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公开(公告)号：US08557597B2
公开(公告)日：2013-10-15
申请号：US13345032
申请日：2012-01-06
Applicant: Masakazu Akechi , Hirohisa Abe , Yoichi Fujiyama
Inventor： Masakazu Akechi , Hirohisa Abe , Yoichi Fujiyama
CPC classification number: G01N33/1846 , G01N27/06
Abstract: A total organic carbon measuring instrument including a measuring unit composed of, integrated together, organic substance oxidation part and carbon dioxide separation part and conductivity measuring part, control unit and data processing unit. In order to enhance the accuracy of conductivity measurement, the control unit is constructed so as to stop feeding of a sample water at the time of oxidation of organic substance and carry out feeding of the sample water at the time of sample water moving to the organic substance oxidation decomposition part and carbon dioxide separation part. The data processing unit is constructed so as to measure the total organic carbon concentration on the basis of conductivity at the time of arriving of sample water irradiated with ultraviolet rays of which relative intensity is a given value or higher at the carbon dioxide separation part.
Abstract translation: 一种总有机碳测量仪器，包括由有机物氧化部分和二氧化碳分离部分组成的测量单元和电导率测量部分，控制单元和数据处理单元。 为了提高电导率测量的准确性，控制单元构造成在有机物氧化时停止供给样品水，并在样品水移动到有机物时进行样品水的供给 物质氧化分解部分和二氧化碳分离部分。 数据处理单元被构造为基于在二氧化碳分离部分的相对强度为给定值或更高的紫外线照射的样品水到达时的电导率来测量总有机碳浓度。
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公开(公告)号：US07931865B2
公开(公告)日：2011-04-26
申请号：US12444563
申请日：2006-10-17
Applicant: Yoichi Fujiyama , Hirohisa Abe , Masakazu Akechi , Takeaki Inoue , Takeshi Iharada
Inventor： Yoichi Fujiyama , Hirohisa Abe , Masakazu Akechi , Takeaki Inoue , Takeshi Iharada
CPC classification number: G01N33/1846 , G01N27/06 , Y10T436/23 , Y10T436/235
Abstract: An apparatus which comprises: an organic-substance oxidation part in which organic substances contained in a sample water supplied are oxidized into carbon dioxide; a carbon dioxide separation part in which the carbon dioxide contained in the sample water is caused to permeate and come into a measurement water; and a conductivity measurement part in which the conductivity of the measurement water is measured. The carbon dioxide separation part comprises: a sample water channel in which sample water flows; an intermediate water part in which intermediate water having a higher pH value in a neutral region than the sample water is present; and a measurement water channel through which the measurement water comprising deionized water flows. The sample water channel is in contact with the intermediate water part through a gas-permeable membrane, and the intermediate water part is in contact with the measurement water channel through a gas-permeable membrane.
Abstract translation: 一种装置，包括：有机物质氧化部分，其中包含在供应的样品水中的有机物质被氧化成二氧化碳; 二氧化碳分离部，其中包含在样品水中的二氧化碳渗透并进入测量水; 测定测定水的电导率的电导率测定部。 二氧化碳分离部分包括：样品水流过的样品水通道; 中间水部分，其中存在在中性区域中具有比样品水更高的pH值的中间水; 以及包含去离子水的测量水流过的测量水通道。 样品水通道通过透气膜与中间水部分接触，中间水部分通过气体渗透膜与测量水通道接触。
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公开(公告)号：US20100034702A1
公开(公告)日：2010-02-11
申请号：US12532146
申请日：2007-03-20
Applicant: Masakazu Akechi , Hirohisa Abe , Yoichi Fujiyama
Inventor： Masakazu Akechi , Hirohisa Abe , Yoichi Fujiyama
IPC: G01N27/06
CPC classification number: G01N33/1846 , G01N27/06
Abstract: A total organic carbon measuring instrument including a measuring unit composed of, integrated together, organic substance oxidation part (24) and carbon dioxide separation part (20) and conductivity measuring part (34), control unit (40) and data processing unit (41). In order to enhance the accuracy of conductivity measurement, the control unit (40) is constructed so as to stop feeding of a sample water at the time of oxidation of organic substance and carry out feeding of the sample water at the time of sample water moving to the organic substance oxidation decomposition part (20) and carbon dioxide separation part (24). The data processing unit (41) is constructed so as to measure the total organic carbon concentration on the basis of conductivity at the time of arriving of sample water irradiated with ultraviolet rays of which relative intensity is a given value or higher at the carbon dioxide separation part (24).
