公开(公告)号：US20100094407A1

公开(公告)日：2010-04-15

申请号：US12249594

申请日：2008-10-10

Applicant: Natividad Vasquez ,  Iskender Matt Bilge ,  Susan Rea Peterson

Inventor： Natividad Vasquez ,  Iskender Matt Bilge ,  Susan Rea Peterson

IPC: A61L27/54 ,  A61F2/82

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/45 ,  A61L2300/61

Abstract: The apparatus and methods of the present invention in a broad aspect provide novel multiple bioactive agent eluting stents for treating vascular diseases and conditions. Controlled elution of bioactive agents is achieved by the presence of the bioactive agents themselves. One or more characteristics of the bioactive agents cause variations in elution rates or profiles or the other bioactive agents.

Abstract translation: 本发明的装置和方法在广泛的方面提供了用于治疗血管疾病和病症的新型多重生物活性剂洗脱支架。 通过存在生物活性剂本身来实现生物活性剂的控制洗脱。 生物活性剂的一个或多个特征导致洗脱速率或轮廓或其他生物活性剂的变化。

公开(公告)号：US20090093871A1

公开(公告)日：2009-04-09

申请号：US11868742

申请日：2007-10-08

Applicant: Susan Rea ,  Feridun Ozdil ,  Robert Rajalingam ,  Noreen F. Moloney ,  Jeffrey Allen ,  Matthew J. Birdsall ,  Darrel Untereker ,  Jeffrey Gross ,  Mark Dolan

Inventor： Susan Rea ,  Feridun Ozdil ,  Robert Rajalingam ,  Noreen F. Moloney ,  Jeffrey Allen ,  Matthew J. Birdsall ,  Darrel Untereker ,  Jeffrey Gross ,  Mark Dolan

IPC: A61F2/06

CPC classification number: A61F2/90 ,  A61F2250/0068

Abstract: A system for treating a vascular condition includes a catheter and a stent disposed on the catheter. The stent includes tubing having a wall defining a central lumen and a plurality of holes. The system further includes a therapeutic agent disposed within the central lumen of the tubing. A method of manufacturing a therapeutic agent carrying stent includes inserting a therapeutic agent within a therapeutic agent delivery system into the central lumen of a hollow metal tube and forming a stent framework from the hollow tube.

Abstract translation: 用于治疗血管状态的系统包括导管和设置在导管上的支架。 支架包括具有限定中心腔和多个孔的壁的管。 该系统还包括设置在管的中心腔内的治疗剂。 制造治疗剂携带支架的方法包括将治疗剂递送系统内的治疗剂插入中空金属管的中心腔，并从中空管形成支架框架。

公开(公告)号：US20080183281A1

公开(公告)日：2008-07-31

申请号：US11668907

申请日：2007-01-30

Applicant: Susan Rea ,  Jeff Allen

Inventor： Susan Rea ,  Jeff Allen

IPC: A61F2/82

CPC classification number: A61L31/146 ,  A61F2/91 ,  A61F2250/0068 ,  A61L31/16 ,  A61L2300/61 ,  A61L2400/18 ,  Y10S623/901

Abstract: A method of manufacturing a drug loaded stent includes applying a photo resistant coating to at least a portion of a stent framework and removing at least a portion of the photo resistant coating from the stent framework. The method further includes applying an etchant to at least a portion of the stent framework and forming a plurality undercut drug reservoirs in the stent framework based on applying the etchant. A stent for treating a vascular condition includes a stent framework, a plurality of undercut reservoirs formed within the stent framework and a therapeutic agent disposed within at least a portion of the plurality of undercut reservoirs.

Abstract translation: 制造载药支架的方法包括将抗光涂层施加到支架框架的至少一部分并从支架框架移除至少一部分耐光涂层。 该方法还包括将蚀刻剂应用于支架框架的至少一部分并且基于施加蚀刻剂在支架框架中形成多个底切药物储存器。 用于治疗血管状态的支架包括支架框架，在支架框架内形成的多个底切储液器和设置在所述多个底切储库的至少一部分内的治疗剂。

公开(公告)号：US20110270340A1

公开(公告)日：2011-11-03

申请号：US12771037

申请日：2010-04-30

Applicant: Gianfranco Pellegrini ,  Susan Rea Peterson ,  Travis Rowe ,  Arvind Srinivas ,  Scott Doig ,  Barry Wohl

Inventor： Gianfranco Pellegrini ,  Susan Rea Peterson ,  Travis Rowe ,  Arvind Srinivas ,  Scott Doig ,  Barry Wohl

