公开(公告)号：US09938589B2

公开(公告)日：2018-04-10

申请号：US15642992

申请日：2017-07-06

Applicant: Abbott Laboratories ,  The Regents of the University of California

Inventor： Charles Chiu ,  Deanna Lee ,  Michael Berg ,  George Dawson ,  Kelly Coller ,  Kevin Cheng ,  John R. Hackett, Jr. ,  Matthew Frankel ,  Kenn Forberg

IPC: C07K14/005 ,  C12Q1/70 ,  G01N33/569 ,  A61K49/08

CPC classification number: C12Q1/701 ,  A61K49/085 ,  C07K14/005 ,  C12N2770/24022 ,  G01N33/56983 ,  G01N2333/183 ,  G01N2469/20

Abstract: Provided herein are compositions, methods, and kits for detecting human Pegivirus 2 (HPgV-2). In certain embodiments, provided herein are HPgV-2 specific nucleic acid probes and primers, and methods for detecting HPgV-2 nucleic acid. In other embodiments, provided herein are HPgV-2 immunogenic composition compositions, methods of treating a subject with immunogenic HPgV-2 peptides, and methods of detecting HPgV-2 subject antibodies in a sample.

公开(公告)号：US20170306426A1

公开(公告)日：2017-10-26

申请号：US15642992

申请日：2017-07-06

Applicant: Abbott Laboratories ,  The Regents of the University of California

Inventor： Charles Chiu ,  Deanna Lee ,  Michael Berg ,  George Dawson ,  Kelly Coller ,  Kevin Cheng ,  John R. Hackett, JR. ,  Matthew Frankel ,  Kenn Forberg

IPC: C12Q1/70 ,  C07K14/005 ,  G01N33/569

CPC classification number: C12Q1/701 ,  A61K49/085 ,  C07K14/005 ,  C12N2770/24022 ,  G01N33/56983 ,  G01N2333/183 ,  G01N2469/20

Abstract: Provided herein are compositions, methods, and kits for detecting human Pegivirus 2 (HPgV-2). In certain embodiments, provided herein are HPgV-2 specific nucleic acid probes and primers, and methods for detecting HPgV-2 nucleic acid. In other embodiments, provided herein are HPgV-2 immunogenic composition compositions, methods of treating a subject with immunogenic HPgV-2 peptides, and methods of detecting HPgV-2 subject antibodies in a sample.

公开(公告)号：US20240210431A1

公开(公告)日：2024-06-27

申请号：US18557610

申请日：2022-04-29

Applicant: ABBOTT LABORATORIES

Inventor： Matthew Frankel ,  Patrick Fritchie ,  Gregg Williams ,  Bradley Weston

IPC: G01N35/02 ,  G01N35/04 ,  G01N35/10

CPC classification number: G01N35/025 ,  G01N35/1081 ,  G01N2035/0444

Abstract: Systems and methods for onboard pooling of samples for high-throughput analysis of the samples. Including a sample loading area for receiving a plurality of sample tubes, and a sample transport configured to continually transport individual vessels along a transport path from a sample dispense position to a sample capture and transfer position, with intermediate positions therebetween. At least one pipettor to transfer a first and second samples from the sample loading area to the sample transport and to pool the first sample and the second sample in a vessel on the sample transport to form a pooled sample. A sample transfer mechanism to capture at least a fractionated portion of the pooled sample from the vessel at the sample capture and transfer position and to transfer the at least a fractionated portion of the pooled sample for high-throughput analysis.

公开(公告)号：US20180230555A1

公开(公告)日：2018-08-16

申请号：US15893120

申请日：2018-02-09

Applicant: Abbott Laboratories ,  The Regents of the University of California

Inventor： Charles Chiu ,  Deanna Lee ,  Michael Berg ,  George Dawson ,  Kelly Coller ,  Kevin Cheng ,  John R. Hackett, JR. ,  Matthew Frankel ,  Kenn Forberg

IPC: C12Q1/70 ,  G01N33/569 ,  C07K14/005 ,  A61K49/08

Abstract: Provided herein are compositions, methods, and kits for detecting human Pegivirus 2 (HPgV-2). In certain embodiments, provided herein are HPgV-2 specific nucleic acid probes and primers, and methods for detecting HPgV-2 nucleic acid. In other embodiments, provided herein are HPgV-2 immunogenic composition compositions, methods of treating a subject with immunogenic HPgV-2 peptides, and methods of detecting HPgV-2 subject antibodies in a sample.

