公开(公告)号：US07016713B2

公开(公告)日：2006-03-21

申请号：US10753506

申请日：2004-01-08

Applicant: Craig M. Gardner ,  Trent D. Ridder ,  William Gruner

Inventor： Craig M. Gardner ,  Trent D. Ridder ,  William Gruner

IPC: A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/1491 ,  A61B2560/0233 ,  A61B2562/146

Abstract: The present invention relates generally to a non-invasive method and apparatus for measuring a fluid analyte, particularly relating to glucose or alcohol contained in blood or tissue, utilizing spectroscopic methods. More particularly, the method and apparatus incorporate means for detecting and quantifying changes in the concentration of specific analytes in tissue fluid. Also, the method and apparatus can be used to predict future levels of analyte concentration either in the tissue fluid or in blood in an adjacent vascular system.

Abstract translation: 本发明一般涉及一种用于测量流体分析物，特别是与血液或组织中所含的葡萄糖或醇相关的非侵入性方法和装置，其使用光谱方法。 更具体地，该方法和装置包括用于检测和量化组织液中特定分析物浓度变化的装置。 此外，该方法和装置可以用于预测在相邻血管系统中的组织液或血液中的分析物浓度的未来水平。

公开(公告)号：US20130317328A1

公开(公告)日：2013-11-28

申请号：US13944389

申请日：2013-07-17

Applicant: Trent D. Ridder ,  Rob Johnson ,  Russell Abbink ,  John D. Maynard

Inventor： Trent D. Ridder ,  Rob Johnson ,  Russell Abbink ,  John D. Maynard

IPC: A61B5/145 ,  A61B5/1495 ,  A61B5/1455

CPC classification number: A61B5/14546 ,  A61B5/0075 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/6824 ,  A61B5/6835 ,  A61B2562/0233

Abstract: Methods and apparatuses for the determination of an attribute of the tissue of an individual use non-invasive Raman spectroscopy. For example, the alcohol concentration in the blood or tissue of an individual can be determined. A portion of the tissue is illuminated with light, which propagates into the tissue where it is Raman scattered. The Raman scattered light is detected and can be combined with a model relating Raman spectra to alcohol concentration to determine the alcohol concentration in the blood or tissue. Correction techniques can reduce determination errors due to detection of light other than that from Raman scattering from the alcohol in the tissue. Other biologic information can be used with the Raman spectral properties to aid in the determination of alcohol concentration, for example age, height, weight, medical history and his/her family, ethnicity, skin melanin content, or a combination thereof. The method and apparatus can be optimized to provide reproducible and uniform radiance of the tissue, low tissue sampling error, depth targeting of the tissue layers or sample locations that contain the attribute of interest, efficient collection of Raman spectra, optical throughput, photometric accuracy, large dynamic range, thermal stability, calibration maintenance, calibration transfer, built-in quality control, and ease-of-use.

Abstract translation: 用于确定个体使用非侵入性拉曼光谱的组织属性的方法和装置。 例如，可以确定个体的血液或组织中的酒精浓度。 组织的一部分用光照射，其传播到其中拉曼散射的组织中。 检测拉曼散射光，并将其与拉曼光谱相关的模型与酒精浓度组合，以确定血液或组织中的酒精浓度。 校正技术可以减少除了来自组织中的醇的拉曼散射以外的光的检测的测定误差。 其他生物学信息可以与拉曼光谱性质一起使用以帮助测定酒精浓度，例如年龄，身高，体重，病历和他/她的家庭，种族，皮肤黑色素含量或其组合。 该方法和装置可以被优化以提供组织的可重现和均匀的辐射，低组织采样误差，组织层的深度瞄准或包含感兴趣属性的样本位置，有效收集拉曼光谱，光学吞吐量，光度精度， 大动态范围，热稳定性，校准维护，校准传输，内置质量控制和易用性。

