公开(公告)号：US20180182080A1

公开(公告)日：2018-06-28

申请号：US15905416

申请日：2018-02-26

Applicant: Ll-COR, Inc.

Inventor： Patrick Humphrey

IPC: G06T5/00 ,  G06T5/40 ,  G09G5/10

CPC classification number: G06T5/008 ,  G06T5/002 ,  G06T5/007 ,  G06T5/40 ,  G06T2207/20024 ,  G06T2207/20028 ,  G06T2207/20182 ,  G06T2207/20192 ,  G06T2207/20208 ,  G09G5/10 ,  G09G2320/0271 ,  G09G2320/029 ,  G09G2320/066 ,  G09G2320/0673 ,  G09G2320/08 ,  G09G2360/16

Abstract: Systems and method for processing image data of an image to determine a signal quantification value for a signal of interest in the image data. The method includes identifying a first region of the image including a plurality of pixels, each pixel having a pixel intensity value, said first region including the signal of interest and a background signal component; determining, using the image data, a total number of discrete pixel intensity values for the plurality of pixels in the first region; calculating, for each discrete pixel intensity value, a total number of the pixels in the first region having that discrete pixel intensity value; determining a mean value of the background signal component based on the total number of pixels for each discrete pixel intensity value; and calculating a signal quantification value, for the signal of interest, that represents the signal of interest with the background signal component removed.

公开(公告)号：US20150346202A1

公开(公告)日：2015-12-03

申请号：US14724063

申请日：2015-05-28

Applicant: Ll-COR, INC.

Inventor： Kousik Kundu ,  Ying Wang ,  Nisha Padhye

IPC: G01N33/573

CPC classification number: G01N33/573 ,  G01N33/533 ,  G01N33/582 ,  G01N2333/908

Abstract: The present invention relate to formulations, systems, kits and methods for chemiluminescence assays to detect the catalytic activity of a peroxidase. The present invention provides formulations and methods for chemiluminescence reactions that have significantly improved signal duration, which signal lasts for hours.

Abstract translation: 本发明涉及用于检测过氧化物酶的催化活性的化学发光测定的制剂，系统，试剂盒和方法。 本发明提供具有明显改善的信号持续时间的化学发光反应的制剂和方法，该信号持续数小时。

公开(公告)号：US20160144058A1

公开(公告)日：2016-05-26

申请号：US14949654

申请日：2015-11-23

Applicant: Ll-COR, INC.

Inventor： Daniel R. Draney ,  WILLIAM M. VOLCHECK ,  KATIE SCHAEPE ,  VASSIL ELITZIN ,  JOY KOVAR

IPC: A61K49/00 ,  A61B5/00 ,  A61B5/20 ,  C09B23/10

CPC classification number: A61K49/0032 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/20 ,  A61B5/4244 ,  C09B23/0025 ,  C09B23/0066 ,  C09B23/086 ,  C09B23/107

Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.

Abstract translation: 一种器官成像方法，其特征在于，包括：向患者施用诊断有效量的2 - （（E）-2 - （（E）-3-（2 - （（E）-3,3-二甲基-5-磺酸 -1-（4-磺酰基丁基）二氢吲哚-2-亚基）亚乙基）-2-苯氧基环己-1-烯-1-基）乙烯基）-3,3-二甲基-1-（4-磺酰基丁基） 1 - （ - ）（E）-2 - （（E）-3-（2 - （（E）-3,3-二甲基-5-磺酸基-1-（4-磺酰基丁基） 亚乙基）亚乙基）-2-（4-磺酰苯氧基）环己-1-烯-1-基）乙烯基）-3,3-二甲基-1-（4-磺酰基丁基）-3H-吲哚-1-基 - 5-磺酸盐。 在一个实施方案中，器官包括肾，膀胱，肝，胆囊，脾，肠，心脏，肺和肌肉中的一种或多种。

公开(公告)号：US20160091420A1

公开(公告)日：2016-03-31

申请号：US14870425

申请日：2015-09-30

Applicant: Ll-COR, Inc.

Inventor： Serguei KOULIKOV

IPC: G01N21/39 ,  G02B5/20 ,  G02B5/30 ,  H01S5/00 ,  H01S3/081

CPC classification number: G01N21/39 ,  G01N2021/1704 ,  G01N2021/399 ,  G01N2201/0642 ,  G02B5/205 ,  G02B5/3066 ,  H01S3/081 ,  H01S5/0014 ,  H01S5/0078

Abstract: Laser-based spectroscopy systems and methods including a laser source that emits a beam of radiation, an optical resonant cavity having at least two cavity mirrors, and at least one beam filtering element positioned along a path of the beam external to the cavity and having a front surface, wherein the front surface is oriented such that an intersection of the beam and the surface is at an angle, such as the Brewster's angle or a pseudo-Brewster's, that reduces or eliminates reflection of a predominant polarization component of the beam by the filtering element.

Abstract translation: 基于激光的光谱系统和方法，包括发射辐射束的激光源，具有至少两个空腔反射镜的光学谐振腔，以及沿着腔外部的光束路径定位的至少一个光束过滤元件， 前表面，其中所述前表面被定向成使得所述光束和所述表面的交叉点成一定角度，例如布鲁斯特角或伪布鲁斯特，以减少或消除所述光束的主要偏振分量的反射。 过滤元件。

公开(公告)号：US20150343060A1

公开(公告)日：2015-12-03

申请号：US14728204

申请日：2015-06-02

Applicant: Ll-COR, INC.

Inventor： JOY L. KOVAR ,  HAN-WEI WANG

IPC: A61K41/00 ,  A61M1/36

CPC classification number: A61K41/0071 ,  A61K41/0009 ,  A61K47/64 ,  A61K47/6415 ,  A61K47/642 ,  A61K47/6849 ,  A61K49/0032 ,  A61K49/005 ,  A61K51/0446 ,  A61K51/0497 ,  A61K51/082 ,  A61K51/083 ,  A61K51/088 ,  A61M1/3618 ,  A61M1/3683 ,  A61M1/3686 ,  A61N5/062 ,  A61N2005/0658

Abstract: The present invention relates to methods and compositions for eliminating circulating tumor cells (CTCs) in a patient with or without solid tumors. In particular, the ex vivo method utilizes a photodynamic or magnetic targeting moiety that specifically binds to antigens expressed on the cell surface of CTCs.

Abstract translation: 本发明涉及用于消除或不用实体瘤的患者中循环肿瘤细胞（CTC）的方法和组合物。 特别地，离体方法利用特异性结合CTC细胞表面上表达的抗原的光动力或磁性靶向部分。