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    Apparatus and method for high throughput electrorotation analysis
    1.
    发明授权
    Apparatus and method for high throughput electrorotation analysis 有权
    用于高通量电磁分析的装置和方法

    公开(公告)号：US06448794B1

    公开(公告)日：2002-09-10

    申请号：US09643362

    申请日：2000-08-22

    Applicant: Jing Cheng ,  Junquan Xu ,  Xiaoshan Zhu ,  Litian Liu ,  Xiao-Bo Wang ,  Lei Wu

    Inventor： Jing Cheng ,  Junquan Xu ,  Xiaoshan Zhu ,  Litian Liu ,  Xiao-Bo Wang ,  Lei Wu

    IPC: G01R2708

    CPC classification number: G01N33/48707 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00587 ,  B01J2219/00596 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/0072 ,  Y10S436/806

    Abstract: The present invention concerns a high throughput electrorotation chip having an array of electrorotation units and methods of use thereof. To make the high throughput electrorotation chip, a plurality of electrorotation units (EU) are fabricated on a substrate or support and each EU is capable of producing a rotating electric field upon the application of an appropriate electrical signal. Exemplary embodiments include a row-column configuration of EUs having four electrode elements realized through two conductive-layers. The electrode elements may be linear, concave, or convex. Thin plates having one or multiple holes are bound to high-throughput electrorotation chips to form assay chambers having one or multiple wells. Particles can be introduced to the wells and electrorotation measurements can be performed on the particles. The high throughput electrorotation chip and chamber may be used for cell-based screening for leading drug candidate molecules from a compound library, for high-throughput characterizing particle electric properties, and for high-throughput assaying molecular compositions of unknown solutions.

    Abstract translation: 本发明涉及一种具有电极单元阵列的高通量电选机芯及其使用方法。 为了制造高通量电选芯片，在基板或支撑件上制造多个电极单元（EU），并且每个EU在施加适当的电信号时能够产生旋转电场。 示例性实施例包括具有通过两个导电层实现的四个电极元件的EU行的列列配置。 电极元件可以是线性的，凹的或凸的。 具有一个或多个孔的薄板结合到高通量电旋转切片以形成具有一个或多个孔的测定室。 可以将颗粒引入孔中，并且可以对颗粒进行电转化测量。 高通量电刺激芯片和腔室可用于来自化合物文库的主要药物候选分子的基于细胞的筛选，用于高通量表征颗粒电性质，以及用于高通量测定未知溶液的分子组成。

    Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation
    3.
    发明授权
    Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation 失效
    使用常规介电电泳和场流分馏的分级方法和设备

    公开(公告)号：US5993630A

    公开(公告)日：1999-11-30

    申请号：US604779

    申请日：1996-01-31

    Applicant: Frederick F. Becker ,  Peter R. C. Gascoyne ,  Ying Huang ,  Xiao-Bo Wang

    Inventor： Frederick F. Becker ,  Peter R. C. Gascoyne ,  Ying Huang ,  Xiao-Bo Wang

    IPC: B03C5/02 ,  G01N30/00 ,  G01N27/26 ,  G01N27/447

    CPC classification number: B03C5/028 ,  G01N30/0005 ,  G01N2030/0035 ,  G01N2030/0065

    Abstract: The present disclosure is directed to a novel apparatus and novel methods for the separtion, characterization, and manipulation of matter. In particular, the invention combines the use of frequency-dependent dielectric and conductive properties of particulate matter and solubilized matter with the properties of the suspending and transporting medium to discriminate and separate such matter. The apparatus includes a chamber having at least one electrode element and at least one inlet and one output port into which cells are introduced and removed from the chamber. Matter carried through the chamber in a fluid stream is then displaced within the fluid by a dielectrophoretic (DEP) force caused by the energized electrode. Following displacement within the fluid, matter travels through the chamber at velocities according to the velocity profile of the chamber. After the matter has transitted through the chamber, it exits at the opposite end of the chamber at a characteristic position. Methods according to the invention involve using the apparatus for discriminating and separating matter for research, diagnosis of a condition, and therapeutic purposes. Examples of such methods may include separation of mixtures of cells, such as cancer cells from normal cells, separation of parasitized erythrocytes from normal erythrocytes, separation of nucleic acids, and others.

