公开(公告)号：US20090007904A1

公开(公告)日：2009-01-08

申请号：US11576441

申请日：2005-10-12

Applicant: Jeffrey A. Schuster ,  Peter Holst

Inventor： Jeffrey A. Schuster ,  Peter Holst

IPC: A61M11/00

CPC classification number: A61M11/02 ,  A61K9/0073 ,  A61K9/0078 ,  A61M11/005 ,  A61M15/0016 ,  A61M15/0065 ,  A61M2016/0027 ,  A61M2016/003 ,  A61M2205/27 ,  A61M2205/583 ,  A61M2205/8225

Abstract: A drug delivery device containing a sterile multi dose reservoir. Said sterile reservoir can be used with many types of delivery including injectors or aerosol drug delivery systems. Elevated pressure surrounding the reservoir is used during storage to ensure sterility is maintained. Mechanisms to prevent delivery in the case of potential compromise of sterility are disclosed. A device using the pressure to meter formulation from the reservoir is disclosed.

Abstract translation: 含有无菌多剂量储存器的药物递送装置。 所述无菌容器可以与许多类型的输送一起使用，包括注射器或气溶胶药物递送系统。 在储存期间使用围绕储存器的高压，以确保不育保持。 公开了在潜在危害不育的情况下防止分娩的机制。 公开了一种使用压力来计量储存器配方的装置。

公开(公告)号：US20050235733A1

公开(公告)日：2005-10-27

申请号：US11157758

申请日：2005-06-21

Applicant: Peter Holst ,  David Krajewski ,  Rudolph Maske

Inventor： Peter Holst ,  David Krajewski ,  Rudolph Maske

IPC: F04B49/08 ,  A61M5/00 ,  A61M5/142 ,  A61M5/168 ,  A61M5/172 ,  F04B13/00 ,  F04B49/00 ,  F04B49/06 ,  G01P21/00 ,  G05D16/20

CPC classification number: A61M5/14224 ,  A61M5/16809 ,  A61M5/16827 ,  A61M5/365 ,  A61M2205/12 ,  A61M2205/3355 ,  A61M2205/50 ,  G05D16/2046

Abstract: A pump used to infuse a fluid into a patient is controlled in accordance with an algorithm that enables a microprocessor to monitor and adjust each pump cycle to compensate for a differential pressure between the pump's inlet and outlet. The algorithm defines a fluid delivery protocol that is applied in controlling the operation of the pump to achieve a desired rate, volume, and timing of the fluid infusion. Fluid is delivered by the pump when a plunger compresses an elastomeric membrane overlying a fluid chamber. Due to the small volume of the chamber, an incremental change in the plunger position before the delivery stroke produces a significant change in the delivery pressure. At the beginning of a pump cycle, the microprocessor determines the differential pressure between the inlet and outlet of the pump, and adjusts the plunger position before the delivery stroke to compensate for the differential pressure. A retraction of the plunger from the home position decreases the delivery pressure of the fluid, and an advancement of the plunger increases it. After the position of the plunger is adjusted to compensate for the differential pressure, the pump cycle proceeds. Following the plunger stroke, the outlet pressure is used to determine the actual volume of fluid delivered. The duration of the plunger stroke in the next pump cycle is adjusted to compensate for any volume delivery error produced by the differential pressure compensation.

Abstract translation: 用于将流体注入患者体内的泵根据能够使微处理器监测和调节每个泵循环以补偿泵的入口和出口之间的压差的算法来控制。 该算法定义了流体输送协议，其被应用于控制泵的操作以实现流体输注的期望速率，体积和时间。 当柱塞压缩覆盖流体室的弹性体膜时，流体由泵输送。 由于室的体积小，在输送冲程之前的柱塞位置的增量变化产生输送压力的显着变化。 在泵循环开始时，微处理器确定泵的入口和出口之间的压差，并在输送冲程之前调节柱塞位置，以补偿差压。 柱塞从原始位置的缩回减小了流体的输送压力，并且柱塞的前进增加了其。 在调节柱塞的位置以补偿差压之后，泵循环进行。 在柱塞行程之后，出口压力用于确定输送的流体的实际体积。 在下一个泵循环中的柱塞行程的持续时间被调整以补偿由差压补偿产生的任何体积传递误差。

