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公开(公告)号：US20120157443A1
公开(公告)日：2012-06-21
申请号：US13393192
申请日：2010-09-03
Applicant: Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
Inventor： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC: A61K31/553 , C07D487/04 , A61K31/519 , C07D401/04 , A61K31/506 , C07D473/34 , A61K31/52 , C07D417/14 , C07D413/12 , C07D401/14 , A61K31/55 , A61P37/06 , A61P29/00 , A61P35/00 , A61P35/02 , C12N9/99
CPC classification number: C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
Abstract translation: 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。
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公开(公告)号：US08987284B2
公开(公告)日：2015-03-24
申请号：US13380808
申请日：2010-07-02
Applicant: Wang Shen , Aimin Zhang , Junfa Fan , Xiaoling Zheng
Inventor： Wang Shen , Aimin Zhang , Junfa Fan , Xiaoling Zheng
IPC: A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00 , C07F9/6512 , C07F9/6558 , C07F9/6568 , C07F9/6571
CPC classification number: C07F9/65685 , C07F9/65128 , C07F9/65586 , C07F9/657181
Abstract: Disclosed are novel quinazoline derivatives containing phosphorus substitutions and methods for the treatment of hyperproliferative diseases (e.g. cancer) using the compounds. These compounds are type I receptor protein kinase inhibitors useful in treating disorders related to abnormal protein kinase activities such as cancer and inflammation in mammals. Also disclosed are pharmaceutical compositions containing the compounds, methods for the preparation of the compounds and their pharmaceutically acceptable salts.
Abstract translation: 公开了含磷取代的新型喹唑啉衍生物和使用该化合物治疗过度增殖性疾病（例如癌症）的方法。 这些化合物是I型受体蛋白激酶抑制剂，可用于治疗与异常蛋白激酶活性相关的疾病，例如哺乳动物的癌症和炎症。 还公开了含有化合物的药物组合物，制备化合物的方法及其药学上可接受的盐。
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公开(公告)号：US20100311712A1
公开(公告)日：2010-12-09
申请号：US12778913
申请日：2010-05-12
Applicant: Xi CHEN , Dean R. DRAGOLI , Pingchen FAN , Mark M. GLEASON , Juan C. JAEN , Lianfa LI , Jeffrey P. MCMAHON , Jay POWERS , Yibin ZENG , Penglie ZHANG , Junfa FAN
Inventor： Xi CHEN , Dean R. DRAGOLI , Pingchen FAN , Mark M. GLEASON , Juan C. JAEN , Lianfa LI , Jeffrey P. MCMAHON , Jay POWERS , Yibin ZENG , Penglie ZHANG , Junfa FAN
IPC: A61K31/551 , C07D417/06 , C07D417/14 , A61P29/00 , A61P35/00 , A61P17/02 , C12N5/02
CPC classification number: C07D401/14 , C07D403/14 , C07D417/14
Abstract: Compounds having formula I, or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.
Abstract translation: 提供具有式I化合物或其药学上可接受的盐，水合物或N-氧化物，并且可用于结合CXCR7，并且治疗至少部分依赖于CXCR7活性的疾病。 因此，本发明还提供含有一种或多种上述化合物与药学上可接受的赋形剂混合的组合物。
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Patent Agency Ranking
公开(公告)号：US20120196833A1
公开(公告)日：2012-08-02
申请号：US13380808
申请日：2010-07-02
Applicant: Wang Shen , Aimin Zhang , Junfa Fan , Xiaoling Zheng
Inventor： Wang Shen , Aimin Zhang , Junfa Fan , Xiaoling Zheng
IPC: A61K31/675 , A61P35/00 , C07F9/6571 , C07F9/6584 , C07F9/655
CPC classification number: C07F9/65685 , C07F9/65128 , C07F9/65586 , C07F9/657181
Abstract: Disclosed are novel quinazoline derivatives containing phosphorus substitutions and methods for the treatment of hyperproliferative diseases (e.g. cancer) using the compounds. These compounds are type I receptor protein kinase inhibitors useful in treating disorders related to abnormal protein kinase activities such as cancer and inflammation in mammals. Also disclosed are pharmaceutical compositions containing the compounds, methods for the preparation of the compounds and their pharmaceutically acceptable salts.
