METHOD FOR TREATIG CANCER BY DISABILING BRACA1/FANCM INTERACTION

    公开(公告)号:US20210180056A1

    公开(公告)日:2021-06-17

    申请号:US16074313

    申请日:2017-02-15

    Inventor: Dong ZHANG

    Abstract: The method involves an approach of inhibiting replication of dysfunctional cells which adopt alternative lengthening of telomeres, or “ALT.” The methodology involves inhibition of Fanconi anemia complementation group M (FANCM), and one or both of breast cancer 1 (BRCA1) and Bloom syndrome protein (BLM). These molecules are the keys to the elimination of replication stress caused by ALT. In other words, they permit the dysfunctional cells to proliferate. Inhibition of these molecules inhibits proliferation.

    DIRECT NUCLEIC ACID SEQUENCING METHOD

    公开(公告)号:US20210198734A1

    公开(公告)日:2021-07-01

    申请号:US17058167

    申请日:2019-05-24

    Abstract: The present disclosure relates generally to novel methods for nucleic acid sequencing. Specifically, the invention relates to a liquid chromatography-mass-spectrometry (LC-MS) based technique for direct sequencing of RNA without cDNA. The technique allows one to simultaneously read an RNA sequence with single nucleotide resolution while determining the presence, type and location of a wide spectrum of RNA modifications.

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