公开(公告)号：US20060215824A1

公开(公告)日：2006-09-28

申请号：US11107696

申请日：2005-04-15

Applicant: David Mitby ,  Andrea Klein ,  Matthew O'Connor ,  Matthew Marx ,  Craig Nicol ,  Jonathan Katzman ,  Firooz Partovi

Inventor： David Mitby ,  Andrea Klein ,  Matthew O'Connor ,  Matthew Marx ,  Craig Nicol ,  Jonathan Katzman ,  Firooz Partovi

IPC: H04M11/00

CPC classification number: H04M3/493 ,  G10L15/22

Abstract: Described is a method of handling automated conversations by categorizing a plurality of events which occur during automated conversations based on an impact of the events on a level of user satisfaction with the automated conversations, assigning to each category of events a quality score corresponding to the impact on user satisfaction of the events in each category and initiating a conversation handling action for one of the conversations based on the categories of events detected during the one of the conversations.

Abstract translation: 描述了一种处理自动会话的方法，该方法通过对基于事件对自动对话的用户满意度的影响的自动对话期间发生的多个事件进行分类，向每个类别的事件分配对应于影响的质量得分 用户对每个类别中的事件的满意度，并且基于在一个对话期间检测到的事件的类别来启动对话之一的对话处理动作。

公开(公告)号：US07285077B1

公开(公告)日：2007-10-23

申请号：US10732779

申请日：2003-12-09

Applicant: Matthew Marx

Inventor： Matthew Marx

IPC: A63B21/078 ,  A63B26/00

CPC classification number: A63B21/078 ,  A63B21/00047 ,  A63B21/06 ,  A63B21/0726 ,  A63B21/0783 ,  A63B21/4029 ,  A63B2208/0252

Abstract: The present invention 10 discloses a workout bench 26 having a plurality of incline adjustments and stanchions with means for receiving dumbbell weights 12. The dumbbell stanchion comprises a tubular structure 16 having a base portion 38 extending transversely to its distal ends, forming vertical stanchions. The vertical stanchions 16 comprise a weight rest stanchion 18 with weight rest 19 that is slidably adjustable having apertures 22 linearly arranged in conjunction with a locking pin 24 provided on the main vertical stanchions. The bench comprises two cushions 28 fixedly attached to individual frame structures 30 each hingedly 32 connected at the center. At the other distal end of the cushion frame 30 are collapsible leg supports 34 that fold up allowing the cushions 28 to rest on the floor's surface at an angle from the pivot point. Also disclosed are internal extendable braces 42 for raising the cushions 28.

Abstract translation: 本发明10公开了一种具有多个倾斜调节和支撑杆的锻炼工作台26，其具有用于接收哑铃重物12的装置。 哑铃支柱包括具有横向于其远端延伸的基部38的管状结构16，形成竖直的支柱。 垂直支柱16包括具有重量托架19的重量支架18，其具有可滑动调节，具有与设置在主垂直支柱上的锁定销24线性地布置的孔22。 工作台包括固定地连接到单个框架结构30的两个衬垫28，每个框架结构30在中心连接有铰接32。 在靠垫框架30的另一个远端是可折叠的腿部支撑件34，其可折叠，允许衬垫28以与摆动点成一定角度放置在地板表面上。 还公开了用于升高衬垫28的内部可延伸的支架42。

公开(公告)号：US20060035912A1

公开(公告)日：2006-02-16

申请号：US11140411

申请日：2005-05-27

Applicant: Matthew Marx ,  Jinshan Chen ,  Susan Lagreca

Inventor： Matthew Marx ,  Jinshan Chen ,  Susan Lagreca

IPC: A61K31/519 ,  C07D487/02

CPC classification number: C07D487/04

Abstract: The invention relates to compounds of the formula 1 or a pharmaceutically acceptable salt, prodrug, solvate or hydrate thereof, wherein L, R1, R2 R3 and R4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating abnormal cell growth, such as cancer in a mammal by administering the compounds of formula 1.

