公开(公告)号：US20120095233A1

公开(公告)日：2012-04-19

申请号：US12103882

申请日：2008-04-16

Applicant: Jason W. Brown ,  Qing Dong ,  Bheema R. Paraselli ,  Jeffrey A. Stafford ,  Michael B. Wallace ,  Hasanthi Wijesekera ,  Nicholas Scorah

Inventor： Jason W. Brown ,  Qing Dong ,  Bheema R. Paraselli ,  Jeffrey A. Stafford ,  Michael B. Wallace ,  Hasanthi Wijesekera ,  Nicholas Scorah

IPC: C07D471/04 ,  C07D209/88

CPC classification number: C07D471/14 ,  C07D241/18 ,  C07D401/12 ,  C07D471/04 ,  C07D487/04

Abstract: Compounds are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Abstract translation: 提供化合物用于与包含选自以下的化合物的激酶一起使用：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

公开(公告)号：US08119655B2

公开(公告)日：2012-02-21

申请号：US11539857

申请日：2006-10-09

Applicant: Qing Dong ,  Bheema R. Paraselli ,  Nicholas Scorah ,  Jeffrey A. Stafford ,  Michael B. Wallace

Inventor： Qing Dong ,  Bheema R. Paraselli ,  Nicholas Scorah ,  Jeffrey A. Stafford ,  Michael B. Wallace

IPC: A61K31/437 ,  C07D471/04

CPC classification number: C07D471/04 ,  C07D471/12 ,  C07D487/04 ,  C07D487/14

Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.

公开(公告)号：US08791107B2

公开(公告)日：2014-07-29

申请号：US13404958

申请日：2012-02-24

Applicant: Edcon Chang ,  Tony Gibson ,  Bohan Jin ,  Nicholas Scorah ,  Qing Dong

Inventor： Edcon Chang ,  Tony Gibson ,  Bohan Jin ,  Nicholas Scorah ,  Qing Dong

IPC: A61K31/5383 ,  C07D498/14

CPC classification number: C07D498/14 ,  A61K31/5383 ,  A61K45/06

Abstract: Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein Ar, R1, R2, R3, G1, G2, and m are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating inflammatory disorders, cardiovascular disease, cancer, and other conditions associated with PI3Kδ.

Abstract translation: 公开了式1的化合物及其药学上可接受的盐，其中Ar，R1，R2，R3，G1，G2和m在说明书中定义。 本公开还涉及用于制备式1化合物的材料和方法，含有它们的药物组合物及其用于治疗与PI3Kδ相关的炎性疾病，心血管疾病，癌症和其它病症的用途。

公开(公告)号：US08288536B2

公开(公告)日：2012-10-16

申请号：US12755301

申请日：2010-04-06

Applicant: Qing Dong ,  David J. Hosfield ,  Bheema R. Paraselli ,  Nicholas Scorah ,  Jeffrey A. Stafford ,  Michael B. Wallace ,  Zhiyuan Zhang

Inventor： Qing Dong ,  David J. Hosfield ,  Bheema R. Paraselli ,  Nicholas Scorah ,  Jeffrey A. Stafford ,  Michael B. Wallace ,  Zhiyuan Zhang

IPC: C07D487/04 ,  A61K31/517 ,  A61P19/02

CPC classification number: C07D487/04

Abstract: Compounds, pharmaceutical compositions and kits are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.

Abstract translation: 化合物，药物组合物和试剂盒提供用于包含选自以下的化合物的激酶：其中变量如本文所定义。

公开(公告)号：US20100160633A1

公开(公告)日：2010-06-24

申请号：US12706837

申请日：2010-02-17

Applicant: Jason W. Brown ,  Qing Dong ,  Bheema R. Paraselli ,  Jeffrey A. Stafford ,  Xianchang Gong ,  Yan Liu ,  Nicholas Scorah ,  Michael B. Wallace

Inventor： Jason W. Brown ,  Qing Dong ,  Bheema R. Paraselli ,  Jeffrey A. Stafford ,  Xianchang Gong ,  Yan Liu ,  Nicholas Scorah ,  Michael B. Wallace

