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    Portable high gain fluorescence detection system
    1.
    发明授权
    Portable high gain fluorescence detection system 有权
    便携式高增益荧光检测系统

    公开(公告)号：US08431389B2

    公开(公告)日：2013-04-30

    申请号：US13245124

    申请日：2011-09-26

    Applicant: C. Frederick Battrell ,  Troy D. Daiber

    Inventor： C. Frederick Battrell ,  Troy D. Daiber

    IPC: C12M1/34

    CPC classification number: G01N21/6456 ,  B01L7/52 ,  C12M23/16 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6454 ,  G01N2201/0245

    Abstract: An instrument for fluorometric assays in liquid samples is disclosed. The instrument may include multiple optical channels for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. The disclosed instrument finds utility in any number of applications, including microfluidic molecular biological assays based on PCR amplification of target nucleic acids and fluorometric assays in general.

    Abstract translation: 公开了用于液体样品中荧光测定的仪器。 仪器可以包括用于监测与靶分析物相关联的第一荧光团的多个光学通道和与对照相关联的第二荧光团。 所公开的仪器可用于任何数量的应用，包括基于目标核酸的PCR扩增和荧光测定的微流体分子生物学测定。

    PORTABLE HIGH GAIN FLUORESCENCE DETECTION SYSTEM
    2.
    发明申请
    PORTABLE HIGH GAIN FLUORESCENCE DETECTION SYSTEM 有权
    便携式高增益荧光检测系统

    公开(公告)号：US20120135511A1

    公开(公告)日：2012-05-31

    申请号：US13191120

    申请日：2011-07-26

    Applicant: C. Frederick Battrell ,  Troy D. Daiber ,  William Samuel Hunter

    Inventor： C. Frederick Battrell ,  Troy D. Daiber ,  William Samuel Hunter

    IPC: C12M1/40

    CPC classification number: G01N21/6456 ,  B01L7/52 ,  C12M23/16 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6454 ,  G01N2201/0245

    Abstract: Disclosed is a compact, microprocessor-controlled instrument for fluorometric assays in liquid samples, the instrument having a floating stage with docking bay for receiving a microfluidic cartridge and a scanning detector head with on-board embedded microprocessor for controlling source LEDs, emission signal amplification and filtering in an isolated, low noise, high gain environment within the detector head. Multiple optical channels may be incorporated in the scanning head. In a preferred configuration, the assay is validated using dual channel optics for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. Applications include molecular biological assays based on PCR amplification of target nucleic acids and fluorometric assays in general, many of which require temperature control during detection. Sensitivity and resistance to bubble interference during scanning are shown to be improved by use of a heating block with reflective mirror face in intimate contact with a thermo-optical window enclosing the liquid sample.

    Abstract translation: 公开了一种用于液体样品中的荧光测定的紧凑型微处理器控制仪器，该仪器具有用于接收微流控盒的对接舱的浮动台和具有用于控制源LED的放射性嵌入式微处理器的扫描检测器头，发射信号放大和 在检测器头内的隔离，低噪声，高增益环境中进行滤波。 多个光通道可并入扫描头。 在优选的配置中，使用双通道光学器件验证测定，用于监测与靶分析物相关联的第一荧光团和与对照相关联的第二荧光团。 应用包括基于目标核酸的PCR扩增和荧光测定的分子生物测定法，其中许多在检测期间需要温度控制。 通过使用具有与包围液体样品的热光学窗口紧密接触的反射镜面的加热块，可以改善扫描期间对气泡干扰的灵敏度和抗性。

    Portable high gain fluorescence detection system
    6.
    发明授权
    Portable high gain fluorescence detection system 有权
    便携式高增益荧光检测系统

    公开(公告)号：US08329453B2

    公开(公告)日：2012-12-11

    申请号：US13191120

    申请日：2011-07-26

    Applicant: C. Frederick Battrell ,  Troy D. Daiber ,  William Samuel Hunter

    Inventor： C. Frederick Battrell ,  Troy D. Daiber ,  William Samuel Hunter

    IPC: C12M1/34

    CPC classification number: G01N21/6456 ,  B01L7/52 ,  C12M23/16 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6454 ,  G01N2201/0245

    Abstract: Disclosed is a compact, microprocessor-controlled instrument for fluorometric assays in liquid samples, the instrument having a floating stage with docking bay for receiving a microfluidic cartridge and a scanning detector head with on-board embedded microprocessor for controlling source LEDs, emission signal amplification and filtering in an isolated, low noise, high gain environment within the detector head. Multiple optical channels may be incorporated in the scanning head. In a preferred configuration, the assay is validated using dual channel optics for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. Applications include molecular biological assays based on PCR amplification of target nucleic acids and fluorometric assays in general, many of which require temperature control during detection. Sensitivity and resistance to bubble interference during scanning are shown to be improved by use of a heating block with reflective mirror face in intimate contact with a thermo-optical window enclosing the liquid sample.

