公开(公告)号：US20140107045A1

公开(公告)日：2014-04-17

申请号：US14136347

申请日：2013-12-20

Applicant: LABORATOIRE MEDIDOM SA

Inventor： Stefano Carlino ,  René-Pierre Bunter

IPC: A61K31/7032

CPC classification number: A61K31/7032 ,  C07H15/10

Abstract: A process for preparing pure monosialoganglioside GM1 in the form of its sodium salt. There is provided a process for the isolation and purification of monosialoganglioside GM1 comprising (a) separation of GM1 from a lipidic mixture containing the monosialoganglioside GM1 as the main ganglioside component by ion exchange column-chromatography using an eluent comprising potassium or caesium ions, (b) recovery of the solute from the eluted solution, (c) diafiltration of an aqueous solution of the recovered solute, and (d) second diafiltration after the addition of 1 M NaCl, and recovering GM1. The purity level of GM1 obtained is higher than 99.0%.

Abstract translation: 一种以其钠盐形式制备纯唾液酸神经节苷脂GM1的方法。 提供了一种用于分离和纯化单唾液酸神经节苷脂GM1的方法，其包括（a）通过使用包含钾或铯离子的洗脱液的离子交换柱色谱法分离GM1从含有单唾液酸神经节苷脂GM1作为主要神经节苷脂组分的脂质混合物（b ）从洗脱的溶液中回收溶质，（c）渗滤回收的溶质的水溶液，和（d）在加入1M NaCl后进行第二次渗滤，并回收GM1。 获得的GM1纯度高于99.0％。

公开(公告)号：US20170312364A1

公开(公告)日：2017-11-02

申请号：US15522789

申请日：2015-10-28

Applicant: LABORATOIRE MEDIDOM SA

Inventor： LEILA YOLANDA BOSSY ,  ALESSANDRO DI NAPOLI

IPC: A61K47/12 ,  A61K9/00 ,  A61K9/08 ,  A61K47/10 ,  C08L5/08 ,  A61K47/36 ,  A61L2/00 ,  A61K31/722

CPC classification number: A61K47/12 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/722 ,  A61K47/10 ,  A61K47/36 ,  A61L2/0023 ,  A61L2202/21 ,  C08L5/00 ,  C08L5/08 ,  C08L2201/54 ,  C08L2203/02 ,  C08L2205/02

Abstract: The present invention relates to a heat-sterilized aqueous composition comprising a solubilized chitosan and glycerol. It also relates to a process of preparation of the same, as well as the use thereof, including compositions useful for the prevention and treatment of dry eye syndrome and arthritic diseases or disorders.

公开(公告)号：US09498490B2

公开(公告)日：2016-11-22

申请号：US14136347

申请日：2013-12-20

Applicant: LABORATOIRE MEDIDOM SA

Inventor： Stefano Carlino ,  René-Pierre Bunter

IPC: A61K31/7032 ,  A61P25/00 ,  C07H1/06 ,  C07H15/10

CPC classification number: A61K31/7032 ,  C07H15/10

Abstract: A process for preparing pure monosialoganglioside GM1 in the form of its sodium salt. There is provided a process for the isolation and purification of monosialoganglioside GM1 comprising (a) separation of GM1 from a lipidic mixture containing the monosialoganglioside GM1 as the main ganglioside component by ion exchange column-chromatography using an eluent comprising potassium or caesium ions, (b) recovery of the solute from the eluted solution, (c) diafiltration of an aqueous solution of the recovered solute, and (d) second diafiltration after the addition of 1 M NaCl, and recovering GM1. The purity level of GM1 obtained is higher than 99.0%.

Abstract translation: 一种以其钠盐形式制备纯唾液酸神经节苷脂GM1的方法。 提供了一种用于分离和纯化单唾液酸神经节苷脂GM1的方法，其包括（a）通过使用包含钾或铯离子的洗脱液的离子交换柱色谱法分离GM1从含有单唾液酸神经节苷脂GM1作为主要神经节苷脂组分的脂质混合物（b ）从洗脱的溶液中回收溶质，（c）渗滤回收的溶质的水溶液，和（d）在加入1M NaCl后进行第二次渗滤，并回收GM1。 获得的GM1纯度高于99.0％。

公开(公告)号：US20160375046A1

公开(公告)日：2016-12-29

申请号：US15258673

申请日：2016-09-07

Applicant: LABORATOIRE MEDIDOM SA

Inventor： Stefano Carlino ,  René-Pierre Bunter

IPC: A61K31/7032

CPC classification number: A61K31/7032 ,  C07H15/10

Abstract: A process for preparing pure monosialoganglioside GM1 in the form of its sodium salt. There is provided a process for the isolation and purification of monosialoganglioside GM1 comprising (a) separation of GM1 from a lipidic mixture containing the monosialoganglioside GM1 as the main ganglioside component by ion exchange column-chromatography using an eluent comprising potassium or caesium ions, (b) recovery of the solute from the eluted solution, (c) diafiltration of an aqueous solution of the recovered solute, and (d) second diafiltration after the addition of 1 M NaCl, and recovering GM1. The purity level of GM1 obtained is higher than 99.0%.

Abstract translation: 一种以其钠盐形式制备纯唾液酸神经节苷脂GM1的方法。 提供了用于分离和纯化单唾液酸神经节苷脂GM1的方法，其包括（a）通过使用包含钾或铯离子的洗脱液的离子交换柱色谱法分离GM1从含有单唾液酸神经节苷脂GM1作为主要神经节苷脂组分的脂质混合物（b ）从洗脱的溶液中回收溶质，（c）渗滤回收的溶质的水溶液，和（d）在加入1M NaCl后进行第二次渗滤，并回收GM1。 获得的GM1纯度高于99.0％。

公开(公告)号：US20150011636A1

公开(公告)日：2015-01-08

申请号：US14268712

申请日：2014-05-02

Applicant: LABORATOIRE MEDIDOM SA

Inventor： Stefano CARLINO ,  Alessandro DI NAPOLI

IPC: C07C309/60

CPC classification number: C07C309/60 ,  C07C2603/24

Abstract: Compounds that may have anti-inflammatory activity have the general formula (I): Wherein R1, R2, R3 are each independently H or a C1-4 alkyl group or a C2-4 acyl group; R4 and R5 are each independently H or a group of formula —SO3R6, wherein R6 is H or a C1-4 alkyl group or a C2-4 acyl group; with the proviso that at least one of R4 and R5 is a group of formula —SO3R6, or a pharmaceutically acceptable salt thereof.

Abstract translation: 可具有抗炎活性的化合物具有通式（I）：其中R1，R2，R3各自独立为H或C1-4烷基或C2-4酰基; R4和R5各自独立地为H或式-SO3R6的基团，其中R6为H或C1-4烷基或C2-4酰基; 条件是R 4和R 5中的至少一个是式-SO 3 R 6的基团，或其药学上可接受的盐。