IPC: A61N1/05

CPC classification number: A61N1/3756 ,  A61N1/0573 ,  A61N1/37205 ,  A61N1/37518

Abstract: Systems and methods of delivering and retaining a leadless medical implant to tissue, wherein a docking base and the implant are sequentially delivered to an implantation site. In a first stage, the docking base is delivered and deployed into tissue at an implantation site. In a second stage, the implant is navigated through the vasculature and coupled to the docking base. Various mechanisms for navigating the implant to the previously implanted docking base and coupling the implant thereto are described. Navigational mechanisms include advancing the implant over a proximally extending wire portion that is releasably attached to the previously implanted docking base, utilizing fluoroscopic visualization to guide the implant to a previously implanted docking base that is at least partially radiopaque and utilizing electromagnetism to guide the implant to a previously implanted docking base that is electro-magnetizable.

Abstract translation: 将无引导医用植入物递送和保持到组织的系统和方法，其中对接基座和植入物被顺序地递送到植入部位。 在第一阶段，对接基座在植入部位被传送并部署到组织中。 在第二阶段，植入物通过脉管系统导航并且连接到对接基座。 描述了用于将植入物导航到先前植入的对接底座并将植入物联接到其上的各种机构。 导航机构包括将植入物推进在可释放地附接到先前植入的对接基座的近端延伸的线部分上，利用荧光透视可视化将植入物引导至至少部分不透射线的先前植入的对接基座，并利用电磁力将植入物导向 先前植入的可电磁化的对接基座。

公开(公告)号：US20110270339A1

公开(公告)日：2011-11-03

申请号：US12771029

申请日：2010-04-30

Applicant: Robert Murray, III ,  Gianfranco Pellegrini ,  Susan Rea Peterson ,  Travis Rowe ,  Erik Griswold ,  Scott Doig ,  John Kantor

Inventor： Robert Murray, III ,  Gianfranco Pellegrini ,  Susan Rea Peterson ,  Travis Rowe ,  Erik Griswold ,  Scott Doig ,  John Kantor

IPC: A61N1/05

CPC classification number: A61N1/375 ,  A61N1/0573 ,  A61N1/37205 ,  A61N1/37518 ,  A61N1/3756 ,  A61N2001/058

Abstract: Systems and methods of delivering and retaining a leadless medical implant to tissue, wherein a docking base and the implant are sequentially delivered to an implantation site. In a first stage, the docking base is delivered and deployed into tissue at an implantation site. In a second stage, the implant is navigated through the vasculature and coupled to the docking base. Various mechanisms for navigating the implant to the previously implanted docking base and coupling the implant thereto are described. Navigational mechanisms include advancing the implant over a proximally extending wire portion that is releasably attached to the previously implanted docking base, utilizing fluoroscopic visualization to guide the implant to a previously implanted docking base that is at least partially radiopaque and utilizing electromagnetism to guide the implant to a previously implanted docking base that is electro-magnetizable.

公开(公告)号：US20100131001A1

公开(公告)日：2010-05-27

申请号：US12276589

申请日：2008-11-24

Applicant: Susan Rea Peterson

Inventor： Susan Rea Peterson

IPC: A61M29/00 ,  A61B19/00

CPC classification number: A61F2/07 ,  A61F2/90 ,  A61F2002/065 ,  A61F2002/075 ,  A61F2002/077 ,  A61M25/007 ,  A61M25/0084 ,  A61M2025/0681

Abstract: Disclosed herein are systems and methods related to aneurysm treatment. More specifically, the systems and methods disclosed herein relate to localized treatment of aneurysms utilizing polymeric micelles that release therapeutic agent(s) when exposed to energy.

Abstract translation: 本文公开了与动脉瘤治疗相关的系统和方法。 更具体地，本文公开的系统和方法涉及使用在暴露于能量时释放治疗剂的聚合物胶束局部治疗动脉瘤。

公开(公告)号：US07749262B2

公开(公告)日：2010-07-06

申请号：US11252450

申请日：2005-10-17

Applicant: Feridun Ozdil ,  Junghwa Jenn Cho ,  Joseph Berglund ,  Susan Rea

Inventor： Feridun Ozdil ,  Junghwa Jenn Cho ,  Joseph Berglund ,  Susan Rea

IPC: A61F2/06

CPC classification number: A61F2/92 ,  A61F2/91 ,  A61F2/958 ,  A61F2220/0008 ,  A61F2230/0054

Abstract: An intraluminal stent, an intraluminal stent delivery system, and a method of treating a vascular condition. The stent includes a framework with a plurality of flap portions projecting substantially beyond a central core region. The flap portions are movable from a compressed position and an extended position when the stent is deployed. The system includes a catheter and the intraluminal stent. The method includes positioning an intraluminal stent within a vessel. A plurality of flap portions of the stent is extended from a compressed position into contact with the vessel.

