公开(公告)号：US12220235B2

公开(公告)日：2025-02-11

申请号：US16774909

申请日：2020-01-28

Applicant: Abbott Diabetes Care Inc.

Inventor： Tianmei Ouyang ,  Benjamin J. Feldman ,  Hyun Cho ,  Lam N. Tran ,  Stephen Oja ,  Namvar Kiaie

IPC: A61B5/1486 ,  A61B5/00 ,  A61B5/145 ,  B60K28/06 ,  C12Q1/30 ,  C12Q1/32

Abstract: Multiple enzymes may be present in one or more active areas of an electrochemical analyte sensor for detecting one or more different analytes. In particular, an analyte sensor may comprise a sensor tail configured for insertion into a tissue and one or more working electrodes having a glucose-responsive active area and an ethanol-responsive active area to detect glucose and ethanol in vivo.

公开(公告)号：US20240272113A1

公开(公告)日：2024-08-15

申请号：US18422910

申请日：2024-01-25

Applicant: ABBOTT DIABETES CARE INC.

Inventor： Tianmei Ouyang ,  Benjamin J. Feldman

IPC: G01N27/327 ,  C08F220/54 ,  C08F226/06

CPC classification number: G01N27/3272 ,  C08F220/54 ,  C08F226/06

Abstract: The present disclosure provides membrane structures that exhibit low temperature sensitivity. Analyte sensors including said membranes are also provided herein. The present disclosure further provides methods of detecting analytes using said sensors.

公开(公告)号：US12048539B2

公开(公告)日：2024-07-30

申请号：US16774841

申请日：2020-01-28

Applicant: Abbott Diabetes Care Inc.

Inventor： Stephen Oja ,  Tianmei Ouyang ,  Hyun Cho ,  Benjamin J. Feldman ,  Namvar Kiaie

IPC: A61B5/1486 ,  A61B5/145 ,  C12Q1/00

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  C12Q1/002 ,  C12Q1/005 ,  G01N2333/9029 ,  G01N2333/904 ,  G01N2333/908

Abstract: Multiple enzymes may be present in the active area(s) of an electrochemical sensor to facilitate analysis of one or more analytes. The multiple enzymes may function independently to detect several analytes or in concert to detect a single analyte. One sensor configuration includes a first active area and a second active area, where the first active area has an oxidation-reduction potential that is sufficiently separated from the oxidation-reduction potential of the second active area to allow independent signal production. Some sensor configurations may have an active area overcoated with a multi-component membrane containing two or more different membrane polymers. Sensor configurations having multiple enzymes capable of interacting in concert include those in which a first enzyme converts an analyte into a first product and a second enzyme converts the first product into a second product, thereby generating a signal at a working electrode that is proportional to the analyte concentration.

公开(公告)号：US20220192550A1

公开(公告)日：2022-06-23

申请号：US17348169

申请日：2021-06-15

Applicant: ABBOTT DIABETES CARE INC.

Inventor： Udo Hoss ,  Tianmei Ouyang ,  Benjamin J. Feldman ,  Suyue Qian

IPC: A61B5/1486 ,  A61B5/145

Abstract: Analyte sensor comprises an electrode layer having an elongate body comprising a proximal end and a distal end. The electrode layer includes a first active working electrode area, a second electrode portion, and at least one gap electrically separating the first active working electrode portion and the second electrode portion. The first active working electrode area comprises at least one sensing spot with at least one analyte responsive enzyme disposed thereupon. Additional analyte sensors disclosed.

公开(公告)号：US20220056500A1

公开(公告)日：2022-02-24

申请号：US17403258

申请日：2021-08-16

Applicant: Abbott Diabetes Care Inc.

Inventor： Tianmei Ouyang ,  Benjamin J. Feldman

IPC: C12Q1/00 ,  C12Q1/26 ,  G01N27/327 ,  C12N11/082 ,  G01N33/573 ,  G01N33/66

Abstract: NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

公开(公告)号：US20210260257A1

公开(公告)日：2021-08-26

申请号：US17179660

申请日：2021-02-19

Applicant: ABBOTT DIABETES CARE INC.

