公开(公告)号：US11630098B2

公开(公告)日：2023-04-18

申请号：US16917474

申请日：2020-06-30

Applicant: ARIZONA BOARD OF REGENTS on behalf of ARIZONA STATE UNIVERSITY

Inventor： Stuart Lindsay ,  Peiming Zhang ,  Yanan Zhao

IPC: G01N33/487

Abstract: A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length LI and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than L2, but less than or equal to the sum of LI and L2.

公开(公告)号：US20200333321A1

公开(公告)日：2020-10-22

申请号：US16917474

申请日：2020-06-30

Applicant: ARIZONA BOARD OF REGENTS on behalf of ARIZONA STATE UNIVERSITY

Inventor： Stuart Lindsay ,  Peiming Zhang ,  Yanan Zhao

IPC: G01N33/487

Abstract: A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length LI and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than L2, but less than or equal to the sum of LI and L2.

公开(公告)号：US20200033320A1

公开(公告)日：2020-01-30

申请号：US16537232

申请日：2019-08-09

Applicant: ARIZONA BOARD OF REGENTS on behalf of ARIZONA STATE UNIVERSITY

Inventor： Stuart Lindsay ,  Peiming Zhang ,  Yanan Zhao

IPC: G01N33/487

Abstract: A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length L1 and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than L2, but less than or equal to the sum of L1 and L2.

公开(公告)号：US10422787B2

公开(公告)日：2019-09-24

申请号：US15797052

申请日：2017-10-30

Applicant: ARIZONA BOARD OF REGENTS on behalf of ARIZONA STATE UNIVERSITY

Inventor： Stuart Lindsay ,  Peiming Zhang ,  Yanan Zhao

IPC: G01N27/327 ,  G01N33/487 ,  G01N27/447

Abstract: A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length L1 and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than 2L1, but less than or equal to the sum of 2L1 and L2.

公开(公告)号：US20240345065A1

公开(公告)日：2024-10-17

申请号：US18604115

申请日：2024-03-13

Applicant: ARIZONA BOARD OF REGENTS on behalf of ARIZONA STATE UNIVERSITY

Inventor： Stuart Lindsay ,  Peiming Zhang ,  Yanan Zhao

IPC: G01N33/487 ,  G01N27/327

CPC classification number: G01N33/48721 ,  G01N27/3276 ,  G01N27/3278

Abstract: A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length L1 and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than L2, but less than or equal to the sum of L1 and L2.

公开(公告)号：US11959905B2

公开(公告)日：2024-04-16

申请号：US18178130

申请日：2023-03-03

Applicant: ARIZONA BOARD OF REGENTS on behalf of ARIZONA STATE UNIVERSITY

Inventor： Stuart Lindsay ,  Peiming Zhang ,  Yanan Zhao

IPC: G01N27/327 ,  G01N33/487

CPC classification number: G01N33/48721 ,  G01N27/3276 ,  G01N27/3278

Abstract: A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length LI and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than L2, but less than or equal to the sum of LI and L2.

公开(公告)号：US20230243807A1

公开(公告)日：2023-08-03

申请号：US18178130

申请日：2023-03-03

Applicant: ARIZONA BOARD OF REGENTS ON behalf of ARIZONA STATE UNIVERSITY

Inventor： Stuart Lindsay ,  Peiming Zhang ,  Yanan Zhao

IPC: G01N27/327

CPC classification number: G01N27/3276

Abstract: A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length LI and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than L2, but less than or equal to the sum of LI and L2.

公开(公告)号：US10379102B2

公开(公告)日：2019-08-13

申请号：US15375901

申请日：2016-12-12

Applicant: ARIZONA BOARD OF REGENTS on behalf of ARIZONA STATE UNIVERSITY

Inventor： Stuart Lindsay ,  Peiming Zhang ,  Yanan Zhao

IPC: G01N27/327 ,  G01N33/487

Abstract: A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length L1 and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than L2, but less than or equal to the sum of L1 and L2.