公开(公告)号：US06579862B1

公开(公告)日：2003-06-17

申请号：US09280448

申请日：1999-03-30

Applicant: Ram Pratap ,  Ram Chandra Gupta ,  Ramesh Chander ,  Ashok Kumar Khanna ,  Arvind Kumar Srivastava ,  Deepak Raina ,  Satyavan Singh ,  Savita Srivastava ,  Anil Kumar Rastogi ,  Omkar Prasad Asthana ,  Swarn Nityanand ,  Nitya Anand ,  Ashim Ghatak ,  Narinder Kumar Kapoor ,  Sukh Dev

Inventor： Ram Pratap ,  Ram Chandra Gupta ,  Ramesh Chander ,  Ashok Kumar Khanna ,  Arvind Kumar Srivastava ,  Deepak Raina ,  Satyavan Singh ,  Savita Srivastava ,  Anil Kumar Rastogi ,  Omkar Prasad Asthana ,  Swarn Nityanand ,  Nitya Anand ,  Ashim Ghatak ,  Narinder Kumar Kapoor ,  Sukh Dev

IPC: A61K3158

CPC classification number: A61K31/573 ,  C07J13/005 ,  C07J13/007

Abstract: The invention provides a method of using pregnadienones and pregnadienols represented by the structural formula (I): containing at least one olefinic bond in or on their D-ring for the treatment of hyperlipidemic and hyperglycemic conditions in mammals wherein X═OH or O and the olefinic bonds are at 4(5); 5(6); 16(17); or 17(20) or various combinations, and wherein the compounds contain at lest one olefinic bond in or on their D-ring. The method comprises administering an effective amount of said compounds to recipient mammals.

Abstract translation: 本发明提供了一种使用由结构式（I）表示的孕ad酮和孕二烯醇的方法：在D环中或其D环上含有至少一个烯键，用于治疗哺乳动物中的高脂血症和高血糖病症，其中X = OH或O， 烯键为4（5）; 5（6）; 16（17）; 或17（20）或各种组合，并且其中所述化合物在其D环中或其上含有至少一个烯键。 该方法包括向受体哺乳动物施用有效量的所述化合物。

公开(公告)号：US20060142303A1

公开(公告)日：2006-06-29

申请号：US11018923

申请日：2004-12-22

Applicant: Ram Pratap ,  Mavurapu Satyanarayana ,  Chandeshwar Nath ,  Ram Raghubir ,  Anju Puri ,  Ramesh Chander ,  Priti Tiwari ,  Brajendra Tripathi ,  Arvind Srivastava

Inventor： Ram Pratap ,  Mavurapu Satyanarayana ,  Chandeshwar Nath ,  Ram Raghubir ,  Anju Puri ,  Ramesh Chander ,  Priti Tiwari ,  Brajendra Tripathi ,  Arvind Srivastava

IPC: A61K31/496 ,  A61K31/426

CPC classification number: C07D295/092 ,  C07D277/34 ,  C07D317/54 ,  C07D417/12

Abstract: The present invention provides novel substituted chalcone derivatives which exhibit anti-hyperglycemic and anti-dyslipedemic activity. The invention also provides a method for treating type II diabetes and associated hyperlipidemic conditions in a mammal by administering the compounds of the present invention and compositions containing these derivatives.

Abstract translation: 本发明提供了具有抗高血糖和抗血脂异常活性的新型取代查耳酮衍生物。 本发明还提供了通过施用本发明的化合物和含有这些衍生物的组合物来治疗哺乳动物II型糖尿病和相关高脂血症的方法。

公开(公告)号：US6086889A

公开(公告)日：2000-07-11

申请号：US263204

申请日：1999-03-05

Applicant: Santosh Kumar Agarwal ,  Tajuddin ,  Mohammad Shafiq Siddiqui ,  Sushil Kumar ,  Ashok Kumar Khanna ,  Ramesh Chander

Inventor： Santosh Kumar Agarwal ,  Tajuddin ,  Mohammad Shafiq Siddiqui ,  Sushil Kumar ,  Ashok Kumar Khanna ,  Ramesh Chander

