公开(公告)号：US20180311342A1

公开(公告)日：2018-11-01

申请号：US15964674

申请日：2018-04-27

Applicant: AJINOMOTO CO., INC.

Inventor： Kayo MATSUMOTO ,  Wataru KUROSAWA ,  Kenji TANAKA ,  Takuya SEKI ,  Hiroshi UMISHIO

IPC: A61K39/39 ,  C07C323/60 ,  C07C323/59 ,  C07C323/52

CPC classification number: C07C323/00 ,  A61K45/00 ,  C07C237/22 ,  C07C257/14 ,  C07C271/22 ,  C07C275/16 ,  C07C279/12 ,  C07C279/14 ,  C07C323/60 ,  C07D201/00 ,  C07D295/00

Abstract: The present invention aims to provide an immunostimulating agent superior in an immunostimulatory effect, particularly a compound useful as a vaccine adjuvant, a pharmaceutical composition containing the compound, a vaccine containing the compound and an antigen.An immunostimulating agent containing at least one kind of a compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a salt thereof.

公开(公告)号：US20160046592A1

公开(公告)日：2016-02-18

申请号：US14928409

申请日：2015-10-30

Applicant: Ajinomoto Co., Inc.

Inventor： Kayo MATSUMOTO ,  Wataru MIYANAGA ,  Mizuki DOHI ,  Tadakiyo NAKAGAWA ,  Kaori KOBAYASHI ,  Sen TAKESHITA

IPC: C07D307/79 ,  C07D207/16 ,  C07C323/18 ,  C07D239/26 ,  C07D213/40 ,  C07D207/06 ,  C07D211/98 ,  C07D263/32 ,  C07D405/12 ,  C07D407/12

CPC classification number: C07D307/79 ,  A61K31/198 ,  A61K31/275 ,  A61K31/343 ,  A61K31/351 ,  A61K31/40 ,  A61K31/401 ,  A61K31/4025 ,  A61K31/4402 ,  A61K31/4409 ,  A61K31/4525 ,  C07C323/18 ,  C07C2601/14 ,  C07D207/06 ,  C07D207/16 ,  C07D211/26 ,  C07D211/58 ,  C07D211/98 ,  C07D213/40 ,  C07D231/12 ,  C07D233/64 ,  C07D239/26 ,  C07D249/08 ,  C07D261/08 ,  C07D263/32 ,  C07D271/06 ,  C07D271/10 ,  C07D277/28 ,  C07D295/125 ,  C07D295/192 ,  C07D309/04 ,  C07D333/48 ,  C07D405/12 ,  C07D407/12

Abstract: An object is to provide a novel compound which has a glycogen synthase activation ability, but activates a receptor PPAR to a low degree and is highly safe. Provided is a compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof: wherein Ar1 represents any one of the following rings (II) and (III): wherein R2 represents an alkyl group, and R3 represents a hydrogen atom or an alkyl group, and R1 represents any one of the following substituents (IV) and (V):

Abstract translation: 目的是提供具有糖原合成酶活化能力但能够低度活化受体PPAR的高度安全的新型化合物。 提供由以下通式（I）表示的化合物或其药学上可接受的盐：其中Ar 1表示以下环（II）和（III）中的任一个：其中R 2表示烷基，R 3表示氢原子 或烷基，R1表示以下取代基（Ⅳ）和（Ⅴ）中的任意一种：

公开(公告)号：US20150099733A1

公开(公告)日：2015-04-09

申请号：US14567506

申请日：2014-12-11

Applicant: AJINOMOTO CO., INC.

Inventor： Takahiro KOSHIBA ,  Munetaka TOKUMASU ,  Taisuke ICHIMARU ,  Koji OHSUMI ,  Tadakiyo NAKAGAWA ,  Tatsuhiro YAMADA ,  Kayo MATSUMOTO ,  Tamotsu SUZUKI

IPC: C07D333/40 ,  C07D409/12 ,  C07D409/06

CPC classification number: A61K31/381 ,  A61K31/19 ,  A61K31/396 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4436 ,  A61K31/4535 ,  A61K31/4725 ,  A61K38/05 ,  C07D319/12 ,  C07D333/38 ,  C07D333/40 ,  C07D409/06 ,  C07D409/12

Abstract: Compounds represented by the following formula (I); wherein each symbol is as defined in the specification, are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.

Abstract translation: 由下式（I）表示的化合物; 其中每个符号如说明书中所定义，可用作具有丝氨酸蛋白酶抑制作用的高血糖抑制剂和用作糖尿病的预防或治疗药物。