Abstract translation: 公开了含磷取代的新型喹唑啉衍生物和使用该化合物治疗过度增殖性疾病（例如癌症）的方法。 这些化合物是I型受体蛋白激酶抑制剂，可用于治疗与异常蛋白激酶活性相关的疾病，例如哺乳动物的癌症和炎症。 还公开了含有化合物的药物组合物，制备化合物的方法及其药学上可接受的盐。
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公开(公告)号：US20120157442A1
公开(公告)日：2012-06-21
申请号：US13393191
申请日：2010-09-03
Applicant: Minna Bui , Patrick Conlon , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Alexey Ishchenko , Tracy J. Jenkins , Gnanasambandam Kumaravel , Doug Marcotte , Noel Powell , Daniel Scott , Art Taveras , Deping Wang , Min Zhong
Inventor： Minna Bui , Patrick Conlon , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Alexey Ishchenko , Tracy J. Jenkins , Gnanasambandam Kumaravel , Doug Marcotte , Noel Powell , Daniel Scott , Art Taveras , Deping Wang , Min Zhong
IPC: A61K31/553 , A61K31/519 , A61K31/5377 , C07D401/04 , A61K31/506 , A61P35/02 , A61K31/55 , C12N9/99 , A61P37/06 , A61P29/00 , A61P35/00 , C07D487/04 , C07D471/04
CPC classification number: C07D473/34 , C07D239/70 , C07D401/04 , C07D471/04 , C07D487/04
Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
Abstract translation: 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。
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公开(公告)号：US09029359B2
公开(公告)日：2015-05-12
申请号：US13393191
申请日：2010-09-03
Applicant: Minna Bui , Patrick Conlon , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Alexey Ishchenko , Tracy J. Jenkins , Gnanasambandam Kumaravel , Doug Marcotte , Noel Powell , Daniel Scott , Art Taveras , Deping Wang , Min Zhong
Inventor： Minna Bui , Patrick Conlon , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Alexey Ishchenko , Tracy J. Jenkins , Gnanasambandam Kumaravel , Doug Marcotte , Noel Powell , Daniel Scott , Art Taveras , Deping Wang , Min Zhong
IPC: C07D473/34 , C07D471/04 , C07D239/70 , C07D401/04 , C07D487/04
CPC classification number: C07D473/34 , C07D239/70 , C07D401/04 , C07D471/04 , C07D487/04
Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
Abstract translation: 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。
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公开(公告)号：US08853202B2
公开(公告)日：2014-10-07
申请号：US12778913
申请日：2010-05-12
Applicant: Xi Chen , Dean R. Dragoli , Pingchen Fan , Mark M. Gleason , Juan C. Jaen , Lianfa Li , Jeffrey P. McMahon , Jay Powers , Yibin Zeng , Penglie Zhang , Junfa Fan
Inventor： Xi Chen , Dean R. Dragoli , Pingchen Fan , Mark M. Gleason , Juan C. Jaen , Lianfa Li , Jeffrey P. McMahon , Jay Powers , Yibin Zeng , Penglie Zhang , Junfa Fan
IPC: A61K31/497 , A61P35/00 , A61P9/10 , C07D401/14 , C07D417/14 , C07D403/14
CPC classification number: C07D401/14 , C07D403/14 , C07D417/14
Abstract: Compounds having formula I, or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present invention provides in further aspects, compositions containing one or more of the above-noted compounds in admixture with a pharmaceutically acceptable excipient.
Abstract translation: 提供具有式I化合物或其药学上可接受的盐，水合物或N-氧化物，并且可用于结合CXCR7，并且治疗至少部分依赖于CXCR7活性的疾病。 因此，本发明还提供含有一种或多种上述化合物与药学上可接受的赋形剂混合的组合物。
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公开(公告)号：US08785440B2
公开(公告)日：2014-07-22
申请号：US13393192
申请日：2010-09-03
Applicant: Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
Inventor： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC: A61K31/535
CPC classification number: C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
Abstract translation: 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。
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