    Abstract translation: 本公开涉及用于分离，表征和操纵物质的新型装置和新颖方法。 特别地，本发明结合了使用频率依赖的电介质和颗粒物质和溶解物质的导电性质与悬浮和输送介质的性质，以区分和分离这种物质。 该装置包括具有至少一个电极元件和至少一个入口和一个输出端口的腔室，细胞从腔室中被引入和移出。 然后通过流体流中的腔室进行的物质由通电电极引起的介电电泳（DEP）力在流体内移动。 在流体内移动之后，物质按照腔室的速度分布以速度行进通过腔室。 在物体经过腔室之后，它在特定位置处在腔室的相对端处离开。 根据本发明的方法涉及使用该装置来鉴别和分离用于研究，病症诊断和治疗目的的物质。 这些方法的实例可以包括分离细胞混合物，例如来自正常细胞的癌细胞，从正常红细胞分离寄生的红细胞，分离核酸等。

    Apparatus for switching and manipulating particles and method of use thereof
    6.
    发明授权
    Apparatus for switching and manipulating particles and method of use thereof 有权
    用于切换和操纵颗粒的装置及其使用方法

    公开(公告)号：US06596143B1

    公开(公告)日：2003-07-22

    申请号：US09678263

    申请日：2000-10-03

    Applicant: Xiao-Bo Wang ,  Weiping Yang ,  Junquan Xu ,  Jing Cheng ,  Lei Wu

    Inventor： Xiao-Bo Wang ,  Weiping Yang ,  Junquan Xu ,  Jing Cheng ,  Lei Wu

    IPC: G01N2726

    CPC classification number: H02N11/006 ,  B01D57/02 ,  B03C5/028 ,  H02N1/004

    Abstract: A device acts as a particle switch to transport and/or re-direct microparticles which are in a fluid suspension. The switch comprises at least three structural branches and the branches may be connected at a common junction. Particles can be transported along the branches as a result of the forces generated along that branch. Particles are transported into or out of the particle switch via the ends of the branches. Particles can be switched from one branch into one of the other branches. Depending on the properties of the particles, the transportation mechanism may be traveling-wave-dielectrophoresis or traveling-wave-electrophoresis.

    Abstract translation: 装置用作颗粒开关以运输和/或重新引导处于流体悬浮液中的微粒。 开关包括至少三个结构分支，并且分支可以在公共接头处连接。 由于沿该分支产生的力，颗粒可以沿着分支运输。 颗粒通过分支的末端被输送进出颗粒开关。 颗粒可以从一个分支切换到其他分支之一。 根据颗粒的性质，运输机制可以是行波介电电泳或行波电泳。

    Method and apparatus for fractionation using generalized dielectrophoresis and field flow fractionation
    7.
    发明授权
    Method and apparatus for fractionation using generalized dielectrophoresis and field flow fractionation 有权
    使用广义介电电泳和场流分馏法进行分馏的方法和装置

    公开(公告)号：US06287832B1

    公开(公告)日：2001-09-11

    申请号：US09395890

    申请日：1999-09-14

    Applicant: Frederick F. Becker ,  Peter R. C. Gascoyne ,  Ying Huang ,  Xiao-Bo Wang

    Inventor： Frederick F. Becker ,  Peter R. C. Gascoyne ,  Ying Huang ,  Xiao-Bo Wang

    IPC: C12N1300

    CPC classification number: G01N30/0005 ,  B03C5/028 ,  G01N2030/0035 ,  G01N2030/0065

    Abstract: The present disclosure is directed to a novel apparatus and novel methods for the separation, characterization, and manipulation of matter. In particular, the invention combines the use of frequency-dependent dielectric and conductive properties of particulate matter and solubilized matter with the properties of the suspending and transporting medium to discriminate and separate such matter. The apparatus includes a chamber having at least one electrode element and at least one inlet and one output port into which cells are introduced and removed from the chamber. Matter carried through the chamber in a fluid stream is then displaced within the fluid by a dielectrophoretic (DEP) force caused by the energized electrode. Following displacement within the fluid, matter travels through the chamber at velocities according to the velocity profile of the chamber. After the matter has transmitted through the chamber, it exits at the opposite end of the chamber at a characteristic position. Methods according to the invention involve using the apparatus for discriminating and separating matter for research, diagnosis of a condition, and therapeutic purposes. Examples of such methods may include separation of mixtures of cells, such as cancer cells from normal cells, separation of parasitized erythrocytes from normal erythrocytes, separation of nucleic acids, and others.

    Abstract translation: 本公开涉及用于分离，表征和操纵物质的新型装置和新颖方法。 特别地，本发明结合了使用频率依赖的电介质和颗粒物质和溶解物质的导电性质与悬浮和输送介质的性质，以区分和分离这种物质。 该装置包括具有至少一个电极元件和至少一个入口和一个输出端口的腔室，细胞从腔室中被引入和移出。 然后通过流体流中的腔室进行的物质由通电电极引起的介电电泳（DEP）力在流体内移动。 在流体内移动之后，物质按照腔室的速度分布以速度行进通过腔室。 在事件已经通过室之后，其在特定位置处在室的相对端处离开。 根据本发明的方法涉及使用该装置来鉴别和分离用于研究，病症诊断和治疗目的的物质。 这些方法的实例可以包括分离细胞混合物，例如来自正常细胞的癌细胞，从正常红细胞分离寄生的红细胞，分离核酸等。

