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    Thiazole Derivatives Having Vap-1 Inhibitory Activity
    1.
    发明申请
    Thiazole Derivatives Having Vap-1 Inhibitory Activity 审中-公开
    具有Vap-1抑制活性的噻唑衍生物

    公开(公告)号：US20080015202A1

    公开(公告)日：2008-01-17

    申请号：US11574946

    申请日：2005-09-08

    Applicant: Takayuki Inoue ,  Takashi Tojo ,  Masataka Morita

    Inventor： Takayuki Inoue ,  Takashi Tojo ,  Masataka Morita

    IPC: A61K31/426 ,  A61K31/445 ,  A61K31/497 ,  A61P27/02 ,  C07D411/00

    CPC classification number: C07D417/10 ,  C07D277/46 ,  C07D417/06 ,  C07D417/12

    Abstract: A compound of the formula (I): U-V-W-X-Y-Z  (I) wherein U is lower alkyl; V is —CONH— or —NR1CO— wherein R1 is a hydrogen or lower alkyl; W is a bond or lower alkylene; X is a bivalent residue derived from optionally substituted thiazole; Y is a bond or lower alkylene; and Z is a group of the formula: wherein R2 is a group of the formula: -A-B-D-E-F-G wherein A is a bond or lower alkylene; B is a bond, —NH— or D is a bond, —CS— or —CO—; E is a bond or —NH—; F is a bond, —CO—, —O— or —SO2—; and G is lower alkyl, optionally protected amino, —OH, phenyl, R3 is lower alkyl, provided that when Z is a group of the formula: then G should not be amino, when Z is a group of the formula: then G should not be when Z is a group of the formula: and G is optionally protected amino, then D should be —CS—, or then A should be lower alkylene, B or E should be —NH— and F should be —CO—; or a pharmaceutically acceptable salt thereof useful as a vascular adhesion protein-1 (VAP-1) inhibitor as well as a pharmaceutical composition and a method for preventing or treating a VAP-1 associated disease, especially macular edema, which method includes administering an effective amount of the compound or a pharmaceutically acceptable salt thereof to a subject, and the like.

    Abstract translation: 式（I）的化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？> UVWXYZ（I）<？in-line-formula description =“In-line Formulas” end =“tail”？>其中U是低级烷基; V是-CONH-或-NR 1 CO-，其中R 1是氢或低级烷基; W是键或低级亚烷基; X是衍生自任选取代的噻唑的二价残基; Y是键或低级亚烷基; 并且Z是下式的基团：其中R 2是下列基团：-A-B-D-E-F-G其中A是键或低级亚烷基; B是键，-NH-或D是键，-CS-或-CO-; E是键或-NH-; F是键，-CO - ， - O-或-SO 2 - 。 并且G为低级烷基，任意保护的氨基，-OH，苯基，R 3为低级烷基，条件是当Z为下式基团时，则G不应为氨基，当Z为 组式为：那么G不应该是当Z是下式的基团时：G是任意保护的氨基，那么D应该是-CS-，或者A应该是低级亚烷基，B或E应该是-NH- 而F应为-CO-; 或其药学上可接受的盐可用作血管粘附蛋白-1（VAP-1）抑制剂，以及用于预防或治疗VAP-1相关疾病，特别是黄斑水肿的药物组合物和方法，该方法包括施用有效的 化合物或其药学上可接受的盐对受试者的量等。

    Thiazole Derivatives Having Vap-1 Inhibitory Activity
    5.
    发明申请
    Thiazole Derivatives Having Vap-1 Inhibitory Activity 审中-公开
    具有Vap-1抑制活性的噻唑衍生物

    公开(公告)号：US20070254931A1

    公开(公告)日：2007-11-01

    申请号：US11572772

    申请日：2005-07-27

    Applicant: Takayuki Inoue ,  Takashi Tojo ,  Masataka Morita

    Inventor： Takayuki Inoue ,  Takashi Tojo ,  Masataka Morita

    IPC: A61K31/426 ,  A61P19/02 ,  A61P19/08 ,  A61P3/10 ,  A61P9/10 ,  C07D277/46

    CPC classification number: C07D277/46

    Abstract: A compound of the formula (I), (II), (III) or (IV): wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof useful as a vascular adhesion protein-1 (VAP-1) inhibitor, a pharmaceutical composition, a method for preventing or treating a VAP-1 associated disease, especially macular edema, which method includes administering an effective amount of the compound or a pharmaceutically acceptable salt thereof to a subject, and the like.

    Abstract translation: 式（I），（II），（III）或（IV）的化合物：其中每个符号如说明书中所定义，或其药学上可接受的盐可用作血管粘附蛋白-1（VAP-1） 抑制剂，药物组合物，预防或治疗VAP-1相关疾病，特别是黄斑水肿的方法，该方法包括向受试者施用有效量的化合物或其药学上可接受的盐等。

    Apparatus and method for creating graphics
    9.
    发明授权
    Apparatus and method for creating graphics 失效
    用于创建图形的装置和方法

    公开(公告)号：US06507345B1

    公开(公告)日：2003-01-14

    申请号：US08829424

    申请日：1997-03-31

    Applicant: Takashi Tojo

    Inventor： Takashi Tojo

    IPC: G09G500

    CPC classification number: G06F3/04812

    Abstract: An apparatus and method for creating graphics in which an image pattern to be pasted is displayed on the screen of a display unit through a display content VRAM, by inputting an operation command from an operator for pasting the image pattern on the display screen of a display unit from an input unit, referring to pattern data to be pasted and also referring to animation information data, obtaining information on how the form and color temporarily change when the pattern is pasted, creating the display data, and displaying the display data on the screen of the display unit.

    Abstract translation: 一种用于创建图形的装置和方法，其中通过显示内容VRAM在显示单元的屏幕上显示要粘贴的图像图案的图形，通过从操作者输入用于将图像图案粘贴在显示器的显示屏幕上的操作命令 单元，参考要粘贴的图案数据，并且还参考动画信息数据，获取当图案被粘贴时形式和颜色如何暂时改变的信息，创建显示数据，以及在屏幕上显示显示数据 的显示单元。

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