公开(公告)号：US07867194B2

公开(公告)日：2011-01-11

申请号：US11503450

申请日：2006-08-11

Applicant: Jason Fiering ,  Mark Mescher

Inventor： Jason Fiering ,  Mark Mescher

IPC: A61M29/00 ,  A61M37/00 ,  A61M31/00 ,  A61N1/30

CPC classification number: A61F11/002 ,  A61M5/14216 ,  A61M5/14224 ,  A61M5/14276 ,  A61M31/002 ,  A61M2205/0244 ,  A61M2210/0662 ,  A61M2210/0668

Abstract: An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a body cavity of a patient over a period of time includes a variable-volume vessel defining a working chamber for receiving a drug and recirculating a therapeutic fluid. The fluid can contain a bodily fluid, such as, for example, perilymph, and a drug. The device allows for the controlled delivery of the therapeutic fluid to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear.

Abstract translation: 一种用于在一段时间内将药物输送到患者体腔中的体液中的可植入药物递送装置包括限定用于接收药物并再循环治疗流体的工作室的可变容积容器。 流体可以包含体液，例如外淋巴液和药物。 该装置允许将治疗流体受控地输送到患者体腔中的预定位置，例如人耳的耳蜗。

公开(公告)号：US20080009836A1

公开(公告)日：2008-01-10

申请号：US11503450

申请日：2006-08-11

Applicant: Jason Fiering ,  Mark Mescher

Inventor： Jason Fiering ,  Mark Mescher

IPC: A61K9/22

CPC classification number: A61F11/002 ,  A61M5/14216 ,  A61M5/14224 ,  A61M5/14276 ,  A61M31/002 ,  A61M2205/0244 ,  A61M2210/0662 ,  A61M2210/0668

Abstract: An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a body cavity of a patient over a period of time includes a variable-volume vessel defining a working chamber for receiving a drug and recirculating a therapeutic fluid. The fluid can contain a bodily fluid, such as, for example, perilymph, and a drug. The device allows for the controlled delivery of the therapeutic fluid to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear.

Abstract translation: 一种用于在一段时间内将药物输送到患者体腔中的体液中的可植入药物递送装置包括限定用于接收药物并再循环治疗流体的工作室的可变容积容器。 流体可以包含体液，例如外淋巴液和药物。 该装置允许将治疗流体受控地输送到患者体腔中的预定位置，例如人耳的耳蜗。

公开(公告)号：US20060167435A1

公开(公告)日：2006-07-27

申请号：US10545726

申请日：2004-02-17

Applicant: Anthony Adamis ,  Joan Miller ,  Mark Mescher ,  Evangelos Gragoudas ,  Jeffrey Borenstein

Inventor： Anthony Adamis ,  Joan Miller ,  Mark Mescher ,  Evangelos Gragoudas ,  Jeffrey Borenstein

IPC: A61M31/00

CPC classification number: A61F9/0017

Abstract: The invention provides a low-profile, dome-shaped body for attachment to a scleral surface of an eye and defining an internal cavity for receiving a drug or other pharmaceutically active agent. The device has an opening for controllably delivering the drug into the eye at therapeutically effective concentrations over a prolonged period of time. When attached, the device does not affect or otherwise restrict movement of the eye. Features of the invention include an optional drug inlet port and puncture guard, both designed for refilling the device while preventing a needle inserted through the inlet port from contacting the sclera.

Abstract translation: 本发明提供了一种用于附着到眼睛的巩膜表面并限定用于接收药物或其它药物活性剂的内腔的低角度圆顶形体。 该装置具有用于在长时间内以治疗有效浓度可控地将药物输送到眼睛中的开口。 安装时，设备不会影响或限制眼睛的运动。 本发明的特征包括可选的药物入口和穿刺保护装置，两者设计用于在防止穿过入口插入的针头接触巩膜的同时重新填充装置。

公开(公告)号：US20060030837A1

公开(公告)日：2006-02-09

申请号：US11046540

申请日：2005-01-28

Applicant: Michael McKenna ,  Jason Fiering ,  Mark Mescher ,  Sharon Kujawa ,  William Sewell ,  Anthony Mikulec

Inventor： Michael McKenna ,  Jason Fiering ,  Mark Mescher ,  Sharon Kujawa ,  William Sewell ,  Anthony Mikulec

IPC: A61K9/22

CPC classification number: A61M5/14276 ,  A61F11/00 ,  A61M5/14224 ,  A61M5/1723 ,  A61M31/002 ,  A61M2205/0244 ,  A61M2205/3379 ,  A61M2210/0662 ,  A61M2210/0668

Abstract: An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a body cavity of a patient over a period of time, which includes a hollow member that defines at least one lumen for facilitating a unidirectional recirculating flow of a therapeutic fluid through the lumen. The fluid can contain a bodily fluid, such as, for example, perilymph, and a drug. The apparatus also includes a pump, for example a single unidirectional pump, to control the flow rate of the therapeutic fluid through the hollow member, and an interface member in communication with at least one lumen of the hollow member. The device thus allows for the controlled delivery of the therapeutic fluid to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear.

