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公开(公告)号：US20230263834A1
公开(公告)日：2023-08-24
申请号：US18006765
申请日：2021-07-26
Applicant: Abbott Laboratories
Abstract: A method of preventing, reducing, or delaying the onset of fatty liver disease in a subject comprises enterally administering intact bovine milk-derived exosomes consisting of endogenous cargo to a subject in need thereof in an amount effective to reduce hepatic lipid accumulation. In a specific embodiment, the intact bovine milk-derived exosomes consisting of endogenous cargo can be administered in an amount effective to reduce de novo lipogenesis in the subject. The intact bovine milk-derived exosomes consisting of endogenous cargo can be administered to the subject directly or in a nutritional composition.
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公开(公告)号：US20230293561A1
公开(公告)日：2023-09-21
申请号：US18006802
申请日：2021-07-26
Applicant: ABBOTT LABORATORIES
Inventor： Manuel MANZANO , Enrique HERNANDEZ , José María LÓPEZ PEDROSA , Ricardo RUEDA CABRERA , Rachael BUCK
IPC: A61K31/702 , A61K45/06 , A61P3/06 , A61K9/00 , A61P1/16
CPC classification number: A61K31/702 , A61K45/06 , A61P3/06 , A61K9/0053 , A61P1/16
Abstract: A method of reducing or delaying the onset of fatty liver disease in a subject comprises enterally administering at least one human milk oligosaccharide (HMO) to a subject in need thereof in an amount effective to reduce hepatic lipid accumulation. In a specific embodiment, the at least one HMO is administered in an amount effective to reduce de novo lipogenesis in the subject. The at least one HMO can be administered to the subject directly or in a nutritional composition.
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3.发明公开公开(公告)号：US20230263178A1
公开(公告)日：2023-08-24
申请号：US17907750
申请日：2021-04-01
Applicant: Abbott Laboratories
CPC classification number: A23C9/1425 , A23L33/40 , A61P3/10 , A61K35/20
Abstract: A method of obtaining an exosome-enriched product comprises providing a whey-containing bovine milk fraction, conducting a first centrifugation of the whey-containing bovine milk fraction to obtain a whey middle fraction, conducting a second centrifugation of the whey middle fraction at an increased speed to obtain a concentrated whey fraction, filtering the concentrated whey fraction to obtain a filtered whey fraction, and conducting a third centrifugation of the filtered whey fraction at a further increased speed to obtain an exosome-enriched product. The exosome-enriched product comprises intact exosomes and less than 5 wt % casein based on the total weight of protein in the exosome-enriched product. Nutritional compositions comprise protein, carbohydrate, and/or fat, and exosomes provided by addition of the exosome-enriched product. A method of improving insulin sensitivity in a subject comprises administering a nutritional composition comprising the exosome-enriched product.
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公开(公告)号：US20240009245A1
公开(公告)日：2024-01-11
申请号：US18253073
申请日：2021-11-17
Applicant: ABBOTT LABORATORIES
IPC: A61K35/20 , A23C9/142 , A23L33/00 , A23L33/10 , B01D61/14 , A61K9/127 , A61K47/42 , A61K47/18 , A61P19/00
CPC classification number: A61K35/20 , A23C9/1425 , A23L33/40 , A23L33/10 , B01D61/147 , B01D61/145 , B01D61/149 , A61K9/1276 , A61K47/42 , A61K47/183 , A61P19/00 , A23C2210/206 , B01D2315/16
Abstract: A method of increasing height in a pediatric subject comprises enterally administering an exosome-enriched product comprising intact bovine milk-derived exosomes to the pediatric subject in need thereof. A method of promoting linear bone growth in a pediatric subject comprises enterally administering an exosome-enriched product comprising intact bovine milk-derived exosomes to the pediatric subject in need thereof. A method of obtaining an exosome-enriched product from cheese whey comprises subjecting the cheese whey to microfiltration (MF), ultrafiltration (UF), and diafiltration (DF) steps, wherein the MF, UF, and DF steps employ, successively, membranes with cut off values which gradually decrease in size with each filtration step, wherein the cheese whey is sweet cheese whey and has a pH from about 6.0 to about 6.5.
