公开(公告)号：US20110045481A1

公开(公告)日：2011-02-24

申请号：US12864581

申请日：2009-01-23

Applicant: Patrick Gladding ,  Arzu Gunes ,  Marja-Liisa Dahl ,  Mark Webster

Inventor： Patrick Gladding ,  Arzu Gunes ,  Marja-Liisa Dahl ,  Mark Webster

IPC: C12Q1/68 ,  A61K31/4365 ,  A61P7/02 ,  G06F19/00

CPC classification number: A61K31/4365 ,  C12Q1/6827 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172

Abstract: The present invention provides methods for predicting or determining a subject's response to an antiplatelet agent, and methods for determining a subject's suitability to a treatment regime or intervention for a disease associated with platelet aggregation, using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's response to an antiplatelet agent. Nucleotide probes and primers, kits, and microarrays suitable for such assessment are also provided.

Abstract translation: 本发明提供用于预测或确定受试者对抗血小板药物的反应的方法，以及使用遗传多态性分析确定受试者对与血小板聚集相关的疾病的治疗方案或干预的适用性的方法。 本发明还涉及遗传多态性在评估受试者对抗血小板药物的反应中的用途。 还提供了适用于这种评估的核苷酸探针和引物，试剂盒和微阵列。