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公开(公告)号:US20250083377A1
公开(公告)日:2025-03-13
申请号:US18883577
申请日:2024-09-12
Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
Inventor: Rafiq Ahmad , Roberto Monroy , David Moises Baca Lopez , Miguel Eduardo Castillo Asuaje , Tanay Kuclourya
IPC: B29C64/118 , B29C64/209 , B29C64/336 , B29C64/393 , B29K105/26 , B33Y10/00 , B33Y30/00 , B33Y50/02
Abstract: Embodiments herein generally relate to the use of a hybrid system, which employs a combination of fused filament deposition (FFD) and direct fused deposition (DFD) modelling systems. The hybrid system can be used with both virgin as well as recycled plastics, and is suitable for multicomponent as well as multi-material printing of a broad range of thermoplastic materials. Owing to the capability of the system to re-use a variety of different plastics for the purpose of plastic printing, the system promotes the “Circular Economy” strategy for part production whereby material after life-use can be easily reincorporated into the supply chain to avoid plastic accumulation.
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公开(公告)号:US20250067076A1
公开(公告)日:2025-02-27
申请号:US18799207
申请日:2024-08-09
Applicant: The Governors of the University of Alberta
Inventor: Rafiq Ahmad , Shahin Zareie , Emanuel Martinez Villanueva
Abstract: A structural control system for civil infrastructures with recovery-based performance under extreme environmental loading is provided. The recovery-based structural control system may be utilized in both newly constructed and existing buildings as a retrofit to reduce the vulnerability to extreme environmental loading. The structural control system combines steel plate shear wall (SPSW) and the shape memory alloy (SMA) to provide extra recovery ability in a building's main element or supplemental structural control systems. The combination of SMA with SPSW, as a lateral resistive force system, develops a self-centering, energy absorber that provides a re-useable and affordable steel plate shear wall, called Smart Self-Centered Shear Wall (SSCSW) system. In the SSCSW system, pre-straining is applied to SMAs to eliminate the residual deformation that is known to appear in long-term use.
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公开(公告)号:US20250025655A1
公开(公告)日:2025-01-23
申请号:US18905533
申请日:2024-10-03
Applicant: The Governors of the University of Alberta
Inventor: Andrew MARTIN , Cole CHRISTIANSON , Ira KATZ
Abstract: A nasal interface apparatus is provided for delivering a gas to a human via a gas supply tube and a pair of tubular nasal inserts. The apparatus includes a manifold hollow body defining an internal chamber, an inlet for fluid communication from the gas supply tube into the internal chamber, an outlet for fluid communication between the internal chamber and the pair of nasal inserts, and an air entrainment port for fluid communication between the internal chamber and a space external to the hollow body. The apparatus also includes a valve member movable relative to the hollow body for varying the size of the open area of the air entrainment port. The open area of the air entrainment port may be varied to regulate a pressure signal detected by a pulse-flow oxygen concentrator (POC).
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公开(公告)号:US12202859B2
公开(公告)日:2025-01-21
申请号:US17509808
申请日:2021-10-25
Applicant: The Governors of the University of Alberta
Inventor: Michael Houghton , Darren Hockman , John L. Law , Chao Chen , Michael Logan
IPC: C07K14/005 , A61K39/00 , A61K39/12 , A61K39/29 , A61P31/14 , C07K1/22 , C07K19/00 , C12N7/00 , C12N15/62 , C12P21/02
Abstract: The present disclosure provides affinity tagged heterodimeric polypeptides comprising a hepatitis C virus (HCV) E1 polypeptide and an HCV E2 polypeptide, where one or both of the E1 and E2 polypeptides comprises an affinity tag. The present disclosure provides a method of producing an affinity tagged E1/E2 heterodimer of the present disclosure. The present disclosure provides methods of producing untagged HCV E1/E2 heterodimers. The present disclosure provides HCV E1/E2 heterodimers, compositions comprising same, and methods of inducing an immune response to HCV.
