公开(公告)号：US20250152291A1

公开(公告)日：2025-05-15

申请号：US18941218

申请日：2024-11-08

Applicant: The Trustees of Indiana University

Inventor： Jignesh Tailor ,  Steven Wakeman

IPC: A61B90/00 ,  A45D24/02 ,  A61B17/17

Abstract: A hair preservation surgical device configured to form and at least partially maintain a part or separation among a plurality of hair strands of a patient. A plurality of hair engagement bodies of the device can engage and pull a portion of the plurality of hair strands via displacement of the surgical device, including displacement resulting from deformation of the device, to at least assist in retaining the engaged hair strands away from the part. The surgical device can further be displaced such that an access aperture of the device is positioned over the part. The access aperture can extend through the surgical device and provide a location for performances of surgical procedures at, and through, the location of the part. Attachment mechanisms can be used to engage one or more anchors of the device to selectively secure the device to the patient, including to the scalp of the patient.

公开(公告)号：US20250034523A1

公开(公告)日：2025-01-30

申请号：US18716889

申请日：2022-12-09

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： Eri HASHINO ,  Stephen T. MOORE

IPC: C12N5/0793

Abstract: Provided herein are methods for generation of human cochlear hair cells from pluripotent stem cells. More specifically, provided herein are methods for generating three-dimensional cell organoids comprising inner ear hair cells, sensory neurons and supporting cells from human pluripotent stem cells.

公开(公告)号：US20250021908A1

公开(公告)日：2025-01-16

申请号：US18769158

申请日：2024-07-10

Applicant: The Trustees of Indiana University

Inventor： Fawzi Ben Messaoud

IPC: G06Q10/0637 ,  G06Q50/20

Abstract: Computer-implemented AI assistants, computer-implemented educational platforms, and methods of hierarchically processing data. Such an AI assistant includes an extraction module, a transform module, an integration module, and a manager module. The extraction module includes an AI data extraction agent that identifies and extracts relevant raw digital data from digital data sources. The transform module includes an AI data transformation agent that transforms the raw digital data into a usable form within the computer-implemented educational platform. The integration module includes an AI data integration agent that integrates the transformed data into a digital knowledge base. The manager module includes an AI agent that coordinates workflow of and dataflow between the extraction module, the transform module, and the integration module. The AI assistant may have a hierarchical structure that automates data processing from extraction to transformation to integration. The AI assistant can be implemented as part of a computer-implemented educational platform.

公开(公告)号：US20250006483A1

公开(公告)日：2025-01-02

申请号：US18576405

申请日：2022-07-07

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： Martin F. JARROLD ,  Daniel BOTAMANENKO

IPC: H01J49/42

Abstract: A method for optimizing an electrostatic linear ion trap (ELIT) for mass-to-charge (m/z) measurement resolution may include determining initial electrostatic and geometric parameters of the ELIT, modifying at least one of the initial electrostatic parameters to produce a resulting set of modified electrostatic parameters with which m/z measurements made by the ELIT are independent of a trajectory of ions moving within the ELIT relative to a longitudinal axis of the ELIT, modifying at least one of the initial geometric parameters to produce a resulting set of modified geometric parameters with which m/z measurements made by the ELIT are independent of energy of ions moving within the ELIT, and constructing the ELIT using the modified sets of electrostatic and geometric parameters.

公开(公告)号：US20240412967A1

公开(公告)日：2024-12-12

申请号：US18808351

申请日：2024-08-19

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： Martin F. JARROLD ,  Aaron A. TODD

IPC: H01J49/42 ,  H01J49/40

Abstract: A charge detection mass spectrometer includes an ion trap configured to store ions therein and to release stored ions therefrom, and an electrostatic linear ion trap (ELIT) array, in the form of at least two ELITs or ELIT regions each spaced apart from the ion trap, each ELIT or ELIT region including first and second ion mirrors and a charge detection cylinder positioned therebetween. The ion trap is controlled to release at least some of the stored ions to travel toward and into each of the ELITs or ELIT regions, and the first and second ion mirrors of each of the ELITs or ELIT regions is controlled in a manner which traps one or more ions traveling therein and causes the trapped ion(s) to oscillate back and forth between the first and second ion mirrors each time passing through and inducing a corresponding charge on the charge detection cylinder.