Abstract translation: 一种可植入药物输送装置，用于将药物输送到患者体腔中的体液一段时间，该时间段包括限定至少一个内腔的中空构件，以便于治疗流体通过内腔的单向循环流动 。 流体可以包含体液，例如外淋巴液和药物。 该装置还包括泵，例如单个单向泵，以控制通过中空构件的治疗流体的流速，以及与中空构件的至少一个内腔连通的界面构件。 因此，该装置允许治疗性流体的受控输送到患者体腔中的预定位置，例如人耳的耳蜗。

公开(公告)号：US20050238506A1

公开(公告)日：2005-10-27

申请号：US11169211

申请日：2005-06-28

Applicant: Mark Mescher ,  Jason Fiering ,  Christopher Dube

Inventor： Mark Mescher ,  Jason Fiering ,  Christopher Dube

IPC: F04B17/00 ,  F04B35/04 ,  F04B43/04

CPC classification number: F04B43/043 ,  A61M5/14224 ,  A61M5/14276 ,  A61M2205/0244 ,  A61M2210/0662 ,  A61M2210/0668 ,  F04B35/045 ,  F04B43/046 ,  G05D7/0694

Abstract: A variable, closed-loop apparatus for regulating a microfluidic flow that employs a low-power deflection assembly, which is surface-mounted over a flexible membrane overlying a chamber integrated into a microfabricated platform. A flexible membrane, moveable between two positions, sealingly overlies the chamber. One of the positions of the membrane restricts the flow through the chamber to a greater degree than the other position. A deflection assembly disposed on the substrate over the membrane unidirectionally deflects the membrane, thereby regulating the flow through the chamber.

Abstract translation: 一种用于调节微流体流动的可变的闭环装置，其采用低功率偏转组件，该低功率偏转组件被表面安装在覆盖在集成到微加工平台中的室的柔性膜上。 柔性膜可在两个位置之间移动，密封地覆盖室。 膜的位置之一限制了通过腔室的流动比其他位置更大的程度。 设置在膜上的基板上的偏转组件单向偏转膜，从而调节通过室的流动。

公开(公告)号：US20060051883A1

公开(公告)日：2006-03-09

申请号：US11181035

申请日：2005-07-13

Applicant: Mark Mescher ,  Mathew Varghese ,  Marc Weinberg ,  Thomas Marinis ,  Joseph Soucy

Inventor： Mark Mescher ,  Mathew Varghese ,  Marc Weinberg ,  Thomas Marinis ,  Joseph Soucy

IPC: H01L21/00

CPC classification number: B81B7/0012 ,  G04F5/14 ,  H01L2924/0002 ,  H01L2924/00

Abstract: A suspension of a chip-scale device is accomplished using a suspension frame and at least one first tether. The chip-scale suspension frame defines a first plane and an opening through the suspension frame. At least one first tether crosses the opening at a first angle relative to the first plane and can be used to position the chip-scale device at least partially within the opening.

Abstract translation: 使用悬挂框架和至少一个第一系绳来实现芯片级装置的悬架。 芯片级悬挂框架限定了第一平面和通过悬挂框架的开口。 至少一个第一系绳相对于第一平面以第一角度穿过开口，并且可以用于将芯片尺寸装置至少部分地定位在开口内。

公开(公告)号：US20070240294A1

公开(公告)日：2007-10-18

申请号：US11253451

申请日：2005-10-19

Applicant: Amy Duwel ,  David Carter ,  Mark Mescher ,  Mathew Varghese ,  Bernard Antkowiak ,  Marc Weinberg

Inventor： Amy Duwel ,  David Carter ,  Mark Mescher ,  Mathew Varghese ,  Bernard Antkowiak ,  Marc Weinberg

IPC: H04R17/00

CPC classification number: H03H3/02 ,  H03H9/172 ,  H03H9/564 ,  H03H9/586 ,  H03H2003/027 ,  H03H2009/241 ,  H04R17/00 ,  Y10T29/42 ,  Y10T29/435

Abstract: A longitudinal mode resonator that includes a substrate and a bar that is suspended relative to the substrate. The bar is suspended such that it is free to expand and contract longitudinally in response to the application of an electric field across its thickness. The expansion and contraction of the bar achieves resonance in response to the field having a frequency substantially equal to the fundamental frequency of the bar.

Abstract translation: 一种纵模式谐振器，其包括相对于衬底悬挂的衬底和棒。 该杆被悬挂使得响应于其整个厚度上的电场的应用而使它自由地纵向膨胀和收缩。 棒的膨胀和收缩响应于具有与棒的基本频率基本相等的频率的场来实现谐振。