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公开(公告)号：US12195454B2
公开(公告)日：2025-01-14
申请号：US18144547
申请日：2023-05-08
Inventor： Makoto Higuchi , Tetsuya Suhara , Masahiro Maruyama , Meiei Cho , Hitoshi Shimada
IPC: C07D417/06 , A61K49/00 , C07D277/64 , C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D417/14 , C07F7/18
Abstract: The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein: R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; ring A is a benzene ring or a pyridine ring; ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): in the formula (ii), Ra is alkyl; R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.
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公开(公告)号：US20220133698A1
公开(公告)日：2022-05-05
申请号：US17432776
申请日：2020-01-24
Inventor： Makoto Higuchi , Maiko Ono , Tetsuya Suhara , Meiei Cho
IPC: A61K31/426 , A61K31/443 , A61K31/4436 , A61P25/16 , A61P25/28 , A61K51/04
Abstract: The present invention provides an α-synuclein aggregate binding agent that has high binding selectivity for an α-synuclein aggregate.
The α-synuclein aggregate binding agent contains a compound represented by a formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: in the formula (I), R1 and R2 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; the ring A is a benzene or pyridine ring; the ring B is represented by the following formula (i) or (ii): R4 and R5 are each independently selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl.-
公开(公告)号：US20210247366A1
公开(公告)日：2021-08-12
申请号：US16981717
申请日：2019-03-27
Inventor： Masaharu Nishikino , Noboru Hasegawa , Katsuhiro Mikami , Toshiyuki Kitamura , Shuji Kondo , Hajime Okada , Tetsuya Kawachi , Yoshinori Shimada , Shinri Kurahashi
Abstract: A measuring device for measuring an inspection target on the basis of vibration generated when the inspection target has been irradiated with laser light includes a condensing position deriving portion configured to derive an amount of adjustment of a distance between condensing lenses of a laser condensing unit configured to condense the laser light on the basis of a distance between a laser device configured to radiate the laser light and an irradiation location of the laser light and a communicating portion configured to transmit control information including information representing the amount of adjustment to the laser condensing unit.
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公开(公告)号：US10806385B2
公开(公告)日：2020-10-20
申请号：US15545661
申请日：2016-01-19
Inventor： Koichi Yamakawa
IPC: A61B5/1455 , G01N21/55 , A61B5/145 , G02F1/35 , G02F1/39 , A61B90/30 , A61B90/00 , H01S3/16 , H01S3/223
Abstract: The concentration of substance in blood is measured non-invasively, with high accuracy and with simple configuration. Laser light generated by a light source is locally irradiated on the body epithelium of a subject, and the resulting diffused reflected light is detected by a light detector. The laser light has a wavelength of 9.26 μm. The laser light is generated by converting and amplifying pulsed excitation light from an excitation light source to a long wavelength. A plate-shaped window that is transparent to mid-infrared light is brought in close contact with the body epithelium. The glucose concentration in interstitial fluid can be calculated using normalized light intensity calculated from a signal ratio of signals from a monitoring light detector and light detector.
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公开(公告)号：US20200231924A1
公开(公告)日：2020-07-23
申请号：US16620400
申请日：2018-05-17
Applicant: IWASAKI ELECTRIC CO., LTD. , NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGY
Inventor： Shinobu KINOSHITA , Takashi IDE , Tomoko OYAMA , Mitsumasa TAGUCHI , Bin Jeremiah Duenas BARBA
IPC: C12M1/42 , B01L3/00 , C08F283/12 , B01J19/12 , C12M1/32
Abstract: Provided are a substrate for test use that is preferable for use in a test such as a culture test, and a method for manufacturing the substrate for test use. The substrate for test use, in which a solution retaining part for retaining water or an aqueous solution, is formed at a surface of a substrate of polydimethylsiloxane (PDMS). The solution retaining part is a concave part having a hydrophilic surface layer. The surface layer has a maximum thickness of 1 μm or larger.
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Patent Agency Ranking
公开(公告)号：US10604516B2
公开(公告)日：2020-03-31
申请号：US14346914
申请日：2012-12-21
Inventor： Makoto Higuchi , Tetsuya Suhara , Masahiro Maruyama , Meiei Cho , Hitoshi Shimada
IPC: A61B8/00 , A61B5/00 , A61B10/00 , C07D417/06 , C07F7/18 , C07D401/06 , C07D405/06 , C07D417/14 , C07D277/64 , A61K49/00 , C07D401/14 , C07D405/14
Abstract: The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof. wherein: R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; ring A is a benzene ring or a pyridine ring; ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): in the formula (ii), Ra is alkyl; R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and [Formula 3] represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.
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公开(公告)号：US10444383B2
公开(公告)日：2019-10-15
申请号：US15895501
申请日：2018-02-13
Inventor： Taiga Yamaya , Hideaki Tashima
Abstract: A partial-ring PET device, in which some of coincidence radiation detectors to be arranged in a ring shape around a field of view for detecting lines of response of annihilation radiations are missing, is compensated for a drop in image quality due to the missing of the coincidence radiation detectors by including single gamma-ray radiation detectors for detecting at least either one of the annihilation radiations as a single gamma-ray. This can reduce missing of projection angles and reduce artifacts in PET images.
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公开(公告)号：US20190302206A1
公开(公告)日：2019-10-03
申请号：US16368545
申请日：2019-03-28
Inventor： Md Shahadat Hossain Akram , Takayuki OBATA , Taiga YAMAYA
IPC: G01R33/422 , G01R33/48 , G01R33/34 , G01R33/36 , H01P3/08
Abstract: PET or SPECT insert for MRI or MRS system with medium (3 T for example) to ultra high (7 T for example) magnetic field is provided. RF shielded radiation detector modules are separately disposed in a form of full or partial ring shape. The RF shielded radiation detector modules are electric ground conductors for microstrip transmission line coil RF array. Decoupling circuits in between grounded shield and/or in between microstrip conductors make electric isolation between coil elements.
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公开(公告)号：US20180239037A1
公开(公告)日：2018-08-23
申请号：US15895501
申请日：2018-02-13
Inventor： Taiga YAMAYA , Hideaki TASHIMA
CPC classification number: G01T1/2985 , G01R33/481 , G01T1/1647
Abstract: A partial-ring PET device, in which some of coincidence radiation detectors to be arranged in a ring shape around a field of view for detecting lines of response of annihilation radiations are missing, is compensated for a drop in image quality due to the missing of the coincidence radiation detectors by including single gamma-ray radiation detectors for detecting at least either one of the annihilation radiations as a single gamma-ray. This can reduce missing of projection angles and reduce artifacts in PET images.
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公开(公告)号：US11674933B2
公开(公告)日：2023-06-13
申请号：US16981717
申请日：2019-03-27
Inventor： Masaharu Nishikino , Noboru Hasegawa , Katsuhiro Mikami , Toshiyuki Kitamura , Shuji Kondo , Hajime Okada , Tetsuya Kawachi , Yoshinori Shimada , Shinri Kurahashi
CPC classification number: G01N29/348 , G01N29/2418
Abstract: A measuring device for measuring an inspection target on the basis of vibration generated when the inspection target has been irradiated with laser light includes a condensing position deriving portion configured to derive an amount of adjustment of a distance between condensing lenses of a laser condensing unit configured to condense the laser light on the basis of a distance between a laser device configured to radiate the laser light and an irradiation location of the laser light and a communicating portion configured to transmit control information including information representing the amount of adjustment to the laser condensing unit.
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