Abstract translation: 一种总有机碳测量仪器，包括由有机物质氧化部分（24）和二氧化碳分离部分（20）组成的测量单元和电导率测量部分（34），控制单元（40）和数据处理单元（41） ）。 为了提高电导率测量的精度，控制单元（40）被构造成在有机物氧化时停止供给样品水，并在样品水移动时进行样品水的供给 有机物氧化分解部（20）和二氧化碳分离部（24）。 数据处理单元（41）被构造为基于在二氧化碳分离时相对强度为给定值或更高的紫外线照射的样品水到达时的电导率来测量总有机碳浓度 第（24）部分。
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公开(公告)号：US20090114293A1
公开(公告)日：2009-05-07
申请号：US12091293
申请日：2005-10-25
Applicant: Masaki Kanai , Yoichi Fujiyama , Masakazu Akechi
Inventor： Masaki Kanai , Yoichi Fujiyama , Masakazu Akechi
CPC classification number: G01N21/05 , B01L3/502707 , B01L2200/0689 , B01L2200/147 , B01L2300/0816 , B01L2300/0877 , B01L2300/0887 , B01L2300/12 , B29C65/4815 , B29C65/5057 , B29C66/1122 , B29C66/53461 , B29C66/71 , B29C66/91214 , B29C66/91221 , B29C66/91317 , B29C66/91411 , B29C66/919 , B29C66/91921 , B29C66/91931 , B29C66/91933 , B29C66/91941 , B29C66/91943 , B29K2027/12 , B29L2031/756 , B32B37/182 , B32B38/04 , B32B2038/047 , B32B2457/00 , G01N27/44721 , G01N27/453 , G01N30/74 , G01N2021/0346 , Y10T137/8593 , Y10T156/10
Abstract: To provide a flow cell that is free from liquid leakage and excels in chemical resistance. There is provided a preferred form of flow cell comprising flat-plate glass substrate (3); adherent fluororesin sheet (5) having a groove as flow channel (7) made by cutting machining; and glass substrate (1) as lid member furnished with through-holes (9, 11) as fluid inlet and outlet at positions corresponding to both end portions of the groove. The fluororesin sheet (5) is interposed between the glass substrates (1, 3) and, while heating at a temperature not lower than the melting point of the fluororesin sheet (5), pressurized so that the glass substrates (1, 3) are bonded together by the fluororesin sheet (5) per se. Flow channel member (17) is constructed by the glass substrate (3) and, bonded thereonto, the fluororesin sheet (5).
Abstract translation: 提供没有液体泄漏的流动池并且具有优异的耐化学性。 提供了包括平板玻璃基板（3）的流动池的优选形式; 具有通过切削加工形成的作为流路（7）的槽的粘附性氟树脂片（5） 玻璃基板（1）作为具有通孔（9,11）的盖构件，作为与凹槽的两个端部对应的位置处的流体入口和出口。 氟树脂片（5）插入在玻璃基板（1,3）之间，在不低于氟树脂片（5）的熔点的温度下加热，加压使玻璃基板（1,3）为 通过氟树脂片（5）本身粘合在一起。 流路构件（17）由玻璃基板（3）构成并与氟树脂片（5）粘合。
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公开(公告)号：US20090004061A1
公开(公告)日：2009-01-01
申请号：US11770080
申请日：2007-06-28
Applicant: Yoichi FUJIYAMA , Masakazu Akechi , Masaki Kanai
Inventor： Yoichi FUJIYAMA , Masakazu Akechi , Masaki Kanai
IPC: B01J8/00
CPC classification number: G01N27/07 , C02F1/32 , C02F1/42 , C02F2103/04 , C02F2209/05 , C02F2209/20 , G01N33/1846 , Y10T436/235
Abstract: Disclosed is a total organic carbon (TOC) measurement apparatus capable of facilitating reduction in size of the apparatus and achieving enhanced measurement accuracy. The TOC measurement apparatus includes an organics oxidation unit, a carbon-dioxide separation unit and a conductivity measurement unit, which are integrally formed by laminating a plurality of plates to define therebetween and incorporate therein an oxidizing flow passage, an aqueous-sample flow passage, a gas permeable membrane, a measurement-water flow passage and a conductivity measuring electrode. The TOC measurement apparatus is designed such that carbon oxide in an aqueous sample is transferred from the aqueous-sample flow passage to the measurement-water flow passage through the gas permeable membrane, and a conductivity of measurement water which contains the carbon oxide and flows through a flow passage facing the conductivity measuring electrode is determined and converted to a TOC content.