IPC: A61K31/57 ,  A61K36/328 ,  C07J13/00

CPC classification number: A61K31/57 ,  A61K36/328 ,  C07J13/007 ,  A61K2236/39

Abstract: A process for the isolation of a lipid fraction containing Z & E guggulsterones useful as cholesterol lowering drug, which comprises soaking/soxhlet extracting the powdered aerial part of the plant C. wightii with a non polar solvent, filtering/deanting the extract, soaking the material again in a polar solvent, filtering and concentrating the extracted material under reduced pressure as to obtain a thick viscous extract, and subjecting the thick viscous extract to gel filteration/silica gel chromatography to obtain Z & E ketosteroid containing lipid fraction exhibiting hypolipidemic activity.

Abstract translation: 一种用于分离含有用作胆固醇降低药物的Z＆E格鲁酮的脂质部分的方法，其包括用非极性溶剂浸提/索格利特提取植物C.Wightii的粉状地上部分，过滤/倾斜提取物，浸泡 在极性溶剂中再次过滤并浓缩提取的材料，以获得稠粘稠的提取物，并将稠粘稠的提取物进行凝胶过滤/硅胶色谱，得到含有降脂活性的含有类固醇的脂质组分。

公开(公告)号：US5753258A

公开(公告)日：1998-05-19

申请号：US134156

申请日：1993-10-08

Applicant: Hans Schreier ,  Ramesh Chander ,  Arlene A. Stecenko

Inventor： Hans Schreier ,  Ramesh Chander ,  Arlene A. Stecenko

IPC: A61K9/127 ,  A61K9/133

CPC classification number: A61K9/1271 ,  A61K9/1277 ,  Y10S424/812 ,  Y10S436/829

Abstract: The production of artificial viral envelopes by a novel double-detergent dialysis technique is disclosed. Specifically exemplified is the production of HIV-1 and RSV viral envelopes. The resulting artificial viral envelopes are essentially identical to the natural virus with regard to characteristics which are relevant to immunogenicity and interacellular transfer of encapsulated material.

Abstract translation: 公开了通过新型双洗涤剂透析技术生产人造病毒包膜。 具体举例说明了HIV-1和RSV病毒包膜的产生。 关于与包封材料的免疫原性和细胞间转移相关的特征，所得到的人造病毒包膜基本上与天然病毒相同。

公开(公告)号：US5145955A

公开(公告)日：1992-09-08

申请号：US783410

申请日：1991-10-28

Applicant: Bacchan S. Aswal ,  Ramesh Chander ,  Sunil K. Chatterji ,  Bhola N. Dhawan ,  Yogesh Dwivedi ,  Narendra K. Garg ,  Poonam Jain ,  Narinder K. Kapoor ,  Dinesh K. Kulshreshtha ,  Bishan N. Mehrotra ,  Gyanendra K. Patnaik ,  Ravi Rastogi ,  Jagat P. S. Sarin ,  Krishna C. Saxena ,  Shekhar C. Sharma ,  Shri K. Sharma ,  Binduja Shukla ,  Pradeep K. S. Visen

Inventor： Bacchan S. Aswal ,  Ramesh Chander ,  Sunil K. Chatterji ,  Bhola N. Dhawan ,  Yogesh Dwivedi ,  Narendra K. Garg ,  Poonam Jain ,  Narinder K. Kapoor ,  Dinesh K. Kulshreshtha ,  Bishan N. Mehrotra ,  Gyanendra K. Patnaik ,  Ravi Rastogi ,  Jagat P. S. Sarin ,  Krishna C. Saxena ,  Shekhar C. Sharma ,  Shri K. Sharma ,  Binduja Shukla ,  Pradeep K. S. Visen

IPC: A61K36/80 ,  C07H17/04

CPC classification number: C07H17/04 ,  A61K36/80 ,  Y10S514/893 ,  Y10S514/894

Abstract: The present invention describes a process for the preparation of a fraction, mainly containing picroside I and kurrooa, from the plant Picrorhiza kurrooa.