Abstract translation: 本发明涉及式1化合物或其药学上可接受的盐，前药，溶剂合物或水合物，其中L，R 1，R 2，R 3， / SUP>和R 4'如本文所定义。 本发明还涉及含有式1化合物的药物组合物和通过施用式1化合物治疗哺乳动物异常细胞生长如癌症的方法。

公开(公告)号：US20050256177A1

公开(公告)日：2005-11-17

申请号：US11131020

申请日：2005-05-16

Applicant: Matthew Marx ,  Chandra Prakash ,  Zhuang Miao

Inventor： Matthew Marx ,  Chandra Prakash ,  Zhuang Miao

IPC: A61K31/425 ,  C07D275/02 ,  C07D275/03 ,  C07D417/02

CPC classification number: C07D275/03

Abstract: The invention relates to compounds of the formula 1 wherein X1, X2 and X3 independently is a halogen; p is an integer from 1 to 3; and R is —COOH, OR1 wherein R1 is a substituted isothiazole ring, or SR2 wherein R2 is (CH2)qC(COOH)(NHC(O)R3) wherein q is an integer from 0 to 3, and R3 is (C1-C4)alkyl; and to pharmaceutically acceptable salts, prodrugs and solvates thereof. The invention also relates to methods of treating a hyperproliferative disorder in a mammal by administering the compounds of formula 1 and to pharmaceutical compositions containing the compounds of formula 1.

Abstract translation: 本发明涉及式1的化合物，其中X 1，X 2和X 3独立地是卤素; p是1至3的整数; 并且R是-COOH，其中R 1是取代的异噻唑环或其中R 2 O 2的SR 2 是（CH 2）2 C（COOH）（NHC（O）R 3）其中q是0-3的整数， 和R 3是（C 1 -C 4 - ）烷基; 以及其药学上可接受的盐，前药和溶剂化物。 本发明还涉及通过施用式1化合物和含有式1化合物的药物组合物来治疗哺乳动物中过度增殖性疾病的方法。

公开(公告)号：US20050130994A1

公开(公告)日：2005-06-16

申请号：US10989842

申请日：2004-11-16

Applicant: Jinshan Chen ,  Matthew Marx ,  Susan LaGreca ,  Matthew Wessel

Inventor： Jinshan Chen ,  Matthew Marx ,  Susan LaGreca ,  Matthew Wessel

IPC: A61K31/519 ,  C07D487/02 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: The invention relates to compounds of the formula 1 or a pharmaceutically acceptable salt, prodrug or hydrates thereof, wherein X, L, R1, R2, R3 and R4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula 1.

Abstract translation: 本发明涉及式1化合物或其药学上可接受的盐，前药或水合物，其中X，L，R 1，R 2，R 3， ＆lt; / SUP＆gt;和R 4＆gt;如本文所定义。 本发明还涉及含有式1化合物的药物组合物和通过施用式1化合物治疗哺乳动物中过度增殖性疾病的方法。

公开(公告)号：US20050037999A1

公开(公告)日：2005-02-17

申请号：US10732509

申请日：2003-12-10

Applicant: Susan La Greca ,  Joel Arcari ,  Jinshan Chen ,  Matthew Marx ,  Matthew Wessel

Inventor： Susan La Greca ,  Joel Arcari ,  Jinshan Chen ,  Matthew Marx ,  Matthew Wessel

IPC: A61K31/505 ,  A61P35/00 ,  C07D487/04 ,  A61K31/675 ,  A61K31/519 ,  C07D487/02

CPC classification number: C07D487/04

Abstract: The invention relates to compounds of the formula 1 or a pharmaceutically acceptable salt, prodrug or hydrates thereof, wherein Q, A, L, R1, R2 and R3 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula 1.

Abstract translation: 本发明涉及式1化合物或其药学上可接受的盐，前药或水合物，其中Q，A，L，R 1，R 2和R 3如本文所定义。 本发明还涉及含有式1化合物的药物组合物和通过施用式1化合物治疗哺乳动物中过度增殖性疾病的方法。