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公开(公告)号:US12186309B2
公开(公告)日:2025-01-07
申请号:US17950785
申请日:2022-09-22
Applicant: The Governors of the University of Alberta
Inventor: James A. Nieman , M. Joanne Lemieux , D. Lorne Tyrrell , Mostofa Hena , Appan Srinivas Kandadai , Alexandr Belovodskiy , Michael A. Joyce , Elena Arutyunova
IPC: A61K31/454 , A61P31/14
Abstract: The present disclosure provides compounds and methods for inhibiting a virus infection, such as a Baltimore Group IV RNA virus infection. Aspects of the present disclosure also include methods of treating a Baltimore Group IV RNA virus infection in a subject. The present disclosure also provides pharmaceutical compositions related to the same.
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公开(公告)号:US12174218B2
公开(公告)日:2024-12-24
申请号:US17638937
申请日:2020-08-31
Inventor: Robert A. Wolkow , Jason Pitters , Mark Salomons
Abstract: A nano-positioning system for fine and coarse nano-positioning including at least one actuator, wherein the at least one actuator includes a high Curie temperature material and wherein the nano-positioning system is configured to apply a voltage to the at least one actuator to generate fine and/or coarse motion by the at least one actuator. The nano-positioning system being a stand-alone system, a scanning probe microscope, or an attachment to an existing microscope configured to perform a method of creepless nano-positioning that includes positioning a probe relative to a first area of a substrate using coarse stepping and interacting with the first area of the substrate using fine motion after less than 60 seconds of the positioning the probe. The movement of the scanning probe microscope is actuated by a high Curie temperature piezoelectric material that limits and/or eliminates creep, hysteresis and aging.
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公开(公告)号:US20240389614A1
公开(公告)日:2024-11-28
申请号:US18693449
申请日:2022-09-29
Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
Inventor: Lingyun CHEN
Abstract: Disclosed are thermo-reversible protein gels formed from (i) pulse plant proteins extracted by a salted in-salted out precipitation method, (ii) vicilin and/or convicilin, or (iii) a pulse plant protein isolate having an isoelectric point of greater than 5.0; methods of forming such gels, and food or beverages including such gels.
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公开(公告)号:US20240294405A1
公开(公告)日:2024-09-05
申请号:US18440027
申请日:2024-02-13
Applicant: The Governors of the University of Alberta
Inventor: Xuehua Zhang , Yawen Gao
IPC: C02F1/46 , A01G9/24 , B01F25/312 , B01F101/00 , C02F1/30
CPC classification number: C02F1/4608 , B01F25/31242 , C02F1/30 , A01G9/243 , B01F2101/305 , B01F2215/0431 , B01F2215/045
Abstract: A high efficiency plasma activation system for large scale treatment of liquid including a liquid tank; a pump having an inlet fluidly connected to an outlet of the liquid tank; a self-suction mechanism having a liquid inlet fluidly connected to an outlet of the pump, an air inlet, and an outlet fluidly connected to an inlet of the liquid tank; and a plasma generator having a plasma discharge nozzle positioned adjacent to the air inlet of the self-suction mechanism and configured to discharge gas phase plasma into the air inlet of the self-suction mechanism and introduce micro/nano bubbles (MNBs) into a flow of liquid to be treated to where the MNBs collapse to agitate and impregnate the liquid with a gas, for highly efficient plasma activation of liquid on a large scale as a green and sustainable technology for disinfection in the food industry and agriculture.
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9.
公开(公告)号:US20240238442A1
公开(公告)日:2024-07-18
申请号:US18558999
申请日:2021-05-05
Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
Inventor: Matthew MACAULEY , Abhishek BATTACHERJEE , Arjun Singh BAINS , Gour DASKHAN
CPC classification number: A61K47/6911 , A61K9/0085 , A61K47/61
Abstract: The present application provides a liposomal composition that multivalently displays a specific glycan ligand, or combination of specific glycan ligands, to specifically target CD33 on microglial cells. Multivalent engagement of CD33 with glycan ligands in the liposomal composition are useful in modulating microglial cell function, particularly as a therapeutic for the preventing, treating or delaying progression of Alzheimer's disease.
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公开(公告)号:US20240148767A1
公开(公告)日:2024-05-09
申请号:US18279517
申请日:2022-03-03
Applicant: The Governors of the University of Alberta
Inventor: Jason DYCK , Karen Lynn MADSEN
IPC: A61K31/7048 , A61P1/04
CPC classification number: A61K31/7048 , A61P1/04
Abstract: A use of empagliflozin for the treatment of ulcerative colitis and Crohn's disease.
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