Abstract translation: 本发明描述了用于制备主要含有赤霉素（I）和赤藓红（Kurrooa）的级分的方法。

公开(公告)号：US08419107B2

公开(公告)日：2013-04-16

申请号：US13255933

申请日：2010-03-29

Applicant: Ramesh Chander Manchanda

Inventor： Ramesh Chander Manchanda

IPC: B60J11/04

CPC classification number: B60J11/06

Abstract: A retractable vehicle shade is provided for vehicles which includes a hollow central box, a front sliding panel, and a rear sliding panel. The hollow central box is mounted on a rooftop of the vehicle. The front sliding panel is slidingly fitted into the box through a slot at the front end and configured to cover at least front glass pane. The rear sliding panel is slidingly fitted into the box through the slot at the rear end and configured to cover at least rear glass pane. The vehicle shade can further include a detach-ably attached water-proof stretchable fabric member for providing a datable layer over respective panels and central box. The fabric member has one or more elastic members which causes it to fold up along the end portions of the sliding panels on the top of box, when the panels are retracted backwards into the box.

Abstract translation: 为包括中空中心箱，前滑动面板和后滑动面板的车辆提供可伸缩车辆遮光罩。 中空中央箱被安装在车辆的屋顶上。 前滑动面板通过前端的槽滑动地装配到箱中，并且构造成至少覆盖前玻璃板。 后滑动面板通过后端的槽滑动装配到箱体中，并配置成至少覆盖后玻璃板。 车辆遮光罩可以进一步包括一个可拆卸的防水伸缩织物，用于在相应的面板和中央盒上提供一个可伸缩层。 织物构件具有一个或多个弹性构件，当弹性构件向后缩进箱体时，弹性构件沿着盒子顶部的滑动面板的端部折叠。

公开(公告)号：US07635779B2

公开(公告)日：2009-12-22

申请号：US11052833

申请日：2005-02-09

Applicant: Ram Pratap ,  Mavurapu Satyanarayana ,  Chandeshwar Nath ,  Ram Raghubir ,  Anju Puri ,  Ramesh Chander ,  Priti Tiwari ,  Brajendra Kumar Tripathi ,  Arvind Kumar Srivastava

Inventor： Ram Pratap ,  Mavurapu Satyanarayana ,  Chandeshwar Nath ,  Ram Raghubir ,  Anju Puri ,  Ramesh Chander ,  Priti Tiwari ,  Brajendra Kumar Tripathi ,  Arvind Kumar Srivastava

IPC: C07D311/30

CPC classification number: C07D417/12 ,  C07D311/30

Abstract: The present invention provides novel substituted flavone derivatives which exhibit anti-hyperglycemic and antidyslipedemic activity. The invention also provides a method for controlling type II diabetes and associated hyperlipidemic conditions in a mammal by administering compound of the present invention and compositions containing these derivatives.

Abstract translation: 本发明提供了具有抗高血糖和抗血脂活性的新型取代黄酮衍生物。 本发明还提供了一种通过施用本发明的化合物和含有这些衍生物的组合物来控制哺乳动物II型糖尿病和相关高脂血症的方法。

公开(公告)号：US20060178373A1

公开(公告)日：2006-08-10

申请号：US11052833

申请日：2005-02-09

Applicant: Ram Pratap ,  Mavurapu Satyanarayana ,  Chandeshwar Nath ,  Ram Raghubir ,  Anju Puri ,  Ramesh Chander ,  Priti Tiwari ,  Brajendra Tripathi ,  Arvind Srivastava

Inventor： Ram Pratap ,  Mavurapu Satyanarayana ,  Chandeshwar Nath ,  Ram Raghubir ,  Anju Puri ,  Ramesh Chander ,  Priti Tiwari ,  Brajendra Tripathi ,  Arvind Srivastava

IPC: A61K31/496 ,  A61K31/427 ,  A61K31/353 ,  C07D417/02 ,  C07D405/02

CPC classification number: C07D417/12 ,  C07D311/30

Abstract: The present invention provides novel substituted flavone derivatives which exhibit anti-hyperglycemic and antidyslipedemic activity. The invention also provides a method for controlling type II diabetes and associated hyperlipidemic conditions in a mammal by administering compound of the present invention and compositions containing these derivatives.