公开(公告)号：US08581697B2

公开(公告)日：2013-11-12

申请号：US12107764

申请日：2008-04-23

Applicant: Trent D Ridder ,  Rob Johnson ,  Russell Abbink ,  John D Maynard

Inventor： Trent D Ridder ,  Rob Johnson ,  Russell Abbink ,  John D Maynard

IPC: G05B23/00

CPC classification number: A61B5/0059 ,  A61B5/0075 ,  A61B5/14546 ,  A61B5/1455

Abstract: Methods and apparatuses for the determination of an attribute of the tissue of an individual use non-invasive Raman spectroscopy. For example, the alcohol concentration in the blood or tissue of an individual can be determined non-invasively. A portion of the tissue is illuminated with light, the light propagates into the tissue where it is Raman scattered within the tissue. The Raman scattered light is then detected and can be combined with a model relating Raman spectra to alcohol concentration in order to determine the alcohol concentration in the blood or tissue of the individual. Correction techniques can be used to reduce determination errors due to detection of light other than that from Raman scattering from the alcohol in the tissue. Other biologic information can be used in combination with the Raman spectral properties to aid in the determination of alcohol concentration, for example age of the individual, height of the individual, weight of the individual, medical history of the individual and his/her family, ethnicity, skin melanin content, or a combination thereof. The method and apparatus can be highly optimized to provide reproducible and, preferably, uniform radiance of the tissue, low tissue sampling error, depth targeting of the tissue layers or sample locations that contain the attribute of interest, efficient collection of Raman spectra from the tissue, high optical throughput, high photometric accuracy, large dynamic range, excellent thermal stability, effective calibration maintenance, effective calibration transfer, built-in quality control, and ease-of-use.

Abstract translation: 用于确定个体使用非侵入性拉曼光谱的组织属性的方法和装置。 例如，可以非侵入性地确定个体的血液或组织中的酒精浓度。 组织的一部分用光照射，光传播到组织中，其中拉曼散布在组织内。 然后检测拉曼散射光，并且可以将与拉曼光谱相关的模型与酒精浓度组合以确定个体的血液或组织中的酒精浓度。 校正技术可用于减少除了来自组织中的醇的拉曼散射以外的光的检测的测定误差。 其他生物信息可以与拉曼光谱性质结合使用，以帮助确定酒精浓度，例如个体的年龄，个体的身高，个体的体重，个体及其家人的病史， 种族，皮肤黑色素含量或其组合。 该方法和装置可以被高度优化以提供组织的可再现的，优选地均匀的辐射，低组织取样误差，组织层的深度瞄准或包含感兴趣属性的样本位置，从组织中有效收集拉曼光谱 ，光学吞吐量高，光度精度高，动态范围大，热稳定性好，有效的校准维护，有效的校准传输，内置的质量控制和易于使用。

公开(公告)号：US08515506B2

公开(公告)日：2013-08-20

申请号：US12107765

申请日：2008-04-23

Applicant: Trent D Ridder ,  Rob Johnson ,  Russell Abbink ,  John D Maynard

Inventor： Trent D Ridder ,  Rob Johnson ,  Russell Abbink ,  John D Maynard

IPC: A61B5/1455 ,  G06F7/04 ,  G05B19/00

CPC classification number: A61B5/0075 ,  A61B5/0059 ,  A61B5/14546 ,  A61B5/1455

Abstract: Methods and apparatuses for the determination of an attribute of the tissue of an individual use non-invasive Raman spectroscopy. For example, the alcohol concentration in the blood or tissue of an individual can be determined non-invasively. A portion of the tissue is illuminated with light, the light propagates into the tissue where it is Raman scattered within the tissue. The Raman scattered light is then detected and can be combined with a model relating Raman spectra to alcohol concentration in order to determine the alcohol concentration in the blood or tissue of the individual. Correction techniques can be used to reduce determination errors due to detection of light other than that from Raman scattering from the alcohol in the tissue. Other biologic information can be used in combination with the Raman spectral properties to aid in the determination of alcohol concentration, for example age of the individual, height of the individual, weight of the individual, medical history of the individual and his/her family, ethnicity, skin melanin content, or a combination thereof. The method and apparatus can be highly optimized to provide reproducible and, preferably, uniform radiance of the tissue, low tissue sampling error, depth targeting of the tissue layers or sample locations that contain the attribute of interest, efficient collection of Raman spectra from the tissue, high optical throughput, high photometric accuracy, large dynamic range, excellent thermal stability, effective calibration maintenance, effective calibration transfer, built-in quality control, and ease-of-use.

