公开(公告)号：US20210164961A1

公开(公告)日：2021-06-03

申请号：US16733781

申请日：2020-01-03

Applicant: Agilent Technologies, Inc.

Inventor： Xiaobo Wang ,  Yama A. Abassi ,  Biao Xi ,  Wen Fu Zhang ,  Xiao Xu

IPC: G01N33/483 ,  G01N33/487

Abstract: A system for monitoring cell-substrate impedance of excitable cells at millisecond time resolution and methods of assessing cell beating by monitoring cell-substrate impedance of beating cells at millisecond time resolution.

公开(公告)号：US20240210379A1

公开(公告)日：2024-06-27

申请号：US18401197

申请日：2023-12-29

Applicant: Agilent Technologies, Inc.

Inventor： Xiaobo Wang ,  Yama A. Abassi ,  Biao Xi ,  Wen Fu Zhang ,  Xiao Xu

IPC: G01N33/483 ,  G01N27/02 ,  G01N33/487 ,  G01N33/543

CPC classification number: G01N33/4836 ,  G01N27/02 ,  G01N33/4833 ,  G01N33/48728 ,  G01N33/5438

Abstract: A system for monitoring cells, which includes a device for monitoring cell-substrate impedance, the device having a plurality of wells on a nonconductive substrate, where each of the plurality of wells has an electrode array fabricated on the substrate for measurement of cell-substrate impedance; an impedance analyzer that measures cell-substrate impedance from the plurality of wells; electronic circuitry with multiple analogue-to-digital conversion channels, where the electronic circuitry electrically connects the electrode arrays to the impedance analyzer such that the electrode arrays are electrically monitored at millisecond time resolution; and a software program that analyzes the measured cell-substrate impedance.

公开(公告)号：US11360072B2

公开(公告)日：2022-06-14

申请号：US16733781

申请日：2020-01-03

Applicant: Agilent Technologies, Inc.

Inventor： Xiaobo Wang ,  Yama A. Abassi ,  Biao Xi ,  Wen Fu Zhang ,  Xiao Xu

IPC: G01N33/483 ,  G01N33/487 ,  G01N33/543 ,  G01N27/02

Abstract: A system for monitoring cell-substrate impedance of excitable cells at millisecond time resolution and methods of assessing cell beating by monitoring cell-substrate impedance of beating cells at millisecond time resolution.

公开(公告)号：US20220291191A1

公开(公告)日：2022-09-15

申请号：US17824782

申请日：2022-05-25

Applicant: Agilent Technologies, Inc.

Inventor： Xiaobo Wang ,  Yama A. Abassi ,  Biao Xi ,  Wen Fu Zhang ,  Xiao Xu

IPC: G01N33/483 ,  G01N33/487 ,  G01N33/543 ,  G01N27/02

Abstract: A method for monitoring a cell beating parameter, which includes adding excitable cells capable of beating to a system for monitoring cell-substrate impedance, the system having an electrode array electrically coupled to an impedance analyzer that measures cell-substrate impedance at millisecond time resolution, and a software program that determines a cell beating parameter from measured cell-substrate impedance; monitoring cell-substrate impedance of the excitable cells; and determining the cell beating parameter from the monitored cell-substrate impedance.

公开(公告)号：US11906508B2

公开(公告)日：2024-02-20

申请号：US17993716

申请日：2022-11-23

Applicant: Agilent Technologies, Inc.

Inventor： Xiaobo Wang ,  Yama A. Abassi ,  Biao Xi ,  Wen Fu Zhang ,  Xiao Xu

IPC: G01N33/483 ,  G01N33/487 ,  G01N33/543 ,  G01N27/02

CPC classification number: G01N33/4836 ,  G01N27/02 ,  G01N33/4833 ,  G01N33/48728 ,  G01N33/5438

Abstract: A system for monitoring cells, which includes a device for monitoring cell-substrate impedance, the device having a plurality of wells on a nonconductive substrate, where each of the plurality of wells has an electrode array fabricated on the substrate for measurement of cell-substrate impedance; an impedance analyzer that measures cell-substrate impedance from the plurality of wells; electronic circuitry with multiple analogue-to-digital conversion channels, where the electronic circuitry electrically connects the electrode arrays to the impedance analyzer such that the electrode arrays are electrically monitored at millisecond time resolution; and a software program that analyzes the measured cell-substrate impedance.

公开(公告)号：US20230130050A1

公开(公告)日：2023-04-27

申请号：US17993716

申请日：2022-11-23

Applicant: Agilent Technologies, Inc.

Inventor： Xiaobo Wang ,  Yama A. Abassi ,  Biao Xi ,  Wen Fu Zhang ,  Xiao Xu

IPC: G01N33/483 ,  G01N33/487 ,  G01N33/543 ,  G01N27/02

Abstract: A system for monitoring cells, which includes a device for monitoring cell-substrate impedance, the device having a plurality of wells on a nonconductive substrate, where each of the plurality of wells has an electrode array fabricated on the substrate for measurement of cell-substrate impedance; an impedance analyzer that measures cell-substrate impedance from the plurality of wells; electronic circuitry with multiple analogue-to-digital conversion channels, where the electronic circuitry electrically connects the electrode arrays to the impedance analyzer such that the electrode arrays are electrically monitored at millisecond time resolution; and a software program that analyzes the measured cell-substrate impedance.