公开(公告)号：US20160139390A1

公开(公告)日：2016-05-19

申请号：US14941214

申请日：2015-11-13

Applicant: AVEDRO, INC.

Inventor： Michael A. Bukshtab ,  Marc D. Friedman

IPC: G02B21/00 ,  A61B3/14 ,  G02B17/00 ,  A61B3/13

CPC classification number: G02B21/0056 ,  A61B3/13 ,  A61B3/14 ,  A61B5/0068 ,  A61B5/0075 ,  G01B9/02044 ,  G01J3/00 ,  G02B17/006 ,  G02B21/0048

Abstract: An example system determines biomechanical properties of eye tissue. The system includes a confocal microscopy system configured to scan the incident light across a plurality of cross-sections of the tissue. The incident light is reflected by the plurality of cross-sections of tissue as scattered light. The system includes a spectrometer to receive the scattered light and provide spectral information for the scattered light. The system includes processor(s) to determine a Brillouin frequency shift from the spectral information and to generate a three-dimensional profile of the corneal tissue according to the Brillouin frequency shift. The three-dimensional profile provides an indicator of one or more biomechanical properties of the tissue. The spectrometer includes a multipass optical device that generates an interference pattern from the scattered light. The interference pattern provides the spectral information for the scattered light. The spectrometer includes a camera to detect the interference pattern from the optical device.

Abstract translation: 示例系统确定眼组织的生物力学性质。 该系统包括共焦显微镜系统，其配置成扫描穿过组织的多个横截面的入射光。 入射光被组织的多个横截面反射为散射光。 该系统包括用于接收散射光并提供散射光的光谱信息的光谱仪。 该系统包括从光谱信息确定布里渊频移并且根据布里渊频移产生角膜组织的三维轮廓的处理器。 三维轮廓提供组织的一种或多种生物力学性质的指示物。 光谱仪包括从散射光产生干涉​​图案的多光学光学装置。 干涉图形为散射光提供光谱信息。 光谱仪包括用于检测来自光学装置的干涉图案的照相机。

公开(公告)号：US10114205B2

公开(公告)日：2018-10-30

申请号：US14941214

申请日：2015-11-13

Applicant: Avedro, Inc.

Inventor： Michael A. Bukshtab ,  Marc D. Friedman

IPC: A61B3/14 ,  G01J3/00 ,  G02F1/01 ,  G02B27/00 ,  G02B1/10 ,  G02B5/28 ,  G02B21/00 ,  A61B5/00 ,  G01B9/02 ,  A61B3/13 ,  G02B17/00

Abstract: An example system determines biomechanical properties of eye tissue. The system includes a confocal microscopy system configured to scan the incident light across a plurality of cross-sections of the tissue. The incident light is reflected by the plurality of cross-sections of tissue as scattered light. The system includes a spectrometer to receive the scattered light and provide spectral information for the scattered light. The system includes processor(s) to determine a Brillouin frequency shift from the spectral information and to generate a three-dimensional profile of the corneal tissue according to the Brillouin frequency shift. The three-dimensional profile provides an indicator of one or more biomechanical properties of the tissue. The spectrometer includes a multipass optical device that generates an interference pattern from the scattered light. The interference pattern provides the spectral information for the scattered light. The spectrometer includes a camera to detect the interference pattern from the optical device.