公开(公告)号：US12070475B2

公开(公告)日：2024-08-27

申请号：US16970861

申请日：2019-02-22

Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education ,  Ri.MED Foundation

Inventor： Riccardo Luca Gottardi ,  Benjamin Burke Rothrauff ,  Rocky Sung Chi Tuan ,  Shinsuke Kihara

IPC: A61K36/00 ,  A61K9/19 ,  A61K35/32 ,  A61K47/18

CPC classification number: A61K35/32 ,  A61K9/19 ,  A61K47/18

Abstract: Provided herein is a ligament ECM soluble fraction useful for the growth and regrowth of ligament tissue. Methods of preparation of the soluble fractions and use of the soluble fractions in growth or regrowth of ligament tissue also are provided.

公开(公告)号：US20210236688A1

公开(公告)日：2021-08-05

申请号：US17050538

申请日：2019-04-25

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education ,  Ri.MED Foundation ,  University of Cincinnati

Inventor： William R. Wagner ,  Antonio D'Amore ,  Vesselin N. Shanov

IPC: A61L27/04 ,  A61F2/24 ,  A61L27/18 ,  A61L27/58 ,  A61L27/34 ,  A61L33/06 ,  A61L33/00 ,  C08L75/04 ,  C08L65/04

Abstract: Provided herein is a prosthetic heart valve device including a biocompatible and biodegradable metal frame comprising a proximal end, a distal end, and a sidewall therebetween, the sidewall having a plurality of openings therethrough. The device further includes a biocompatible and biodegradable polymeric heart valve having an annular portion attached at least one contact point to the proximal end of the frame and at least one leaflet attached to and extending distally from the annular portion.

公开(公告)号：US12280195B2

公开(公告)日：2025-04-22

申请号：US16485240

申请日：2018-02-12

Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education ,  Ri.MED Foundation

Inventor： Vinay Badhwar ,  Antonio D'Amore ,  Daniel McKeel ,  William R. Wagner

IPC: A61M1/36

Abstract: Provided herein is a percutaneous expandable venous cannula device, and related methods. The device is easily inserted, for example, using standard Seldinger technique via the right internal jugular. The device includes multiple, multi-holed limbs that softly fill, e.g., the right atrium to facilitate complete drainage, enable retraction of the chamber in surgery, and mitigate suction occlusion, filling the entire atrium and allowing for efficient and rapid emptying of the chamber. In aspects, the device facilitates minimally-invasive aortic or mitral valve surgery with single placement via the right internal jugular as the sole cannula needed for full support.

公开(公告)号：US20200010979A1

公开(公告)日：2020-01-09

申请号：US16494797

申请日：2018-03-16

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education ,  Ri.MED Foundation

Inventor： Antonio D'Amore ,  William R. Wagner

IPC: D01D5/00 ,  A61L27/18 ,  A61F2/24

Abstract: A system and method are provided for manufacturing filamentous polymer matrices, comprising electrospinning a polymer fiber into a gap between two or more spaced-apart electrodes.

公开(公告)号：US12077885B2

公开(公告)日：2024-09-03

申请号：US17627414

申请日：2020-07-15

Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education ,  Ri.MED Foundation

Inventor： Antonio D'Amore ,  Daniel McKeel ,  William R. Wagner

IPC: D02G3/26 ,  A61F2/24 ,  D01D5/00 ,  D02G3/02 ,  D02G3/36 ,  D02G3/44 ,  D07B1/02 ,  D07B3/00

CPC classification number: D02G3/26 ,  D01D5/0076 ,  D02G3/02 ,  D02G3/36 ,  D02G3/448 ,  D07B1/02 ,  D07B3/00 ,  A61F2/2457 ,  D07B2201/104 ,  D07B2201/2057 ,  D07B2201/2066 ,  D07B2201/2092 ,  D07B2205/2039 ,  D07B2205/2064 ,  D10B2331/10 ,  D10B2509/04

Abstract: Provided herein is an electrodeposition apparatus for producing long polymeric threads, yarns, or ropes. A method of preparing long polymeric threads, yarns or ropes also is provided.