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Patent Agency Ranking
公开(公告)号：US20230110977A1
公开(公告)日：2023-04-13
申请号：US17802716
申请日：2021-02-26
Applicant: ABBOTT LABORATORIES
IPC: A61K31/702 , A61K31/7004 , A61K31/7016 , A61K31/718 , A61P19/08 , A23L33/125 , A23L33/24
Abstract: A method of promoting bone health in a moderately malnourished individual is provided. The method includes treating the moderately malnourished individual with a nutritional composition that contains a carbohydrate blend. The carbohydrate blend includes a source of at least one carbohydrate that provides rapidly available glucose, a source of at least one carbohydrate that provides slowly available glucose, and a source of at least one non-digestible carbohydrate or resistant starch.
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6.发明公开公开(公告)号：US20240285689A1
公开(公告)日：2024-08-29
申请号：US18259881
申请日：2021-12-20
Applicant: ABBOTT LABORATORIES
Abstract: A method of enhancing muscle performance in a subject in need of improved physical performance comprises administering an exosome-enriched product comprising intact bovine milk-derived exosomes to the subject in need thereof. A method of reducing chronic fatigue in a subject recovering or recovered from a viral infection comprises administering an exosome-enriched product comprising intact bovine milk-derived exosomes to the subject.
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公开(公告)号：US20230255928A1
公开(公告)日：2023-08-17
申请号：US17996793
申请日：2021-04-23
Applicant: Abbott Laboratories
Inventor： Suzette PEREIRA , Ricardo RUEDA CABRERA , Vikkie MUSTAD
IPC: A61K31/353 , A61P7/00 , A23L33/105 , A23L33/00 , A23L33/19 , A23L33/185 , A23L33/175 , A23L33/125 , A23L33/115
CPC classification number: A61K31/353 , A61P7/00 , A23L33/105 , A23L33/40 , A23L33/19 , A23L33/185 , A23L33/175 , A23L33/125 , A23L33/115
Abstract: Methods of increasing microvascular blood flow in the muscle of a human subject comprise orally administering about 100 to about 800 mg cocoa flavanols per day in a nutritional composition comprising at least one source of protein, to a subject in need of increased microvascular blood flow in the muscle.
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公开(公告)号：US20240065997A1
公开(公告)日：2024-02-29
申请号：US18552726
申请日：2022-03-31
Applicant: ABBOTT LABORATORIES
Inventor： José María LÓPEZ PEDROSA , Ricardo RUEDA CABRERA , Manuel MANZANO
IPC: A61K31/198 , A61K31/047 , A61K47/26 , A61K47/42 , A61K47/44 , A61P3/10
CPC classification number: A61K31/198 , A61K31/047 , A61K47/26 , A61K47/42 , A61K47/44 , A61P3/10
Abstract: A method of improving insulin production in a subject in need thereof comprises administering a nutritional composition comprising lysine, arginine, and beta-hydroxy-beta-methylbutyrate (HMB) to the subject. A method of improving insulin secretion in a subject in need thereof comprises administering a nutritional composition comprising lysine, arginine, and HMB to the subject. A nutritional composition comprises about 0.01 to about 15 wt % HMB, about 0.03 to about 40 wt % lysine, and about 0.02 to about wt % arginine.
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公开(公告)号：US20240058386A1
公开(公告)日：2024-02-22
申请号：US18259874
申请日：2021-12-20
Applicant: ABBOTT LABORATORIES
Abstract: A method of improving joint health in a subject in need thereof comprises administering an exosome-enriched product comprising intact bovine milk-derived exosomes to the subject in need thereof.
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