公开(公告)号：US20150037359A1

公开(公告)日：2015-02-05

申请号：US14381199

申请日：2013-02-27

Applicant: AMUNIX OPERATING, INC.

Inventor： Volker Schellenberger ,  Vladimir Podust ,  Chia-Wei Wang ,  Bryant McLaughlin ,  Bee-Cheng Sim ,  Sheng Ding ,  Chen Gu

IPC: A61K47/48 ,  A61K38/24

CPC classification number: A61K38/24 ,  A61K47/64 ,  A61K49/0032 ,  A61K49/0052 ,  A61K49/0056 ,  C07K5/0205

Abstract: The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.

Abstract translation: 本发明涉及延伸的重组多肽（XTEN）组合物，包含与用于与药理活性有效载体缀合的交联剂连接的XTEN和XTEN的缀合物组合物，制备高度纯化的XTEN的方法，制备XTEN-接头和XTEN-有效载体缀合物的方法 以及使用XTEN-交联剂和XTEN-有效载体组合物的方法。

公开(公告)号：US10953073B2

公开(公告)日：2021-03-23

申请号：US16133444

申请日：2018-09-17

Applicant: Amunix Operating Inc.

Inventor： Volker Schellenberger ,  Vladimir Podust ,  Chia-Wei Wang ,  Bryant McLaughlin ,  Bee-Cheng Sim ,  Sheng Ding ,  Chen Gu

IPC: A61K38/24 ,  A61K47/64 ,  C07K5/02 ,  A61K49/00

Abstract: The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.

公开(公告)号：US20190083577A1

公开(公告)日：2019-03-21

申请号：US16133444

申请日：2018-09-17

Applicant: Amunix Operating Inc.

Inventor： Volker Schellenberger ,  Vladimir Podust ,  Chia-Wei Wang ,  Bryant MCLAUGHLIN ,  Bee-Cheng Sim ,  Sheng Ding ,  Chen Gu

IPC: A61K38/24 ,  A61K47/64 ,  C07K5/02 ,  A61K49/00

Abstract: The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.

公开(公告)号：US10172953B2

公开(公告)日：2019-01-08

申请号：US14381199

申请日：2013-02-27

Applicant: Amunix Operating Inc.

Inventor： Volker Schellenberger ,  Vladimir Podust ,  Chia-Wei Wang ,  Bryant McLaughlin ,  Bee-Cheng Sim ,  Sheng Ding ,  Chen Gu

IPC: A61K47/00 ,  A61K47/48 ,  C07K5/02 ,  A61K49/00 ,  A61K38/24 ,  A61K47/64

Abstract: The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.