    Generating Materialized Query Table Candidates
    8.
    发明申请
    Generating Materialized Query Table Candidates 失效
    生成物化查询表候选

    公开(公告)号：US20110196857A1

    公开(公告)日：2011-08-11

    申请号：US12702384

    申请日：2010-02-09

    Applicant: Dong Sheng Chen ,  Hong Min ,  Terence P. Purcell ,  Yefim Shuf ,  Xiao Bo Wang ,  Zhong Liang Zhang

    Inventor： Dong Sheng Chen ,  Hong Min ,  Terence P. Purcell ,  Yefim Shuf ,  Xiao Bo Wang ,  Zhong Liang Zhang

    IPC: G06F17/30

    CPC classification number: G06F17/30457

    Abstract: Techniques for generating a set of one or more materialized query table (MQT) candidates for a workload are provided. The techniques include receiving a workload, wherein the workload comprises a set of one or more queries, generating one or more best matching MQTs (BMQTs) based on one or more query blocks of the one or more queries by removing syntax that is not qualified for a MQT re-write, determining one or more frequently used multi-joins in the workload, using the one or more BMQTs and the one or more frequently used multi-joins to generate a set of one or more workload MQTs (WMQTs), and grouping one or more WMQTs and one or more BMQTs into one or more groups to merge into a set of a smaller number of MQTs and to cover the workload.

    Abstract translation: 提供了用于生成用于工作负载的一个或多个物化查询表（MQT）候选的集合的技术。 所述技术包括接收工作负载，其中所述工作负载包括一组一个或多个查询，基于所述一个或多个查询的一个或多个查询块生成一个或多个最佳匹配MQT（BMQT），通过除去不符合 MQT重写，使用所述一个或多个BMQT和所述一个或多个频繁使用的多连接来生成一组一个或多个工作负载MQT（WMQT）来确定所述工作负载中的一个或多个频繁使用的多连接，以及 将一个或多个WMQT和一个或多个BMQT分组成一个或多个组合并成一组较少数量的MQT并覆盖工作负载。

    Method and apparatus for fractionation using generalized dielectrophoresis and field flow fractionation
    9.
    发明授权
    Method and apparatus for fractionation using generalized dielectrophoresis and field flow fractionation 有权
    使用广义介电电泳和场流分馏法进行分馏的方法和装置

    公开(公告)号：US5993632A

    公开(公告)日：1999-11-30

    申请号：US243348

    申请日：1999-02-01

    Applicant: Frederick F. Becker ,  Peter R. C. Gascoyne ,  Ying Huang ,  Xiao-Bo Wang

    Inventor： Frederick F. Becker ,  Peter R. C. Gascoyne ,  Ying Huang ,  Xiao-Bo Wang

    IPC: B03C5/02 ,  G01N30/00 ,  G01N27/26

    CPC classification number: G01N30/0005 ,  B03C5/028 ,  G01N2030/0035 ,  G01N2030/0065

    Abstract: The present disclosure is directed to a novel apparatus and novel methods for the separation, characterization, and manipulation of matter. In particular, the invention combines the use of frequency-dependent dielectric and conductive properties of particulate matter and solubilized matter with the properties of the suspending and transporting medium to discriminate and separate such matter. The apparatus includes a chamber having at least one electrode element and at least one inlet and one output port into which cells are introduced and removed from the chamber. Matter carried through the chamber in a fluid stream is then displaced within the fluid by a dielectrophoretic (DEP) force caused by the energized electrode. Following displacement within the fluid, matter travels through the chamber at velocities according to the velocity profile of the chamber. After the matter has transitted through the chamber, it exists at the opposite end of the chamber at a characteristic position. Methods according to the invention involve using the apparatus for discriminating and separating matter for research, diagnosis of a condition, and therapeutic purposes. Examples of such methods may include separation of mixture of cells, such as cancer cells, separation of parasitized erythrocytes from normal erthrocytes, separation of nucleic acids, and others.

    Abstract translation: 本公开涉及用于分离，表征和操纵物质的新型装置和新颖方法。 特别地，本发明结合了使用频率依赖的电介质和颗粒物质和溶解物质的导电性质与悬浮和输送介质的性质，以区分和分离这种物质。 该装置包括具有至少一个电极元件和至少一个入口和一个输出端口的腔室，细胞从腔室中被引入和移出。 然后通过流体流中的腔室进行的物质由通电电极引起的介电电泳（DEP）力在流体内移动。 在流体内移动之后，物质按照腔室的速度分布以速度行进通过腔室。 在物体通过腔室转运之后，它在特定位置处存在于腔室的相对端。 根据本发明的方法涉及使用该装置来鉴别和分离用于研究，病症诊断和治疗目的的物质。 这种方法的实例可以包括细胞混合物的分离，例如癌细胞，寄生的红细胞与正常红细胞的分离，核酸的分离等。

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