公开(公告)号：US12092647B2

公开(公告)日：2024-09-17

申请号：US17099668

申请日：2020-11-16

Applicant: Abbott Laboratories

Inventor： Beth McQuiston ,  Justin Rogers ,  Jaime Marino ,  Raj Chandran ,  Tianming Zhang ,  Saul Datwyler

IPC: G01N33/68 ,  A61B5/00 ,  A61B5/055 ,  A61B6/03 ,  A61B6/50

CPC classification number: G01N33/6893 ,  A61B5/0042 ,  A61B5/055 ,  A61B6/03 ,  G01N33/6896 ,  A61B6/032 ,  A61B6/501 ,  G01N2333/914 ,  G01N2333/918 ,  G01N2800/28 ,  G01N2800/40 ,  G01N2800/60

Abstract: Disclosed herein are methods that aid in the determination of whether to perform imaging, such as magnetic resonance imaging (MRI) or computerized tomography (CT) scan, on a human subject that has sustained or may have sustained an injury to the head using an early biomarker, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof. These methods involve detecting levels and changes in levels of UCH-L1 in samples taken from a human subject at time points within 24 hours after the subject has sustained or may have sustained an injury to the head.

公开(公告)号：US20210088533A1

公开(公告)日：2021-03-25

申请号：US17099668

申请日：2020-11-16

Applicant: Abbott Laboratories

Inventor： Beth McQuiston ,  Justin Rogers ,  Jaime Marino ,  Raj Chandran ,  Tianming Zhang ,  Saul Datwyler

IPC: G01N33/68 ,  A61B5/00 ,  A61B5/055

Abstract: Disclosed herein are methods that aid in the determination of whether to perform imaging, such as magnetic resonance imaging (MM) or computerized tomography (CT) scan, on a human subject that has sustained or may have sustained an injury to the head using an early biomarker, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof. These methods involve detecting levels and changes in levels of UCH-L1 in samples taken from a human subject at time points within 24 hours after the subject has sustained or may have sustained an injury to the head.

公开(公告)号：US20250020665A1

公开(公告)日：2025-01-16

申请号：US18792630

申请日：2024-08-02

Applicant: Abbott Laboratories

Inventor： Beth McQuiston ,  Justin Rogers ,  Jaime Marino ,  Raj Chandran ,  Tianming Zhang ,  Saul Datwyler

IPC: G01N33/68 ,  A61B5/00 ,  A61B5/055 ,  A61B6/03 ,  A61B6/50

Abstract: Disclosed herein are methods that aid in the determination of whether to perform imaging, such as magnetic resonance imaging (MRI) or computerized tomography (CT) scan, on a human subject that has sustained or may have sustained an injury to the head using an early biomarker, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof. These methods involve detecting levels and changes in levels of UCH-L1 in samples taken from a human subject at time points within 24 hours after the subject has sustained or may have sustained an injury to the head.