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公开(公告)号:US12251471B2
公开(公告)日:2025-03-18
申请号:US17872830
申请日:2022-07-25
Applicant: Oregon State University
Inventor: Jeonghwan Kim , Gaurav Sahay
IPC: A61K9/1272 , A61K9/00 , A61K31/7105
Abstract: Disclosed herein are embodiments of a nanoparticle composition suitable for delivering a therapeutic agent to a subject by nebulization. The nanoparticle comprises an ionizable lipid, cholesterol or a derivative thereof, a structural lipid, and a PEG lipid. The nanoparticle may partially or completely encapsulate a therapeutic agent, and may be nebulized for administration, such as by inhalation. In some embodiments, the therapeutic agent is mRNA.
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公开(公告)号:US20250051179A1
公开(公告)日:2025-02-13
申请号:US18929145
申请日:2024-10-28
Applicant: Oregon State University
Inventor: Munirpallam A. Subramanian , Jun Li , Yi-Chia Lin
IPC: C01G31/00
Abstract: Novel compounds having a thortveitite-related structure are disclosed. The compounds may be colored and may be useful as pigments. The compounds are durable with respect to an acid stability test that indicates that the pigments will not substantially change color when exposed to weak acids, such as rain. The compounds disclosed herein typically inexpensive to synthesize from earth-abundant, environmentally-friendly elements or minerals, and therefore are advantageous over existing pigments in the art.
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公开(公告)号:US20250020478A1
公开(公告)日:2025-01-16
申请号:US18349569
申请日:2023-07-10
Applicant: Oregon State University
Inventor: David Hamilton
Abstract: Briefly, embodiments, such as estimating energy utilization based at least in part on estimated regenerative energy production to select one or more preferred routes for an electric vehicle out of a network of routes, for example, are described.
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公开(公告)号:US20240425467A1
公开(公告)日:2024-12-26
申请号:US18815249
申请日:2024-08-26
Applicant: OREGON STATE UNIVERSITY
Inventor: Ryan A. Mehl , Robert Blizzard
IPC: C07D257/08 , C07D257/10 , C07K14/435 , C09B57/00 , C12N9/00 , C12Q1/25
Abstract: Tetrazine non-canonical amino acids, methods for genetic encoding proteins and polypeptides using the tetrazine amino acids, proteins and polypeptides comprising the tetrazine amino acids, and compositions comprising the proteins and polypeptides having at least one post-translational modification thereof comprising in vivo reaction with the incorporated tetrazine amino acid and a second molecule.
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公开(公告)号:US20240409875A1
公开(公告)日:2024-12-12
申请号:US18731842
申请日:2024-06-03
Applicant: K2 Biomicrosystems LLC , Oregon State University
Inventor: David P. Klemer , Melodie L. Putnam , Jeffrey H. Chang , Michael I. Gordon
Abstract: The present invention relates generally to the incorporation of a shroud into an apparatus which achieves tissue and/or cellular disruption through the imposition of a time-varying electromagnetic field generated by electrical means and used to direct magnetic beads or other magnetic particles against a tissue sample. Incorporation of the shroud allows for variation of temperature and/or pressure in the vicinity of the tissue sample during the tissue disruption process.
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公开(公告)号:US20240391961A1
公开(公告)日:2024-11-28
申请号:US18686249
申请日:2022-08-25
Applicant: Oregon State University
Inventor: Richard B. Cooley , Ryan A. Mehl , Phillip Zhu
Abstract: Embodiments of the present disclosure provide compositions and methods for biosynthesizing a stable, functional mimic of phosphoserine. The compositions and methods described herein genetically program a host cell to express a biosynthetic pathway that can synthesize the amino acid, 2-amino-4-phosphobobutyric acid, that is a non-hydrolyzable phosphoserine (nhpSer) because it contains a carbon-phosphorus, e.g., phosphonate, bond. In one embodiment the genetically programed cells express the enzymes of a pathway from a Streptomyces bacterium. In some embodiments, nhpSer is translationally incorporated into protein of interest at one or more programmed UAG amber codons using Genetic Code Expansion (GCE) technology.
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公开(公告)号:US20240380408A9
公开(公告)日:2024-11-14
申请号:US18485939
申请日:2023-10-12
Applicant: Washington University , Oregon State University
Inventor: Aravind Nagulu , Shantanu Chakrabartty , Arun Natarajan
IPC: H03M1/12
Abstract: A non-multiply-accumulate (non-MAC) charge-based analog correlator system including a sampler circuit block, an operand generation circuit block, and a margin propagation (MP) correlation computation circuit block is disclosed. The sampler circuit block is configured to sample a plurality of input analog signals. The operand generation circuit block is configured to generate operands based on the sampled plurality of input analog signals, and the margin propagation (MP) correlation computation circuit block is configured to generate correlated output signals based on the operands and using calculations in a charge domain.
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公开(公告)号:US20240270647A1
公开(公告)日:2024-08-15
申请号:US18442689
申请日:2024-02-15
Applicant: Purdue Research Foundation , Oregon State University
Inventor: Jeffrey Paul Youngblood , Jason Weiss , Krishna Siva Teja Chopperla , Sivakumar Ramanathan
IPC: C04B24/38 , C04B20/10 , C04B28/04 , C04B103/10
CPC classification number: C04B24/386 , C04B20/1022 , C04B20/1037 , C04B20/1048 , C04B20/1074 , C04B28/04 , C04B2103/10
Abstract: Cement paste compositions including modified cellulose nanomaterials such as modified cellulose nanocrystals and modified cellulose nanofibers, are disclosed herein. In some embodiments, the cement paste compositions include from about 0.005 volume % to about 1.5 volume % modified cellulose nanomaterial.
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公开(公告)号:USPP35894P2
公开(公告)日:2024-07-02
申请号:US18214058
申请日:2023-06-26
Applicant: Oregon State University
Inventor: Ryan N. Contreras
Abstract: A new Vaccinium ovatum plant distinguished by its upright and vigorous, yet compact growth habit, dense branching, and DNA content (tetraploid).
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公开(公告)号:USPP35866P2
公开(公告)日:2024-06-11
申请号:US18113485
申请日:2023-02-23
Applicant: Oregon State University
Inventor: Ryan N. Contreras
Abstract: A new and distinct Hibiscus plant cultivar named ‘ORSTHIB5X1’ is disclosed, characterized by its growth habit and form, deep green foliage that is resistant to chlorosis, seedlessness, and pentaploid chromosome complement.
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