公开(公告)号：US20060173019A1

公开(公告)日：2006-08-03

申请号：US11332786

申请日：2006-01-13

Applicant: Solomon Ungashe ,  Zheng Wei ,  Arindrajit Basak ,  Trevor Charvat ,  Jeff Jin ,  Jimmie Moore ,  Yibin Zang ,  Sreenivas Punna ,  Daniel Dairaghi ,  Derek Hansen ,  Andrew Pennell ,  John Wright

Inventor： Solomon Ungashe ,  Zheng Wei ,  Arindrajit Basak ,  Trevor Charvat ,  Jeff Jin ,  Jimmie Moore ,  Yibin Zang ,  Sreenivas Punna ,  Daniel Dairaghi ,  Derek Hansen ,  Andrew Pennell ,  John Wright

IPC: A61K31/496 ,  A61K31/4545 ,  C07D403/02 ,  C07D401/02

CPC classification number: C07C311/21 ,  C07D213/48 ,  C07D213/61 ,  C07D213/643 ,  C07D213/70 ,  C07D213/73 ,  C07D213/76 ,  C07D213/79 ,  C07D213/81 ,  C07D213/89 ,  C07D241/22 ,  C07D263/32 ,  C07D401/04 ,  C07D405/04 ,  C07D409/12 ,  C07D413/06 ,  C07D413/10 ,  C07D417/12 ,  C07D471/04

Abstract: Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.