Abstract translation: 用于确定个体使用非侵入性拉曼光谱的组织属性的方法和装置。 例如，可以非侵入性地确定个体的血液或组织中的酒精浓度。 组织的一部分用光照射，光传播到组织中，其中拉曼散布在组织内。 然后检测拉曼散射光，并且可以将与拉曼光谱相关的模型与酒精浓度组合以确定个体的血液或组织中的酒精浓度。 校正技术可用于减少除了来自组织中的醇的拉曼散射以外的光的检测的测定误差。 其他生物信息可以与拉曼光谱性质结合使用，以帮助确定酒精浓度，例如个体的年龄，个体的身高，个体的体重，个体及其家人的病史， 种族，皮肤黑色素含量或其组合。 该方法和装置可以被高度优化以提供组织的可再现的，优选地均匀的辐射，低组织取样误差，组织层的深度瞄准或包含感兴趣属性的样本位置，从组织中有效收集拉曼光谱 ，光学吞吐量高，光度精度高，动态范围大，热稳定性好，有效的校准维护，有效的校准传输，内置的质量控制和易于使用。

公开(公告)号：US07761126B2

公开(公告)日：2010-07-20

申请号：US11328927

申请日：2006-01-10

Applicant: Craig M. Gardner ,  Trent D. Ridder ,  William Gruner

Inventor： Craig M. Gardner ,  Trent D. Ridder ,  William Gruner

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/1491 ,  A61B2560/0233 ,  A61B2562/146

Abstract: The present invention relates generally to a non-invasive method and apparatus for measuring a fluid analyte, particularly relating to glucose or alcohol contained in blood or tissue, utilizing spectroscopic methods. More particularly, the method and apparatus incorporate means for detecting and quantifying changes in the concentration of specific analytes in tissue fluid. Also, the method and apparatus can be used to predict future levels of analyte concentration either in the tissue fluid or in blood in an adjacent vascular system.

Abstract translation: 本发明一般涉及一种用于测量流体分析物，特别是与血液或组织中所含的葡萄糖或醇相关的非侵入性方法和装置，其使用光谱方法。 更具体地，该方法和装置包括用于检测和量化组织液中特定分析物浓度变化的装置。 此外，该方法和装置可以用于预测在相邻血管系统中的组织液或血液中的分析物浓度的未来水平。

公开(公告)号：US07403804B2

公开(公告)日：2008-07-22

申请号：US10852415

申请日：2004-05-24

Applicant: Trent D. Ridder ,  John D. Maynard ,  Russell E. Abbink ,  Robert D. Johnson ,  Edward L. Hull ,  Andrew D. Meigs ,  Alan Ross ,  Dashiell A. Birnkrant

Inventor： Trent D. Ridder ,  John D. Maynard ,  Russell E. Abbink ,  Robert D. Johnson ,  Edward L. Hull ,  Andrew D. Meigs ,  Alan Ross ,  Dashiell A. Birnkrant

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/0075 ,  A61B5/14546

Abstract: An apparatus and method for non-invasive determination of attributes of human tissue by quantitative infrared spectroscopy. The system includes subsystems optimized to contend with the complexities of the tissue spectrum, high signal-to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, and calibration transfer problems. The subsystems include an illumination subsystem, a tissue sampling subsystem, a spectrometer subsystem, a data acquisition subsystem, and a processing subsystem. The invention is applicable, as examples, to determining the concentration or change of concentration of alcohol in human tissue.

Abstract translation: 一种用于通过定量红外光谱非侵入式确定人体组织属性的装置和方法。 该系统包括优化的子系统，以应对组织光谱的复杂性，高信噪比和光度精度要求，组织采样误差，校准维护问题和校准转移问题。 子系统包括照明子系统，组织采样子系统，光谱仪子系统，数据采集子系统和处理子系统。 作为实例，本发明可用于确定人体组织中酒精浓度或浓度的变化。