公开(公告)号：US20130090579A1

公开(公告)日：2013-04-11

申请号：US13648955

申请日：2012-10-10

Applicant: Charles A. Cain ,  Tzu-Yin Wang

Inventor： Charles A. Cain ,  Tzu-Yin Wang

IPC: A61N7/00

CPC classification number: A61N7/00

Abstract: Cavitation memory effects occur when remnants of cavitation bubbles (nuclei) persist in the host medium and act as seeds for subsequent events. In pulsed cavitational ultrasound therapy, or histotripsy, this effect may cause cavitation to repeatedly occur at these seeded locations within a target volume, producing inhomogeneous tissue fractionation or requiring an excess number of pulses to completely homogenize the target volume. Cavitation memory can be removed with a dithering technique. The spatial-temporal memory effect of micro-bubbles can be defeated by (1) passive temporal dithering, (2) active dithering, or (3) use of therapy pulses above the de novo threshold.

Abstract translation: 气蚀记忆效应发生在空泡气泡（核）残留在宿主介质中并作为后续事件的种子时发生。 在脉冲空化超声治疗或组织破裂中，这种作用可能导致在目标体积内的这些接种位置处重复发生空化，产生不均匀的组织分级或需要过量数量的脉冲以完全均化靶体积。 气蚀记忆可以用抖动技术去除。 微气泡的空间 - 时间记忆效应可以通过（1）被动时间抖动，（2）主动抖动或（3）使用高于从头阈值的治疗脉冲来消除。

公开(公告)号：US20130102932A1

公开(公告)日：2013-04-25

申请号：US13648965

申请日：2012-10-10

Applicant: Charles A. Cain ,  Tzu-Yin Wang

Inventor： Charles A. Cain ,  Tzu-Yin Wang

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61B2017/00274 ,  A61B2017/22008 ,  A61B2090/378 ,  A61B2090/3784 ,  A61N7/02

Abstract: Methods and devices for imaging tissue elasticity change as a tool to provide feedback for histotripsy treatments. Tissue lesion elasticity was measured with ultrasound shear wave elastography, where a quasi-planar shear wave was induced by acoustic radiation force generated by the therapeutic array, and tracked with ultrasound imaging at 3000 frames per second. Based on the shear wave velocity calculated from the sequentially captured frames, the Young's modulus in the lesion area was reconstructed. Results showed that the lesions were clearly identified on the elasticity images as an area with decreased elasticity. Lesions produced by histotripsy can be detected with high sensitivity using shear wave elastography. Decrease in the tissue elasticity corresponds well with the morphological and histological change.

Abstract translation: 用于成像组织弹性变化的方法和装置作为提供组织切除术治疗反馈的工具。 用超声波剪切波弹性成像法测量组织病变弹性，其中由治疗阵列产生的声辐射力引起准平面剪切波，并以每秒3000帧的超声波成像进行跟踪。 基于从顺序捕获的帧计算的剪切波速度，重建损伤区域的杨氏模量。 结果表明，弹性图像上的病变被清楚地识别为弹性下降的区域。 使用剪切波弹性成像可以高灵敏度检测组织破裂产生的病变。 组织弹性的降低与形态学和组织学变化有很好的对应关系。

公开(公告)号：US20110067624A1

公开(公告)日：2011-03-24

申请号：US12887705

申请日：2010-09-22

Applicant: CHARLES A. CAIN ,  Zhen Xu ,  Adam Maxwell ,  Tzu-Yin Wang ,  Simone Park

Inventor： CHARLES A. CAIN ,  Zhen Xu ,  Adam Maxwell ,  Tzu-Yin Wang ,  Simone Park

IPC: G01D21/00

CPC classification number: A61N7/02 ,  A61B8/587 ,  A61B2017/00721 ,  A61B2017/22008 ,  G09B23/286

Abstract: A cavitational ultrasound (e.g., Histotripsy) gel phantom and cavitational ultrasound testing system are provided that may include any of a number of features. One feature of the phantom and system is that it can allow for instant visual feedback on the efficacy and dosage of a Histotripsy transducer. The changes in the gel phantom can be visualized with the naked eye without having to wait for histology. The changes in the gel phantom can also be visualized with a camera, with ultrasound imaging, or with microscopy. In various embodiments, the phantom includes indicators such as carbon particles, dye-encapsulated beads, and red blood cells. Methods associated with use of the cavitational ultrasound gel phantom and testing system are also covered.

Abstract translation: 提供了可以包括多个特征中的任何一个的空穴超声（例如组织坏死）凝胶体模和空穴超声测试系统。 幻影和系统的一个特征是它可以允许对组织切片传感器的功效和剂量的即时视觉反馈。 凝胶幻影的变化可以用肉眼可视化，而无需等待组织学。 也可以用相机，超声波成像或显微镜观察凝胶体模的变化。 在各种实施方案中，幻影包括诸如碳颗粒，染料包封的珠粒和红细胞的指示剂。 还涉及与使用空穴超声凝胶幻影和测试系统相关的方法。

公开(公告)号：US08539813B2

公开(公告)日：2013-09-24

申请号：US12887705

申请日：2010-09-22

Applicant: Charles A. Cain ,  Zhen Xu ,  Adam Maxwell ,  Tzu-Yin Wang ,  Simone Park

Inventor： Charles A. Cain ,  Zhen Xu ,  Adam Maxwell ,  Tzu-Yin Wang ,  Simone Park

IPC: A61B8/00 ,  A61N7/00

CPC classification number: A61N7/02 ,  A61B8/587 ,  A61B2017/00721 ,  A61B2017/22008 ,  G09B23/286

Abstract: A cavitational ultrasound (e.g., Histotripsy) gel phantom and cavitational ultrasound testing system are provided that may include any of a number of features. One feature of the phantom and system is that it can allow for instant visual feedback on the efficacy and dosage of a Histotripsy transducer. The changes in the gel phantom can be visualized with the naked eye without having to wait for histology. The changes in the gel phantom can also be visualized with a camera, with ultrasound imaging, or with microscopy. In various embodiments, the phantom includes indicators such as carbon particles, dye-encapsulated beads, and red blood cells. Methods associated with use of the cavitational ultrasound gel phantom and testing system are also covered.

Abstract translation: 提供了可以包括多个特征中的任何一个的空穴超声（例如组织坏死）凝胶体模和空穴超声测试系统。 幻影和系统的一个特征是它可以允许对组织切片传感器的功效和剂量的即时视觉反馈。 凝胶幻影的变化可以用肉眼可视化，而无需等待组织学。 也可以用相机，超声波成像或显微镜观察凝胶体模的变化。 在各种实施方案中，幻影包括诸如碳颗粒，染料包封的珠粒和红细胞的指示剂。 还涉及与使用空穴超声凝胶幻影和测试系统相关的方法。