Method of purifying a biological composition and article therefor

    公开(公告)号:US10562997B2

    公开(公告)日:2020-02-18

    申请号:US15549268

    申请日:2016-03-17

    Abstract: A method of purifying a biological composition includes: disposing loose cationic ligand-functionalized staple fibers and a biological composition within a mixing volume of a vessel; agitating the biological composition and the loose cationic ligand-functionalized staple fibers while they are in intimate contact with each other within the mixing volume to provide modified fibers and a purified biological composition; and separating at least a portion of the purified biological composition from the modified fibers and any loose cationic ligand-functionalized staple fibers with which it is in contact. The loose cationic ligand-functionalized staple fibers have a modified surface layer comprising a grafted acrylic polymer comprising 10 to 100 percent by weight of a cationically-ionizable monomer unit. An article for purifying a biological composition includes: a vessel having a mixing volume disposed therein; and the loose cationic ligand-functionalized staple fibers disposed within the mixing volume.

    CONSTRUCTIONS FOR FLUID MEMBRANE SEPARATION DEVICES
    8.
    发明申请
    CONSTRUCTIONS FOR FLUID MEMBRANE SEPARATION DEVICES 审中-公开
    流体膜分离装置的结构

    公开(公告)号:US20150343388A1

    公开(公告)日:2015-12-03

    申请号:US14649348

    申请日:2013-12-13

    Abstract: Described herein is a construction comprising (a) a support sheet having a base, comprising (i) a plurality of rails extending from the base wherein each rail of the plurality of rails extends continuously down a length of the support sheet and each rail comprises a first side surface and an opposing second side surface and a top surface; and (ii) a plurality of first protrusions extending from the base, wherein the plurality of first protrusions are located between the plurality of rails; and (b) a selectively permeable membrane having a first major membrane surface contacting at least the top surface of at least two rails enclosing a flow channel having a height extending between the base of the support sheet and the first major membrane surface, wherein the plurality of protrusions change the height of the flow channel along its length along the longitudinal axis of the flow channel.

    Abstract translation: 本文描述的是一种结构,其包括(a)具有基座的支撑片,包括(i)从基座延伸的多个轨道,其中多个轨道中的每个轨道沿支撑片材的长度连续地延伸,并且每个轨道包括 第一侧表面和相对的第二侧表面和顶表面; 和(ii)从所述基座延伸的多个第一突起,其中所述多个第一突起位于所述多个轨道之间; 和(b)具有第一主要膜表面的选择性渗透膜,所述第一主膜表面至少与至少两个轨道的顶表面接触,所述至少两个轨道包围具有在所述支撑片材的基底和所述第一主要膜表面之间延伸的高度的流动通道, 的突起沿着流道的纵向轴线沿其长度改变流动通道的高度。

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