，其活性多肽片段，其类似物或肽模拟物的化合物。 提供载体，包括包含治疗化合物的AAV载体。 提供适用于视网膜下，玻璃体内，局部，结膜下结膜，球后，眼周，脉络膜或眼内给药的Puf-A组合物。 提供了筛选siRNA，RNAi和shRNA，抑制Puf-A靶活性和减少细胞凋亡的小分子和单克隆抗体的方法。

公开(公告)号：US06397377B1

公开(公告)日：2002-05-28

申请号：US09414899

申请日：1999-10-08

Applicant: Bing-Ying Wang ,  Chun-Yi Yang ,  Chun-Jung Lin ,  Jui-Chin Chang ,  Mam-Tsung Wang

Inventor： Bing-Ying Wang ,  Chun-Yi Yang ,  Chun-Jung Lin ,  Jui-Chin Chang ,  Mam-Tsung Wang

IPC: G06F1750

CPC classification number: G03F1/36

Abstract: The present invention provides a method of performing optical proximity corrections of a photo mask pattern by using a computer. The photo mask pattern is formed on a photo mask which is used when performing photolithography for forming a predetermined original pattern by exposing a photo-resist layer in a predetermined area of a semiconductor wafer. The photo mask pattern is divided into a plurality of rectangular blocks. Each block can be bright or dark, and a least one side and two corners of the block are shared with another block. Each of shared corners is checked to find corners which may be affected by an optic proximity effect, and those corners are modified so as to prevent them from being affected by the optic proximity effect.

Abstract translation: 本发明提供一种通过使用计算机执行光掩模图案的光学邻近校正的方法。 光掩模图案形成在通过在半导体晶片的预定区域中曝光光刻胶层进行光刻以形成预定原始图案时使用的光掩模上。 光掩模图案被分成多个矩形块。 每个块可以是明亮的或暗的，并且该块的至少一个侧面和两个角与另一个块共享。 检查每个共享拐角以找到可能受光学邻近效应影响的角部，并且修改这些拐角以防止它们受到光学邻近效应的影响。

公开(公告)号：US6166943A

公开(公告)日：2000-12-26

申请号：US421260

申请日：1999-10-20

Applicant: Ping-Ying Wang ,  Chun-Yi Yang ,  Chun-Jung Lin ,  Jui-Chin Chang ,  Mam-Tsung Wang

Inventor： Ping-Ying Wang ,  Chun-Yi Yang ,  Chun-Jung Lin ,  Jui-Chin Chang ,  Mam-Tsung Wang

IPC: G11C17/10 ,  G11C17/00

CPC classification number: G11C17/10

Abstract: The present invention provides a method of writing a set of binary codes into a ROM. The method is performed by forming a first photo mask and a second photo mask according to an original first code pattern, an original second code pattern, and a set of binary codes to be written into the ROM. Final first and second code patterns are formed by coupling the binary codes to be written with the original first and second code patterns by using a Boolean logical OR operation. The first and second photo masks are formed according to the final first and second code patterns. The first photolithographic process is performed using the first photo mask, and the first ion implantation process is performed; the second photolithographic process is performed using the second photo mask, and the second ion implantation process is performed. Thus the set of binary codes is written into the ROM completely and correctly.

Abstract translation: 本发明提供了将一组二进制码写入到ROM中的方法。 该方法通过根据原始第一代码图案，原始第二代码图案和要写入ROM的一组二进制代码形成第一光掩模和第二光掩模来执行。 最终的第一和第二代码模式通过使用布尔逻辑“或”运算来耦合待写入的二进制代码与原始的第一和第二代码模式而形成。 根据最终的第一和第二编码模式形成第一和第二光掩膜。 使用第一光掩模执行第一光刻工艺，并且执行第一离子注入工艺; 使用第二光掩模进行第二光刻工序，进行第二离子注入工序。 因此，二进制代码集完全正确地写入ROM中。