    Abstract translation: 公开了一种用于液体样品中的荧光测定的紧凑型微处理器控制仪器，该仪器具有带有用于接收微流控盒的对接槽的浮动台和具有用于控制源LED的板上嵌入式微处理器的扫描检测器头，发射信号放大和 在检测器头内的隔离，低噪声，高增益环境中进行滤波。 多个光通道可并入扫描头。 在优选的配置中，使用双通道光学器件验证测定，用于监测与靶分析物相关联的第一荧光团和与对照相关联的第二荧光团。 应用包括基于目标核酸的PCR扩增和荧光测定的分子生物测定法，其中许多在检测期间需要温度控制。 通过使用具有与包围液体样品的热光学窗口紧密接触的反射镜面的加热块，可以改善扫描期间对气泡干扰的灵敏度和抗性。

    System for determining position of normal shock in supersonic flow
    7.
    发明授权
    System for determining position of normal shock in supersonic flow 失效
    用于确定超音速流动中正常休克位置的系统

    公开(公告)号：US5072612A

    公开(公告)日：1991-12-17

    申请号：US564539

    申请日：1990-08-07

    Applicant: Donald G. Iverson, Jr. ,  Troy D. Daiber

    Inventor： Donald G. Iverson, Jr. ,  Troy D. Daiber

    IPC: G01M9/06

    CPC classification number: G01M9/06

    Abstract: Light from a plurality of light emitting diodes is transmitted through optical cables (12) to a lens system. The lenses (56, 58) expand and collimate the light and project it in a sheet (16) across the supersonic inlet of an aircraft power plant perpendicular to incoming airflow. A normal shock bends a portion of the sheet of light (16). A linear array of a multiplicity of optical fiber ends collects discrete samples of light. The samples are processed and compared to a predetermined profile to determine the shock location.

    Abstract translation: 来自多个发光二极管的光通过光缆（12）传输到透镜系统。 透镜（56,58）使光线膨胀并准直，并将其投射在横跨飞机动力装置的超音速入口垂直于进入气流的片材（16）中。 正常的冲击使一部分光线弯曲（16）。 多个光纤端点的线性阵列收集离散的光样本。 将样品处理并与预定轮廓比较以确定冲击位置。

    PORTABLE HIGH GAIN FLUORESCENCE DETECTION SYSTEM
    9.
    发明申请
    PORTABLE HIGH GAIN FLUORESCENCE DETECTION SYSTEM 有权
    便携式高增益荧光检测系统

    公开(公告)号：US20120115214A1

    公开(公告)日：2012-05-10

    申请号：US13245124

    申请日：2011-09-26

    Applicant: C. Frederick Battrell ,  Troy D. Daiber

    Inventor： C. Frederick Battrell ,  Troy D. Daiber

    IPC: C12M1/34 ,  G01N21/64

    CPC classification number: G01N21/6456 ,  B01L7/52 ,  C12M23/16 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6454 ,  G01N2201/0245

    Abstract: An instrument for fluorometric assays in liquid samples is disclosed. The instrument may include multiple optical channels for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. The disclosed instrument finds utility in any number of applications, including microfluidic molecular biological assays based on PCR amplification of target nucleic acids and fluorometric assays in general.

    Abstract translation: 公开了用于液体样品中荧光测定的仪器。 仪器可以包括多个光学通道，用于监测与靶分析物相关联的第一荧光团和与对照相关联的第二荧光团。 所公开的仪器可用于任何数量的应用，包括基于目标核酸的PCR扩增和荧光测定的微流体分子生物学测定。

    Method and apparatus for normal shock sensing within the focal region of a laser beam
    10.
    发明授权
    Method and apparatus for normal shock sensing within the focal region of a laser beam 失效
    激光束聚焦区域内正常冲击检测的方法和装置

    公开(公告)号：US5424824A

    公开(公告)日：1995-06-13

    申请号：US061405

    申请日：1993-05-12

    Applicant: Troy D. Daiber ,  David C. Soreide

    Inventor： Troy D. Daiber ,  David C. Soreide

    IPC: F02C7/057 ,  G01P5/26 ,  G01P3/36 ,  F02B27/00 ,  F02C9/00

    CPC classification number: F02C7/057 ,  G01P5/26 ,  Y10T137/0645

    Abstract: A system using Lidar/Laser anemometry for measuring the position of the normal shock wave and air velocity in the inlet of a supersonic engine is described, A laser beam is focused over a region in the inlet where the shock is expected to be. Small particles in the inlet air each reflect the light which is Doppler shifted according to the air velocity in that point. The system and method utilizes the relative amplitude of two peaks in the Fourier transform of the optical return signal to determine if the position of the shock is within the focal region of the laser.

    Abstract translation: 描述了一种使用激光雷达/激光测风法测量超声波发动机入口中的正常冲击波位置和空气速度的系统。激光束聚焦在预期出现冲击的入口区域。 入口空气中的小颗粒每次都会反射出根据该点的空气速度多普勒偏移的光。 该系统和方法利用光学返回信号的傅立叶变换中的两个峰值的相对幅度来确定冲击的位置是否在激光器的聚焦区域内。

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