IPC: C07F9/06

CPC classification number: C07F9/6561 ,  C07D471/04

Abstract: Compounds are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Abstract translation: 提供化合物用于与包含选自以下的化合物的激酶一起使用：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

公开(公告)号：US20090124595A1

公开(公告)日：2009-05-14

申请号：US12267353

申请日：2008-11-07

Applicant: MarK Adams ,  Qing Dong ,  Toufike Kanouni ,  Stephen W. Kaldor ,  Nicholas Scorah ,  Michael B. Wallace

Inventor： MarK Adams ,  Qing Dong ,  Toufike Kanouni ,  Stephen W. Kaldor ,  Nicholas Scorah ,  Michael B. Wallace

IPC: C07D471/04 ,  A61K31/437 ,  A61K31/4375 ,  C07D513/04 ,  C07D498/04 ,  A61P35/04 ,  C12N9/99

CPC classification number: C07D471/04 ,  C07D498/04 ,  C07D513/04

Abstract: Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Abstract translation: 提供下式的化合物用于MEK：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

公开(公告)号：US20070117816A1

公开(公告)日：2007-05-24

申请号：US11539857

申请日：2006-10-09

Applicant: Jason Brown ,  Sanjib Das ,  Qing Dong ,  Xianchang Gong ,  Stephen Kaldor ,  Yan Liu ,  Bheema Paraselli ,  Nicholas Scorah ,  Jeffrey Stafford ,  Michael Wallace

Inventor： Jason Brown ,  Sanjib Das ,  Qing Dong ,  Xianchang Gong ,  Stephen Kaldor ,  Yan Liu ,  Bheema Paraselli ,  Nicholas Scorah ,  Jeffrey Stafford ,  Michael Wallace

IPC: A61K31/519 ,  A61K31/4745 ,  C07D471/02 ,  C07D487/02

CPC classification number: C07D471/04 ,  C07D471/12 ,  C07D487/04 ,  C07D487/14

Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.

Abstract translation: 提供化合物，药物组合物，试剂盒和方法用于包含选自以下的化合物的激酶：其中变量如本文所定义。

公开(公告)号：US08293901B2

公开(公告)日：2012-10-23

申请号：US12520247

申请日：2007-12-18

Applicant: Qing Dong ,  Nicholas Scorah ,  Steven W Kaldor

Inventor： Qing Dong ,  Nicholas Scorah ,  Steven W Kaldor

IPC: C07D471/04 ,  A61K31/519 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: Compounds of the following formula are provided for use with MEK (I): wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Abstract translation: 提供下式的化合物用于MEK（I）：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

公开(公告)号：US08278450B2

公开(公告)日：2012-10-02

申请号：US12103882

申请日：2008-04-16

Applicant: Jason W. Brown ,  Qing Dong ,  Bheema R. Paraselli ,  Nicholas Scorah ,  Jeffrey A. Stafford ,  Michael B. Wallace ,  Hasanthi Wijesekera

Inventor： Jason W. Brown ,  Qing Dong ,  Bheema R. Paraselli ,  Nicholas Scorah ,  Jeffrey A. Stafford ,  Michael B. Wallace ,  Hasanthi Wijesekera

IPC: C07D471/00 ,  C07D209/88

CPC classification number: C07D471/14 ,  C07D241/18 ,  C07D401/12 ,  C07D471/04 ,  C07D487/04

Abstract: Compounds are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Abstract translation: 提供化合物用于与包含选自以下的化合物的激酶一起使用：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

公开(公告)号：US20120178924A1

公开(公告)日：2012-07-12

申请号：US13429865

申请日：2012-03-26

Applicant: Bohan Jin ,  Nicholas Scorah ,  Qing Dong

Inventor： Bohan Jin ,  Nicholas Scorah ,  Qing Dong

IPC: C07D498/14

CPC classification number: C07D498/14

Abstract: The present invention relates to intermediates of the formula wherein G1 is N; G2 is selected from the group consisting of C═O and CH2; X is a halogen; and the other groups are defined herein.

Abstract translation: 本发明涉及下式的中间体，其中G1是N; G2选自C = O和CH 2; X是卤素; 并且其他组在本文中定义。