公开(公告)号：US20130114796A1

公开(公告)日：2013-05-09

申请号：US13291804

申请日：2011-11-08

Applicant: TOBIAS FUNK ,  BRIAN WILFLEY ,  PETER HOLST

Inventor： TOBIAS FUNK ,  BRIAN WILFLEY ,  PETER HOLST

IPC: G21K1/02

CPC classification number: G21K1/025

Abstract: An x-ray collimator can be constructed from multiple subassemblies, which at least includes a first subassembly that reduces the leakage of x-ray radiation between adjacent apertures and a second subassembly that reduces the spill of x-ray radiation around the detector face. Each of these subassemblies has numerous apertures. In the first subassembly these apertures correspond to focal spots on an x-ray source, and in the second subassembly, these apertures are shaped such that the dimensions increase from smaller entrances to larger exits.

Abstract translation: x射线准直仪可以由多个子组件构成，其至少包括第一子组件，其减少相邻孔之间的x射线辐射的泄漏，以及减少X射线辐射在检测器面周围的溢出的第二子组件。 这些子组件中的每一个具有许多孔。 在第一子组件中，这些孔对应于x射线源上的焦点，并且在第二子组件中，这些孔被成形为使得尺寸从较小的入口增加到较大的出口。

公开(公告)号：US20050238497A1

公开(公告)日：2005-10-27

申请号：US11157755

申请日：2005-06-21

Applicant: Peter Holst ,  David Krajewski ,  Rudolph Maske

Inventor： Peter Holst ,  David Krajewski ,  Rudolph Maske

IPC: F04B49/08 ,  A61M5/00 ,  A61M5/142 ,  A61M5/168 ,  A61M5/172 ,  F04B13/00 ,  F04B49/00 ,  F04B49/06 ,  G01P21/00 ,  G05D16/20

CPC classification number: A61M5/14224 ,  A61M5/16809 ,  A61M5/16827 ,  A61M5/365 ,  A61M2205/12 ,  A61M2205/3355 ,  A61M2205/50 ,  G05D16/2046

Abstract: A pump used to infuse a fluid into a patient is controlled in accordance with an algorithm that enables a microprocessor to monitor and adjust each pump cycle to compensate for a differential pressure between the pump's inlet and outlet. The algorithm defines a fluid delivery protocol that is applied in controlling the operation of the pump to achieve a desired rate, volume, and timing of the fluid infusion. Fluid is delivered by the pump when a plunger compresses an elastomeric membrane overlying a fluid chamber. Due to the small volume of the chamber, an incremental change in the plunger position before the delivery stroke produces a significant change in the delivery pressure. At the beginning of a pump cycle, the microprocessor determines the differential pressure between the inlet and outlet of the pump, and adjusts the plunger position before the delivery stroke to compensate for the differential pressure. A retraction of the plunger from the home position decreases the delivery pressure of the fluid, and an advancement of the plunger increases it. After the position of the plunger is adjusted to compensate for the differential pressure, the pump cycle proceeds. Following the plunger stroke, the outlet pressure is used to determine the actual volume of fluid delivered. The duration of the plunger stroke in the next pump cycle is adjusted to compensate for any volume delivery error produced by the differential pressure compensation.

Abstract translation: 用于将流体注入患者体内的泵根据能够使微处理器监测和调节每个泵循环以补偿泵的入口和出口之间的压差的算法来控制。 该算法定义了流体输送协议，其被应用于控制泵的操作以实现流体输注的期望速率，体积和时间。 当柱塞压缩覆盖流体室的弹性体膜时，流体由泵输送。 由于室的体积小，在输送冲程之前的柱塞位置的增量变化产生输送压力的显着变化。 在泵循环开始时，微处理器确定泵的入口和出口之间的压差，并在输送冲程之前调节柱塞位置，以补偿差压。 柱塞从原始位置的缩回减小了流体的输送压力，并且柱塞的前进增加了其。 在调节柱塞的位置以补偿差压之后，泵循环进行。 在柱塞行程之后，出口压力用于确定输送的流体的实际体积。 在下一个泵循环中的柱塞行程的持续时间被调整以补偿由差压补偿产生的任何体积传递误差。