Abstract translation: 公开了一种总体有机碳（TOC）测量装置，其能够便于减小装置的尺寸并实现提高的测量精度。 TOC测量装置包括有机氧化单元，二氧化碳分离单元和电导率测量单元，它们通过层压多个板而形成在其间并在其中结合有氧化流动通道，水样品流动通道， 透气膜，测量 - 水流通道和电导率测量电极。 TOC测量装置被设计成使得水样品中的碳氧化物从水样品流动通道通过透气膜转移到测量水流动通道，并且包含含有碳氧化物并流过的测量水的电导率 确定面向导电性测量电极的流动通道并将其转换为TOC含量。
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Patent Agency Ranking
6.发明申请Gas Exchange Chip, Method Of Gas Extraction Using The Same, And Total Organic Carbon Measuring Instrument 有权气体交换芯片，使用其的气体提取方法和总有机碳测量仪器公开(公告)号：US20080085216A1
公开(公告)日：2008-04-10
申请号：US11794728
申请日：2005-12-28
Applicant: Masakazu Akechi , Yoichi Fujiyama , Hirohisa Abe , Masaki Kanai
Inventor： Masakazu Akechi , Yoichi Fujiyama , Hirohisa Abe , Masaki Kanai
CPC classification number: B01D19/00 , B01D19/0021 , B01D67/0032 , B01D71/50 , B01D2323/04 , B01D2323/28 , B01J2219/00905 , G01N1/4005 , G01N33/1846 , G01N2001/4016 , Y10T436/2575
Abstract: A gas exchange chip comprises substrates (1,2); two flow channels (3,4) formed in the substrates (1,2) and each having an inlet port and an outlet port; and multiple grooves (9) interlinking the flow channels (3,4). The grooves (9) have the size of their sectional area predetermined and have at least a part of the internal surface thereof rendered hydrophobic so as to permit the transfer of gas component while inhibiting any liquid passage. A sample water containing carbon dioxide is caused to flow through one of the flow channels (3) while pure water is caused to flow through the other flow channel (4) to thereby transfer the carbon dioxide contained in the sample water into the pure water.
Abstract translation: 气体交换芯片包括基板（1,2）; 形成在基板（1,2）中并且各自具有入口和出口的两个流动通道（3,4） 以及多个沟槽（9），其连接流动通道（3,4）。 凹槽（9）具有预定的截面面积的尺寸，并且其内表面的至少一部分变得疏水，从而允许气体成分的转移，同时抑制任何液体通道。 使含有二氧化碳的样品水流过其中一个流动通道（3），同时使纯水流过另一个流动通道（4），从而将样品水中所含的二氧化碳转移到纯水中。
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公开(公告)号：US06559940B2
公开(公告)日：2003-05-06
申请号：US09748170
申请日：2000-12-27
Applicant: Yoichi Fujiyama
Inventor： Yoichi Fujiyama
IPC: G01N110
CPC classification number: G01N21/05 , G01N2021/0346 , G01N2201/064
Abstract: A measuring cell is formed of base plates joined together. A passage groove is formed on a joining surface of one base plate. Through-holes for introducing and discharging a fluid sample are formed on the other base plate, and the joining surface is provided with an optically opaque Si film as slits. Further, the joining surfaces of the base plates and the inner surface of the passage groove are covered with SiO2 films. Thus, a measuring cell having a sufficiently small passage sectional area, a high air-tightness, a chemically stable measuring chamber, and a high measuring sensitivity can be obtained.
Abstract translation: 测量单元由连接在一起的基板形成。 在一个基板的接合面上形成通道槽。 在另一个基板上形成用于引入和排出流体样品的通孔，并且接合表面设置有不透光的Si膜作为狭缝。 此外，基板的接合面和通道槽的内表面被SiO 2膜覆盖。 因此，可以获得具有足够小的通道截面积，高气密性，化学稳定的测量室和高测量灵敏度的测量池。
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公开(公告)号：US07993586B2
公开(公告)日：2011-08-09
申请号：US11770080
申请日：2007-06-28
Applicant: Yoichi Fujiyama , Masakazu Akechi , Masaki Kanai
Inventor： Yoichi Fujiyama , Masakazu Akechi , Masaki Kanai
CPC classification number: G01N27/07 , C02F1/32 , C02F1/42 , C02F2103/04 , C02F2209/05 , C02F2209/20 , G01N33/1846 , Y10T436/235
Abstract: Disclosed is a total organic carbon (TOC) measurement apparatus capable of facilitating reduction in size of the apparatus and achieving enhanced measurement accuracy. The TOC measurement apparatus includes an organics oxidation unit, a carbon-dioxide separation unit and a conductivity measurement unit, which are integrally formed by laminating a plurality of plates to define therebetween and incorporate therein an oxidizing flow passage, an aqueous-sample flow passage, a gas permeable membrane, a measurement-water flow passage and a conductivity measuring electrode. The TOC measurement apparatus is designed such that carbon oxide in an aqueous sample is transferred from the aqueous-sample flow passage to the measurement-water flow passage through the gas permeable membrane, and a conductivity of measurement water which contains the carbon oxide and flows through a flow passage facing the conductivity measuring electrode is determined and converted to a TOC content.