公开(公告)号：US5766625A

公开(公告)日：1998-06-16

申请号：US474814

申请日：1995-06-07

Applicant: Hans Schreier ,  Ramesh Chander ,  Arlene A. Stecenko

Inventor： Hans Schreier ,  Ramesh Chander ,  Arlene A. Stecenko

IPC: A61K9/127 ,  A61K9/133

CPC classification number: A61K9/1271 ,  A61K9/1277 ,  Y10S424/812 ,  Y10S436/829

Abstract: The production of artificial viral envelopes by a novel double-detergent dialysis technique is disclosed. Specifically exemplified is the production of HIV-1 and RSV viral envelopes. The resulting artificial viral envelopes are essentially identical to the natural virus with regard to characteristics which are relevant to immunogenicity and intracellular transfer of encapsulated material.

Abstract translation: 公开了通过新型双洗涤剂透析技术生产人造病毒包膜。 具体举例说明了HIV-1和RSV病毒包膜的产生。 关于与包封材料的免疫原性和细胞内转移相关的特征，所得到的人造病毒包膜基本上与天然病毒相同。

公开(公告)号：US07807712B2

公开(公告)日：2010-10-05

申请号：US11018923

申请日：2004-12-22

Applicant: Ram Pratap ,  Mavurapu Satyanarayana ,  Chandeshwar Nath ,  Ram Raghubir ,  Anju Puri ,  Ramesh Chander ,  Priti Tiwari ,  Brajendra Kumar Tripathi ,  Arvind Kumar Srivastava

Inventor： Ram Pratap ,  Mavurapu Satyanarayana ,  Chandeshwar Nath ,  Ram Raghubir ,  Anju Puri ,  Ramesh Chander ,  Priti Tiwari ,  Brajendra Kumar Tripathi ,  Arvind Kumar Srivastava

IPC: A61K31/36 ,  A61K31/427 ,  A61K31/085 ,  C07D317/06 ,  C07C49/105 ,  C07C49/11 ,  A61P3/10 ,  A61P9/10

CPC classification number: C07D295/092 ,  C07D277/34 ,  C07D317/54 ,  C07D417/12

Abstract: The present invention provides appropriately substituted chalcones, such as, for example, represented by the structural formula as shown herein below Wherein R1, R2 and R3 are selected from the group consisting of H, OH, O-alkyl, O-phenyl and O-substituted phenyl; B represents Ar—Z—O or RO; where Z is an alkane having up to 5 carbon atoms; R is substituted propanol amino, wherein substituted amino groups are selected from the group consisting of t-butyl, n-butyl, i-butyl, i-propyl, 4-phenyl piperazine-1-yl, 4-(2-methoxyphenyl)-piperazin-1-yl and 3,4-dimethoxy phenethyl; and Ar is thiazolidine-dione methylene phenoxy. The compounds prepared have been demonstrated to exhibit significant antidiabetic effect in various animal models indicating potential for further exploitation.

Abstract translation: 本发明提供适当取代的查尔酮，例如由如下文所示的结构式表示，其中R1，R2和R3选自H，OH，O-烷基，O-苯基和O- 取代的苯基; B表示Ar-Z-O或RO; 其中Z是具有至多5个碳原子的烷烃; R是取代的丙醇氨基，其中取代的氨基选自叔丁基，正丁基，异丁基，异丙基，4-苯基哌嗪-1-基，4-（2-甲氧基苯基） - 哌嗪-1-基和3,4-二甲氧基苯乙基; Ar是噻唑烷二酮亚甲基苯氧基。 已经证明所制备的化合物在各种动物模型中表现出显着的抗糖尿病作用，表明有可能进一步开发。