公开(公告)号：US20070256688A1

公开(公告)日：2007-11-08

申请号：US11737655

申请日：2007-04-19

Applicant: Jeffrey Schuster ,  Peter Holst ,  Brian Ament ,  Keith Bogdon

Inventor： Jeffrey Schuster ,  Peter Holst ,  Brian Ament ,  Keith Bogdon

IPC: A61M11/00

CPC classification number: A61M15/0028 ,  A61M15/0031 ,  A61M15/0081 ,  A61M2202/064

Abstract: Devices for delivering an aerosolized drug formulation and methods for using such devices are herein provided. Specifically, the invention relates to a drug delivery device that contains a drug formulation and an actuator for aerosolizing the formulation in preparation for drug delivery. The drug delivery devices of the invention are configured for delivering a single dose of an active agent (e.g., a pharmaceutical compound) or a mixture of multiple active agents and may further be configured so as to be hand-held, self-contained, portable and disposable. Methods of treatment and drugs that are suitable for use in the subject devices are also disclosed.

Abstract translation: 本文提供了用于递送雾化药物制剂的装置和使用这种装置的方法。 具体地，本发明涉及一种药物递送装置，其包含药物制剂和用于在制备药物递送中使制剂雾化的致动器。 本发明的药物递送装置被配置用于递送单剂量的活性剂（例如，药物化合物）或多种活性剂的混合物，并且还可以被配置为手持式，独立型，便携式 和一次性。 还公开了适用于本发明装置的治疗方法和药物。

公开(公告)号：US06689722B1

公开(公告)日：2004-02-10

申请号：US10176227

申请日：2002-06-20

Applicant: David Peter Holst-Grubbe ,  Maurice Leroy Oyanadel

Inventor： David Peter Holst-Grubbe ,  Maurice Leroy Oyanadel

IPC: C10M12522

CPC classification number: C10M169/04 ,  C10M2201/065 ,  C10M2207/283 ,  C10M2207/401 ,  C10N2210/06 ,  C10N2220/082 ,  C10N2230/06 ,  C10N2230/64 ,  C10N2240/401 ,  C10N2270/00

Abstract: An environmentally safe lubricating composition comprising a suspension of submicron molybdenum disulfide in canola oil is disclosed. Preferably the canola oil comprises trimethylol propane trioleate ester. In combining the molybdenum disulfide with the canola oil it preferred that the high shear mixing occur in the presence of a magnetic field.

Abstract translation: 公开了一种环境安全的润滑组合物，其包含二羧基二硫化碳在卡诺拉油中的悬浮液。 优选地，卡诺拉油包含三羟甲基丙烷三油酸酯。 在将二硫化钼与卡诺拉油组合时，优选在存在磁场的情况下进行高剪切混合。

公开(公告)号：US09257207B2

公开(公告)日：2016-02-09

申请号：US13291804

申请日：2011-11-08

Applicant: Tobias Funk ,  Brian Wilfley ,  Peter Holst

Inventor： Tobias Funk ,  Brian Wilfley ,  Peter Holst

IPC: G21K1/02

CPC classification number: G21K1/025

Abstract: An x-ray collimator can be constructed from multiple subassemblies, which at least includes a first subassembly that reduces the leakage of x-ray radiation between adjacent apertures and a second subassembly that reduces the spill of x-ray radiation around the detector face. Each of these subassemblies has numerous apertures. In the first subassembly these apertures correspond to focal spots on an x-ray source, and in the second subassembly, these apertures are shaped such that the dimensions increase from smaller entrances to larger exits.

Abstract translation: x射线准直仪可以由多个子组件构成，其至少包括第一子组件，其减少相邻孔之间的x射线辐射的泄漏，以及减少X射线辐射在检测器面周围的溢出的第二子组件。 这些子组件中的每一个具有许多孔。 在第一子组件中，这些孔对应于x射线源上的焦点，并且在第二子组件中，这些孔被成形为使得尺寸从较小的入口增加到较大的出口。