Abstract translation: 管腔内支架，腔内支架输送系统和治疗血管病变的方法。 支架包括具有大致突出超过中心芯区域的多个翼片部分的框架。 当支架展开时，翼片部分可从压缩位置和伸出位置移动。 该系统包括导管和管腔内支架。 该方法包括将管腔内支架定位在血管内。 支架的多个翼片部分从压缩位置延伸以与血管接触。

公开(公告)号：US20100131051A1

公开(公告)日：2010-05-27

申请号：US12276583

申请日：2008-11-24

Applicant: Susan Rea Peterson

Inventor： Susan Rea Peterson

IPC: A61F2/06 ,  A61B19/00 ,  A61M29/00

CPC classification number: A61M25/0026 ,  A61B17/12022 ,  A61B17/12118 ,  A61B17/12186 ,  A61F2/07 ,  A61F2/90 ,  A61F2002/065 ,  A61F2002/075 ,  A61F2002/077 ,  A61K33/30 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/434 ,  A61M25/007 ,  A61M2025/0681

Abstract: Disclosed herein are methods and stent graft configurations related to the treatment of aneurysms through the local administration of zinc chelator(s). The zinc chelator(s) can be locally administered by placing one or more of them directly onto a stent graft, incorporating them into a coating found on a stent graft, including them in a delivery device that is associated with a stent graft, and/or injecting them through delivery and/or injection catheters at or near the time of stent graft deployment.

Abstract translation: 本文公开了通过局部施用锌螯合剂治疗动脉瘤的方法和支架移植物构型。 锌螯合剂可以通过将它们中的一种或多种直接放置在支架移植物上而局部施用，将它们并入到覆膜移植物上发现的包衣中，包括它们在与支架移植物相关联的递送装置中，和/ 或在支架移植部署时或附近通过输送和/或注射导管注射它们。

公开(公告)号：US07682388B2

公开(公告)日：2010-03-23

申请号：US11668991

申请日：2007-01-30

Applicant: Susan Rea

Inventor： Susan Rea

IPC: A61F2/06

CPC classification number: A61F2/91 ,  A61F2/958 ,  A61F2250/0068 ,  Y10S623/903

Abstract: A method of treating a vascular condition includes delivering a stent including at least one elongated axial slot to a target region of a vessel and receiving endothelial cell growth in the slots. A system for treating a vascular condition includes a catheter and a stent disposed on the catheter. The stent includes a stent framework including elongated axial slot formed therein and at least one therapeutic agent carried within the elongated axial slots. An outermost surface of the therapeutic agent is recessed within the elongated axial slots from the outer surface of the stent framework to allow endothelial cell growth within the elongated axial slots upon delivery of the stent to a target region of a vessel.

Abstract translation: 治疗血管病症的方法包括将包括至少一个细长轴向狭缝的支架递送到血管的靶区域并在狭槽中接收内皮细胞生长。 用于治疗血管病症的系统包括导管和设置在导管上的支架。 支架包括支架框架，其包括形成在其中的细长轴向槽和在细长轴向槽内承载的至少一个治疗剂。 治疗剂的最外表面从支架框架的外表面凹入细长的轴向狭槽内，以便在将支架输送到血管的靶区域时允许内细胞在细长的轴向狭槽内生长。

公开(公告)号：US20100016950A1

公开(公告)日：2010-01-21

申请号：US12569604

申请日：2009-09-29

Applicant: JOSEPH BERGLUND ,  SUSAN REA

Inventor： JOSEPH BERGLUND ,  SUSAN REA

IPC: A61F2/06

CPC classification number: A61F2/90 ,  A61F2/88 ,  A61F2002/068 ,  A61F2250/0013

Abstract: A stent for implantation within the body of a patient is disclosed. The stent can be formed from one or more stent modules comprising a plurality of stent struts, one or more of which have an inner contour designed for streamlined fluid flow when the stent is implanted within an anatomical passageway of the patient.

Abstract translation: 公开了一种用于植入患者体内的支架。 支架可以由包括多个支架支架的一个或多个支架模块形成，其中一个或多个支架支架具有设计用于当支架植入患者的解剖通道内时流线型流体流动的内部轮廓。