公开(公告)号：US20150376722A1

公开(公告)日：2015-12-31

申请号：US14752262

申请日：2015-06-26

Applicant: Abbott Laboratories ,  The Regents of the University of California

Inventor： Charles Chiu ,  Deanna Lee ,  Michael Berg ,  George Dawson ,  Kelly Coller ,  Kevin Cheng ,  John Hackett ,  Matthew Frankel ,  Kenn Forberg

IPC: C12Q1/70 ,  C07K14/005 ,  C12N7/00 ,  G01N33/569

CPC classification number: C12Q1/701 ,  A61K49/085 ,  C07K14/005 ,  C12N2770/24022 ,  G01N33/56983 ,  G01N2333/183 ,  G01N2469/20

Abstract: Provided herein are compositions, methods, and kits for detecting human Pegivirus 2 (HPgV-2). In certain embodiments, provided herein are HPgV-2 specific nucleic acid probes and primers, and methods for detecting HPgV-2 nucleic acid. In other embodiments, provided herein are HPgV-2 immunogenic composition compositions, methods of treating a subject with immunogenic HPgV-2 peptides, and methods of detecting HPgV-2 subject antibodies in a sample.

Abstract translation: 本文提供了用于检测人Pegivirus 2（HPgV-2）的组合物，方法和试剂盒。 在某些实施方案中，本文提供的是HPgV-2特异性核酸探针和引物，以及用于检测HPgV-2核酸的方法。 在其它实施方案中，本文提供了HPgV-2免疫原性组合物组合物，用免疫原性HPgV-2肽治疗受试者的方法，以及检测样品中的HPgV-2受试者抗体的方法。

公开(公告)号：US20240279749A1

公开(公告)日：2024-08-22

申请号：US18557631

申请日：2022-04-29

Applicant: ABBOTT LABORATORIES

Inventor： Matthew Frankel ,  Patrick Fritchie ,  Gregg Williams ,  Bradley Weston

IPC: C12Q1/70 ,  B01L3/00 ,  C12Q1/6806 ,  C12Q1/6848 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

CPC classification number: C12Q1/70 ,  B01L3/502 ,  C12Q1/6806 ,  C12Q1/6848 ,  G01N35/0099 ,  G01N35/025 ,  B01L2200/0647 ,  B01L2200/141 ,  B01L2300/0829 ,  G01N2035/0406 ,  G01N2035/041 ,  G01N2035/0446 ,  G01N2035/103

Abstract: The presently disclosed subject matter relates to methods for rapid, sensitive, and high-throughput nucleic acid testing of biological samples, e.g., blood, serum, or plasma samples from donors, as well as systems capable of performing such high-throughput nucleic acid testing.

公开(公告)号：US09777340B2

公开(公告)日：2017-10-03

申请号：US14752262

申请日：2015-06-26

Applicant: Abbott Laboratories ,  The Regents of the University of California

Inventor： Charles Chiu ,  Deanna Lee ,  Michael Berg ,  George Dawson ,  Kelly Coller ,  Kevin Cheng ,  John Hackett ,  Matthew Frankel ,  Kenn Forberg

IPC: C07K14/005 ,  C12Q1/70 ,  G01N33/569

CPC classification number: C12Q1/701 ,  A61K49/085 ,  C07K14/005 ,  C12N2770/24022 ,  G01N33/56983 ,  G01N2333/183 ,  G01N2469/20

Abstract: Provided herein are compositions, methods, and kits for detecting human Pegivirus 2 (HPgV-2). In certain embodiments, provided herein are HPgV-2 specific nucleic acid probes and primers, and methods for detecting HPgV-2 nucleic acid. In other embodiments, provided herein are HPgV-2 immunogenic composition compositions, methods of treating a subject with immunogenic HPgV-2 peptides, and methods of detecting HPgV-2 subject antibodies in a sample.