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    Cells or tissue coated with non-fibrogenic alginate less than 200 .mu.m thick
    6.
    发明授权
    Cells or tissue coated with non-fibrogenic alginate less than 200 .mu.m thick 失效
    用不超过200μm厚的非纤维形成藻酸盐涂覆的细胞或组织

    公开(公告)号：US5656468A

    公开(公告)日：1997-08-12

    申请号：US403348

    申请日：1995-03-14

    Applicant: Randel E. Dorian ,  Kent C. Cochrum

    Inventor： Randel E. Dorian ,  Kent C. Cochrum

    IPC: A61K9/16 ,  A61K35/12 ,  C12N5/00 ,  C12N5/071 ,  C12N11/04 ,  C12N11/10 ,  C12N11/00 ,  C12N13/00

    CPC classification number: C12N5/0012 ,  A61K9/1652 ,  A61K9/1694 ,  C12N11/04 ,  C12N5/0677 ,  A61K2035/128 ,  C12N2533/74

    Abstract: An electrostatic process is used for coating a biological material with a uniform, continuous polymer layer by discharging a suspension of the biological material in a gelable coating polymer solution in a continuous stream through an orifice into an electrostatic field. The stream is attenuated to form droplets by maintaining an electrostatic voltage between the needle and the gelling solution which is sufficient to maintain an attraction of at least 1.times.10.sup.-6 newtons on the stream of liquid leaving the needle, and the droplets are collected in a gelling solution. A preferred product is pancreatic islets having a continuous, smooth coating of high polymannuronate non-fibrogenic alginate having a thickness less than 200 .mu.m such as about 20-200 .mu.m. The alginate preferably contains less than 1 wt. % fucose, less than 0.5 wt. % sulfate and less than 0.01 wt. % phloroglucinol, is free of fibrinoogenic concentration of protein, and has a mannuronate to guluronate ratio of from 1.2 to 6. Preferably, the electrostatic field is formed by applying an electrostatic continuous DC voltage to each the needle and gelling solution so that the needle and solution have opposite charges.

    Abstract translation: 通过将连续流中的生物材料的悬浮液通过孔喷射到静电场中，将静电过程用于通过将生物材料的悬浮液排出到可凝胶涂层聚合物溶液中，以均匀连续的聚合物层来涂覆生物材料。 通过保持针和胶凝溶液之间的静电电压来使流减弱以形成液滴，其足以在离开针的液体流上保持至少1×10 -6牛顿的吸引力，并且将液滴收集在胶凝中 解。 优选的产品是具有厚度小于200μm（例如约20-200μm）的高聚甘露糖醛酸盐非纤维形成藻酸盐的连续光滑涂层的胰岛。 藻酸盐优选含有少于1wt。 ％岩藻糖，小于0.5wt。 ％硫酸盐和小于0.01重量％ ％的间苯三酚不含蛋白质的纤维蛋白原浓度，并且甘露糖醛酸盐与古洛糖酸的比例为1.2〜6。优选地，静电场是通过向针和胶凝溶液施加静电连续的直流电压形成的， 解决方案有相反的收费。

    Microcapsule generating system containing an air knife and method of encapsulating
    9.
    发明授权
    Microcapsule generating system containing an air knife and method of encapsulating 失效
    含有气刀的微胶囊生成系统及其封装方法

    公开(公告)号：US5521079A

    公开(公告)日：1996-05-28

    申请号：US185709

    申请日：1994-01-24

    Applicant: Randel E. Dorian ,  Kent C. Cochrum

    Inventor： Randel E. Dorian ,  Kent C. Cochrum

    IPC: A01N1/02 ,  A61K9/50 ,  A61K35/12 ,  B01J2/00 ,  B01J13/04 ,  C12M1/40 ,  C12M3/06 ,  C12N5/00 ,  C12N5/071 ,  C12N11/04 ,  C12N11/00 ,  C12N11/10

    CPC classification number: A01N1/0242 ,  A01N1/02 ,  A01N1/0231 ,  A61K9/5089 ,  B01J13/04 ,  B01J2/003 ,  C12M45/22 ,  C12N11/04 ,  C12N5/0012 ,  C12N5/0671 ,  C12N5/0677 ,  A61K2035/128 ,  C12N2533/74 ,  Y10T428/2984

    Abstract: Spherical microcapsules containing biological material such as tissue or living cells are formed with a diameter of less than 300 .mu.m using a microcapsule generating system containing an air knife. The air knife is formed by an air sleeve positioned eccentrically around a needle. An encapsulating material such as an alginate solution containing the biological material to be encapsulated is forced through the needle, while pressurized air is introduced into the air sleeve and flows out an end opening of the sleeve in which the needle is positioned. The pressurized air breaks up the alginate being discharged from the needle. The resultant alginate droplets fall into a collecting tank where they contact a gelling medium, such as CaCl.sub.2, so that the outer surface of these droplets harden and microcapsules are formed. In addition to being eccentrically positioned to facilitate very small droplet formation, the needle preferably has a beveled, pointed discharge end surface to enhance droplet size reduction. The beveled end surface of the needle preferably extends beyond the end opening of the sleeve and is positioned facing the center of the air sleeve. The end opening of the air sleeve may also be beveled.

    Abstract translation: 使用包含气刀的微胶囊生成系统，使用含有小于300μm的直径的生物材料如组织或活细胞的球形微胶囊。 气刀由围绕针定位的空气套筒形成。 将包含待包封的生物材料的藻酸盐溶液的包封材料强制通过针，同时加压的空气被引入空气套筒中并流出针定位在其中的套筒的端部开口。 加压空气破坏从针排出的藻酸盐。 所得的藻酸盐液滴落入收集罐中，在其中它们接触诸如CaCl 2的胶凝介质，使得这些液滴的外表面变硬并形成微胶囊。 除了偏心地定位以促进非常小的液滴形成之外，针优选地具有倾斜的尖端的排出端面，以增强液滴尺寸的减小。 针的倾斜端面优选地延伸超出套筒的端部开口并且面向空气套筒的中心定位。 空气套筒的端部开口也可以是斜面的。

    Coated transplants and method for making same
    10.
    发明授权
    Coated transplants and method for making same 失效
    涂层移植物及其制备方法

    公开(公告)号：US4696286A

    公开(公告)日：1987-09-29

    申请号：US866167

    申请日：1986-05-22

    Applicant: Kent C. Cochrum

    Inventor： Kent C. Cochrum

    IPC: A01N1/02 ,  A61F2/02 ,  A61K9/16 ,  A61K9/50 ,  A61K35/12 ,  A61K35/39 ,  A61L27/34 ,  A61B19/00

    CPC classification number: A61K9/5073 ,  A61F2/022 ,  A61K9/1611 ,  A61K9/5031 ,  A61L27/34 ,  Y10S930/29

    Abstract: Transplants, such as pancreatic islets, are made suitable for transplantation into a genetically dissimilar individual by coating the transplant with a surface-conforming bonding bridge layer of a multifunctional material that binds chemically to a surface component of the transplant followed by a semipermeable, biologically compatible layer of a polymer that binds chemically to the bonding bridge layer.

    Abstract translation: 移植物，例如胰岛，适合于移植到遗传上不同的个体中，通过用表面依附的多功能材料的结合桥接层涂覆移植物，所述多层功能材料的化学结合与移植物的表面组分结合，然后是半透性的，生物相容的 层与化学键合到结合桥接层的聚合物层。

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