公开(公告)号：US20050038249A1

公开(公告)日：2005-02-17

申请号：US10928595

申请日：2004-08-30

Applicant: William Denny ,  William Wilson ,  David Ware ,  Graham Atwell ,  Jared Milbank ,  Ralph Stevenson

Inventor： William Denny ,  William Wilson ,  David Ware ,  Graham Atwell ,  Jared Milbank ,  Ralph Stevenson

IPC: C07D215/30 ,  A61K31/404 ,  A61K31/437 ,  A61K31/47 ,  A61P35/00 ,  A61P43/00 ,  C07D209/60 ,  C07D255/02 ,  C07D257/00 ,  C07D257/02 ,  C07D471/04 ,  C07F11/00 ,  C07F15/06 ,  C07F15/00

CPC classification number: C07D471/04 ,  C07D257/00 ,  C07F11/005 ,  C07F15/065

Abstract: This invention relates to a class of heterocycles and their metal complexes, and is particularly concerned with the use of these compounds in the preparation of prodrugs or as prodrugs that may be activated under hypoxic conditions by enzymes or by therapeutic ionising radiation, in the treatment of cancer. The invention also relates to the use of these heterocycles and the corresponding metal complexes in the preparation of medicaments and to compositions including the heterocycles or their metal complexes and to methods for preparing these compounds.

Abstract translation: 本发明涉及一类杂环及其金属络合物，特别涉及这些化合物在制备前体药物中的用途，或作为可在缺氧条件下通过酶或通过治疗电离辐射活化的前药，用于治疗 癌症。 本发明还涉及这些杂环和相应的金属络合物在制备药物中的用途以及包括杂环或其金属络合物的组合物以及制备这些化合物的方法。