公开(公告)号：US20210386825A1

公开(公告)日：2021-12-16

申请号：US17460867

申请日：2021-08-30

Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  Ri.MED Foundation

Inventor： Steven R. Little ,  Riccardo Gottardi ,  Mintai Peter Hwang ,  Daniel DeSantis

IPC: A61K38/18 ,  A61K38/19 ,  A61K9/50 ,  A61K38/30 ,  A61K35/28 ,  A61K9/127

Abstract: The present invention provides microparticles that induce the migration of multipotent stem cells to the anatomical site of the microparticles. Various release profiles are demonstrated that depend upon the relative concentration of alginate in the chemokine-loaded microparticle. Local administration and/or intraarticular injection of the microparticles are useful in conditions such as osteoarthritis. Targeted systemic delivery of the alginate chemokine microparticles to distant anatomical sites subjected to autoimmune disease symptomology can be performed by encapsulation within liposomes having targeting ligands. Consequently, upon the creation of the appropriate chemokine gradient, multipotent stem cells will migrate to the distant anatomical site where the liposomes are attached.

公开(公告)号：US20210085834A1

公开(公告)日：2021-03-25

申请号：US16634539

申请日：2018-07-26

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education ,  Ri.MED Foundation

Inventor： Antonio D'Amore ,  Matteo Solazzo ,  William R. Wagner

IPC: A61L31/04 ,  A61L33/00 ,  A61L31/12 ,  A61L31/16 ,  A61L31/14

Abstract: A multi-layer device is provided that is useful in tissue regeneration, for example, for vascular regeneration, e.g., for use in treatment of a coronary vascular disease, such as for treatment of myocardial infarction. A method of making the device also is provided.

公开(公告)号：US12178849B2

公开(公告)日：2024-12-31

申请号：US17460867

申请日：2021-08-30

Applicant: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  Ri.MED Foundation

Inventor： Steven R. Little ,  Riccardo Gottardi ,  Mintai Peter Hwang ,  Daniel DeSantis

IPC: A61K38/18 ,  A61K9/127 ,  A61K9/50 ,  A61K35/28 ,  A61K38/19 ,  A61K38/30

Abstract: The present invention provides microparticles that induce the migration of multipotent stem cells to the anatomical site of the microparticles. Various release profiles are demonstrated that depend upon the relative concentration of alginate in the chemokine-loaded microparticle. Local administration and/or intraarticular injection of the microparticles are useful in conditions such as osteoarthritis. Targeted systemic delivery of the alginate chemokine microparticles to distant anatomical sites subjected to autoimmune disease symptomology can be performed by encapsulation within liposomes having targeting ligands. Consequently, upon the creation of the appropriate chemokine gradient, multipotent stem cells will migrate to the distant anatomical site where the liposomes are attached.

公开(公告)号：US20240374650A1

公开(公告)日：2024-11-14

申请号：US18781328

申请日：2024-07-23

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education ,  Ri.MED Foundation

Inventor： Riccardo Luca Gottardi ,  Benjamin Burke Rothrauff ,  Rocky Sung Chi Tuan ,  Shinsuke Kihara

IPC: A61K35/32 ,  A61K9/19 ,  A61K47/18

Abstract: Provided herein is a ligament ECM soluble fraction useful for the growth and regrowth of ligament tissue. Methods of preparation of the soluble fractions and use of the soluble fractions in growth or regrowth of ligament tissue also are provided.

公开(公告)号：US20220259773A1

公开(公告)日：2022-08-18

申请号：US17627414

申请日：2020-07-15

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education ,  Ri.MED Foundation

Inventor： Antonio D'Amore ,  Daniel McKeel ,  William R. Wagner

IPC: D02G3/26 ,  D02G3/02 ,  D02G3/36 ,  D02G3/44 ,  D07B3/00 ,  D01D5/00 ,  D07B1/02

Abstract: Provided herein is an electrodeposition apparatus for producing long polymeric threads, yarns, or ropes. A method of preparing long polymeric threads, yarns or ropes also is provided.