Abstract translation: 公开了一种总体有机碳（TOC）测量装置，其能够便于减小装置的尺寸并实现提高的测量精度。 TOC测量装置包括有机氧化单元，二氧化碳分离单元和电导率测量单元，它们通过层压多个板而形成在其间并在其中结合有氧化流动通道，水样品流动通道， 透气膜，测量 - 水流通道和电导率测量电极。 TOC测量装置被设计成使得水样品中的碳氧化物从水样品流动通道通过透气膜转移到测量水流动通道，并且包含含有碳氧化物并流过的测量水的电导率 确定面向导电性测量电极的流动通道并将其转换为TOC含量。
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公开(公告)号：US20110003359A1
公开(公告)日：2011-01-06
申请号：US12865837
申请日：2009-02-03
Applicant: Yoichi Fujiyama , Yoichi Tagawa , Shunsuke Kobayashi
Inventor： Yoichi Fujiyama , Yoichi Tagawa , Shunsuke Kobayashi
IPC: C12N11/00
CPC classification number: C12M23/34 , A61M1/3689 , C12M25/02
Abstract: Disclosed is a biodevice which has a porous membrane (8) and flow paths (10) and (12) formed therein. In a preferred embodiment, the flow path (10) and the flow path (12) are opposed to each other with the porous membrane (8) being interposed between them. The flow path (10) serves as a first reaction chamber through which a first solution is allowed to pass so as to be brought into contact with one of the surfaces of the porous membrane (8). The flow path (12) serves as a second reaction chamber through which a second solution is allowed to pass so as to be brought into contact with the other surface of the porous membrane (8). In the flow path (10), first cells are immobilized on the porous membrane (8). In the flow path (12), second cells are immobilized on the porous membrane (8).
Abstract translation: 公开了一种生物装置，其具有形成在其中的多孔膜（8）和流路（10）和（12）。 在优选实施例中，流动路径（10）和流动路径（12）彼此相对，多孔膜（8）插入在它们之间。 流路（10）用作第一反应室，通过该第一反应室使第一溶液通过以与多孔膜（8）的一个表面接触。 流路（12）用作第二反应室，通过该第二反应室使第二溶液通过以与多孔膜（8）的另一表面接触。 在流路（10）中，将第一细胞固定在多孔膜（8）上。 在流路（12）中，将第二细胞固定在多孔膜（8）上。
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公开(公告)号：US20120107947A1
公开(公告)日：2012-05-03
申请号：US13345032
申请日：2012-01-06
Applicant: Masakazu Akechi , Hirohisa Abe , Yoichi Fujiyama
Inventor： Masakazu Akechi , Hirohisa Abe , Yoichi Fujiyama
IPC: G01N27/00
CPC classification number: G01N33/1846 , G01N27/06
Abstract: A total organic carbon measuring instrument including a measuring unit composed of, integrated together, organic substance oxidation part and carbon dioxide separation part and conductivity measuring part, control unit and data processing unit. In order to enhance the accuracy of conductivity measurement, the control unit is constructed so as to stop feeding of a sample water at the time of oxidation of organic substance and carry out feeding of the sample water at the time of sample water moving to the organic substance oxidation decomposition part and carbon dioxide separation part. The data processing unit is constructed so as to measure the total organic carbon concentration on the basis of conductivity at the time of arriving of sample water irradiated with ultraviolet rays of which relative intensity is a given value or higher at the carbon dioxide separation part.
Abstract translation: 一种总有机碳测量仪器，包括由有机物氧化部分和二氧化碳分离部分组成的测量单元和电导率测量部分，控制单元和数据处理单元。 为了提高电导率测量的准确性，控制单元构造成在有机物氧化时停止供给样品水，并在样品水移动到有机物时进行样品水的供给 物质氧化分解部分和二氧化碳分离部分。 数据处理单元被构造为基于在二氧化碳分离部分的相对强度为给定值或更高的紫外线照射的样品水到达时的电导率来测量总有机碳浓度。
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