公开(公告)号：US20160022617A1

公开(公告)日：2016-01-28

申请号：US14775972

申请日：2014-03-14

Applicant: ABBOTT LABORATORIES

Inventor： Menghua Luo ,  Suzette Pereira ,  Neile Edens ,  Gerard Davis ,  Susan Gawel ,  Raj Chandran

IPC: A61K31/19 ,  G01N33/68

CPC classification number: A61K31/19 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2333/4704 ,  G01N2333/575 ,  G01N2800/52

Abstract: Insulin resistance biomarkers and related methods of using the biomarkers are provided. The biomarkers may be blood biomarkers and include C-peptide, Insulin-Like Growth Factor-Binding Protein 2 (IGFBP-2), and Leptin. Also provided is a method of reducing the effect of prolonged physical inactivity on insulin resistance in a subject who is experiencing prolonged physical inactivity, or who is expected to experience prolonged physical inactivity in the near future.

Abstract translation: 提供了使用生物标志物的胰岛素抵抗生物标志物和相关方法。 生物标志物可以是血液生物标志物，包括C肽，胰岛素样生长因子结合蛋白2（IGFBP-2）和瘦蛋白。 还提供了一种减少长期身体不活动对经历长时间身体不活动的受试者或预期在不久的将来会经历长时间身体不活动的受试者的胰岛素抵抗的影响的方法。

公开(公告)号：US10775388B2

公开(公告)日：2020-09-15

申请号：US15106223

申请日：2015-02-05

Applicant: MEDIMMUNE, LLC ,  ABBOTT LABORATORIES

Inventor： Partha S. Chowdhury ,  Reena Varkey ,  Meina Liang ,  Yen-Wah Lee ,  Katie Streicher ,  Koustubh Ranade ,  Ethan Grant ,  Lydia Greenlees ,  Yihong Yao ,  Melissa Parker ,  Gerard Davis ,  Nicolette Jeanblanc ,  Susan Brophy ,  Bruce Dille

IPC: G01N33/68 ,  C07K16/18 ,  A61P11/06 ,  A61P17/00 ,  A61P11/00 ,  A61K9/00 ,  A61K31/137 ,  A61K31/56 ,  A61K31/58 ,  A61K39/395 ,  C07K16/24 ,  C07K16/28 ,  A61K39/00

Abstract: This disclosure provides a robust, sensitive, and specific assay for the detection and measurement of periostin levels in samples obtained from human patients having, or suspected of having an IL-13-mediated disease or disorder. The disclosure further provides novel antiperiostin monoclonal antibodies that recognize at least isoforms 1, 2, 3, 4, 7, and 8 of human periostin, and assay kits comprising one or more of these antibodies.

公开(公告)号：US20180196065A1

公开(公告)日：2018-07-12

申请号：US15106223

申请日：2015-02-05

Applicant: MEDIMMUNE, LLC ,  ABBOTT LABORATORIES

Inventor： Partha Chowdhury ,  Reena Varkey ,  Meina Liang ,  Yen-Wah Lee ,  Katie Streicher ,  Koustubh Ranade ,  Ethan Grant ,  Lydia Greenlees ,  Yihong Yao ,  Melissa Parker ,  Gerard Davis ,  Nicolette Jeanblanc ,  Susan Brophy ,  Bruce Dille

IPC: G01N33/68 ,  A61P11/06 ,  A61P11/00 ,  A61P17/00 ,  C07K16/24 ,  C07K16/28 ,  A61K31/56 ,  A61K31/58 ,  A61K31/137 ,  A61K39/395 ,  A61K9/00 ,  C07K16/18

Abstract: This disclosure provides a robust, sensitive, and specific assay for the detection and measurement of periostin levels in samples obtained from human patients having, or suspected of having an IL-13-mediated disease or disorder. The disclosure further provides novel antiperiostin monoclonal antibodies that recognize at least isoforms 1, 2, 3, 4, 7, and 8 of human periostin, and assay kits comprising one or more of these antibodies.

公开(公告)号：US09713598B2

公开(公告)日：2017-07-25

申请号：US14775972

申请日：2014-03-14

Applicant: ABBOTT LABORATORIES

Inventor： Menghua Luo ,  Suzette Pereira ,  Neile Edens ,  Gerard Davis ,  Susan Gawel ,  Raj Chandran

IPC: A61K31/19 ,  G01N33/68

CPC classification number: A61K31/19 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2333/4704 ,  G01N2333/575 ,  G01N2800/52

Abstract: Insulin resistance biomarkers and related methods of using the biomarkers are provided. The biomarkers may be blood biomarkers and include C-peptide, Insulin-Like Growth Factor-Binding Protein 2 (IGFBP-2), and Leptin. Also provided is a method of reducing the effect of prolonged physical inactivity on insulin resistance in a subject who is experiencing prolonged physical inactivity, or who is expected to experience prolonged physical inactivity in the near future.