公开(公告)号：US10316336B2

公开(公告)日：2019-06-11

申请号：US15605930

申请日：2017-05-25

Applicant: API Intellectual Property Holdings, LLC

Inventor： Shrikant Survase ,  Ryan Zebroski ,  Georgios Adamos ,  Vesa Pylkkanen

IPC: C12P7/10 ,  C12P7/04 ,  C12P7/16 ,  C12P7/28 ,  C12P7/52 ,  C12P7/54 ,  C12P19/02 ,  C12P19/14

Abstract: This invention provides optimized fermentation of cellulosic and hemicellulosic sugars. Biomass-derived hemicellulosic and cellulosic sugars are independently conditioned and separately fermented, utilizing reuse and recycle of microorganisms, metabolic intermediates, and nutrients. Conditioned sugars can be fermented in separate vessels, where excess cells from glucose fermentation are conveyed to hemicellulose sugar fermentation along with raffinate from solvent recovery, to enhance productivity and product yield. Some variations provide a method of fermenting C5 and C6 sugars to fermentation products, the method comprising: fermenting a C6-rich sugar feed to a first fermentation product; fermenting a C5-rich sugar feed to a second fermentation product; removing microorganism cells from the first fermentor, to maintain a cell concentration within a selected range; conveying microorganism cells to a second fermentor; and removing microorganism cells from the second fermentor, to maintain a microorganism cell concentration that is greater than that in the C6-rich fermentor.