公开(公告)号：US20240410903A1

公开(公告)日：2024-12-12

申请号：US18698129

申请日：2022-10-13

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY ,  PURDUE RESEARCH FOUNDATION ,  SAPIENZA UNIVERSITÀ DI ROMA

Inventor： Roman M. NATOLI ,  Sarah MALEK ,  Federico MARINI

IPC: G01N33/68

Abstract: Methods of detecting diagnostic indicators of a fracture-related infection (FRI) in a patient's biological sample are provided along with methods of treating the identified patients having an FRI.

公开(公告)号：US20240395913A1

公开(公告)日：2024-11-28

申请号：US18663795

申请日：2024-05-14

Applicant: The Trustees of Indiana University

Inventor： Haitham Kanakri ,  Maher Rizkalla ,  Euzeli Cipriano Dos Santos, JR.

IPC: H01L29/739 ,  H01L23/495 ,  H01L29/16 ,  H01L29/66

Abstract: Composite substrates for use in semiconductor switching devices, including insulated gate bipolar transistors (IGBT), switching devices formed therewith, and methods of use. The composite substrate includes a nano-scale graphene film on a sapphire-containing surface of a dielectric substrate, wherein the nano-scale graphene film and sapphire-containing surface exhibit lattice alignment properties capable of improving thermal performance of the switching device and reducing local temperature hotspots in the switching device.

公开(公告)号：US20240391966A1

公开(公告)日：2024-11-28

申请号：US18802840

申请日：2024-08-13

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： Ronald Mark Payne

IPC: C07K14/47 ,  A61K9/00 ,  A61K38/00 ,  A61K38/17 ,  A61P9/02 ,  A61P25/28

Abstract: A TAT-FXN fusion polypeptide useful in treating subjects diagnosed with Friedrich's Ataxia, hypertrophic cardiomyopathy, or both are disclosed, as are related methods of treatment and pharmaceutical compositions.

公开(公告)号：US20240358485A1

公开(公告)日：2024-10-31

申请号：US18649689

申请日：2024-04-29

Applicant: The Trustees of Indiana University

Inventor： Brian D. Overshiner ,  William Roy Thompson ,  Parker Evans ,  Perla Reyes Fernandez ,  Daniel Georgiev Simeonov

IPC: A61D7/00 ,  A61M15/00

CPC classification number: A61D7/00 ,  A61M15/0066 ,  A61M2205/3306 ,  A61M2205/581 ,  A61M2205/8206

Abstract: Animal drug delivery systems and methods. Such a system includes a carrier cartridge to carry and dispense a plurality of drug doses, a monitoring device, and a controller operatively coupled with the carrier cartridge and the monitoring device. The controller operates the carrier cartridge to dispense at least one of the drug doses to an animal subject at each of a plurality of preselected dispensing intervals. The controller is also configured to operate the monitoring device to record the animal subject ingesting the dispensed drug doses. The system may be configured to provide drug pellets to mice based on researcher needs, allow for mouse monitoring to confirm drug delivery, enable behavioral studies to be conducted using operant condition, and/or to fit into a specific lab research animal cage.

公开(公告)号：US12102734B2

公开(公告)日：2024-10-01

申请号：US17239322

申请日：2021-04-23

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： Alexander Gumennik ,  Louis Alexandre van der Elst ,  Merve Gokce Kurtoglu

IPC: A61L27/00 ,  A61L27/04 ,  A61L27/36 ,  A61L27/38 ,  A61L27/50 ,  B33Y80/00 ,  A61L27/14

CPC classification number: A61L27/3839 ,  A61L27/04 ,  A61L27/3633 ,  A61L27/50 ,  B33Y80/00 ,  A61L27/14 ,  A61L2300/414 ,  A61L2420/04 ,  A61L2420/08

Abstract: A method of producing bioengineered tissue includes coating a microstructured fiber with a bioink containing a plurality of living cells. The microstructured fiber is embedded with microfluidic channels defining periodic outlet apertures, a plurality of ultrasonic transducers, at least one chemical sensor, and at least one temperature sensor. The method further includes applying the coated fiber to an anatomic model of an organ. The microfluidic channels and outlet apertures of the fiber are configured to function as an artificial blood-vessel system to the bioengineered tissue, thereby supplying building material for the proliferation of the plurality of living cells, and allowing the bioengineered tissue to mature into functional tissue.