Inventor： Jonathan D. McCanless ,  Benjamin J. Feldman

IPC: A61L31/16 ,  A61B5/145 ,  A61B5/00 ,  A61L31/08

Abstract: A sensor control device and methods of making them are described. The sensor control device includes an electronics housing and a plug assembly. The electronics housing includes an upper shell matable to a lower mount having a skin-facing surface. The plug assembly is coupled to the electronics housing and includes a sensor module that has a sensor and a sharp module having a sharp. The plug assembly includes a base having a skin-facing surface and a plug portion comprising a lumen therethrough. At least a portion of a surface of the electronics housing or the plug assembly comprises an antimicrobial agent. The antimicrobial agent may be a metal and/or a metal oxide.

公开(公告)号：US20210000416A1

公开(公告)日：2021-01-07

申请号：US17031548

申请日：2020-09-24

Applicant: ABBOTT DIABETES CARE INC.

Inventor： Jean-Pierre Cole ,  Benjamin J. Feldman ,  Udo Hoss ,  Namvar Kiaie ,  Frederic T. Arbogast

IPC: A61B5/00 ,  G16H20/60 ,  G16H40/63 ,  A61B5/024 ,  A61B5/145 ,  A61B5/11

Abstract: Systems, devices and methods are provided for the monitoring and management of an individual's wellness and nutrition using analyte data from an in vivo analyte sensor. Generally, a sensor control device is provided for wear on the body. The sensor control device can include an in vivo analyte sensor for measuring an analyte level in a bodily fluid, an accelerometer for measuring the physical activity level of the subject, as well as communications circuitry for wirelessly transmitting data to a reader device. Furthermore, disclosed herein are embodiments of various graphical user interfaces for displaying analyte metrics on a reader device, comparing the analyte response of various foods and/or meals, modifying daily nutrient recommendations based on analyte metrics and physical activity level measurements, and other features described herein. Additionally, the embodiments disclosed herein can be used to monitor various types of analytes.

公开(公告)号：US10859525B2

公开(公告)日：2020-12-08

申请号：US15964217

申请日：2018-04-27

Applicant: Abbott Diabetes Care Inc.

Inventor： Benjamin J. Feldman ,  Zenghe Liu ,  Tianmei Ouyang ,  Suyue Qian

IPC: G01N27/327 ,  C12Q1/00

Abstract: Provided are sensors for determining the concentration of an analyte in a sample fluid. In certain embodiments, the sensors include conductive particles and exhibit improved uniformity of distribution of one or more sensing chemistry components, increased effective working electrode surface area, and/or reduced entry of interfering components into a sample chamber of the sensor. Methods of using and manufacturing the sensors are also provided.

公开(公告)号：US20200237277A1

公开(公告)日：2020-07-30

申请号：US16774909

申请日：2020-01-28

Applicant: Abbott Diabetes Care Inc.

Inventor： Tianmei Ouyang ,  Benjamin J. Feldman ,  Hyun Cho ,  Lam N. Tran ,  Stephen Oja ,  Mark K. Sloan ,  Ashwin Kumar ,  Namvar Kiaie ,  Michael R. Love

IPC: A61B5/1486 ,  C12Q1/30 ,  C12Q1/32 ,  A61B5/145 ,  B60K28/06

Abstract: Multiple enzymes may be present in one or more active areas of an electrochemical analyte sensor for detecting one or more different analytes. In particular, an analyte sensor may comprise a sensor tail configured for insertion into a tissue and one or more working electrodes having a glucose-responsive active area and an ethanol-responsive active area to detect glucose and ethanol in vivo.

公开(公告)号：US20200205706A1

公开(公告)日：2020-07-02

申请号：US16815791

申请日：2020-03-11

Applicant: Abbott Diabetes Care Inc.

Inventor： Benjamin J. Feldman ,  Zenghe Liu

IPC: A61B5/145 ,  A61B5/1486

Abstract: An analyte sensor comprising: an insertion tip configured for insertion below a tissue of a user, the insertion tip comprising: a working electrode comprising a sensing layer disposed thereon and a membrane layer disposed at least partially over the sensing layer; a substrate; and a counter electrode. Wherein a polymer layer comprising at least an immunosuppressant is disposed on an exterior surface of the working electrode, the substrate, or the counter electrode, the polymer layer being separate from the sensing layer and the membrane layer.